Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf
1 PublicationCold denaturation of DNA origami nanostructures
Dornbusch, D.; Hanke, M.; Tomm, E.; Grundmeier, G.; Keller, A.; Fahmy, K.; Kielar, C.
Abstract
The coupling of structural transitions to heat capacity changes leads to destabilization of macromolecules at both, elevated and lowered temperatures. DNA origami not only exhibit this property but also provide a nanoscopic observable of cold denaturation processes by directing intramolecular strain to the most sensitive elements within their hierarchical architecture.
Keywords: protein unfolding; heat capacity; biopolymers; temperature dependence; self assembly; thermal stability
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Chemical Communications 60(2024), 5590-5593
DOI: 10.1039/D3CC05985E
Permalink: https://www.hzdr.de/publications/Publ-37593
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