Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf

This editorial presents three comprehensive reviews of recent preclinical and clinical findings supporting the healing of critical bone defects through adjuvant therapy approaches, which have been published in a special issue. In summary, these articles highlight current concepts that attempt to improve osteogenesis and bone healing using small molecule drugs and intelligent drug delivery methods. The main conclusions lead to an evaluation of the modulation of angiogenesis and microcirculation as a very promising concept. The modulation of inflammation, on the other hand, was evaluated as critical with respect to the start and duration of therapy. Novel solutions are expected from a targeted modulation of bone metabolism, the use of bifunctional or hybrid compounds, appropriate drug combinations and delivery systems.