Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf

2 Publications

Brain volume loss in glioblastoma patients following photon and proton radiochemotherapy

Petr, J.; Hofheinz, F.; Gommlich, A.; Raschke, F.; Troost, E.; Beuthien-Baumann, B.; Seidlitz, A.; Platzek, I.; Baumann, M.; Krause, M.; van den Hoff, J.

Abstract

Gray matter (GM) atrophy in healthy brain tissue following radiochemotherapy was shown in brain-tumor patients in several studies. Here, we aimed to study GM and white matter (WM) changes in glioblastoma patients undergoing photon (n=43) and proton (n=12) radiochemotherapy. In photon-therapy patients, a statistically significant decrease of both GM (~2%) and WM (1.3-2.3%) volume was found with a positive influence of the RT-dose on the GM volume loss. In proton-therapy patients, no significant changes in GM and WM volumes were observed after therapy. This indicates that the proton-therapy has the potential to reduce structural GM changes in healthy tissue.

Keywords: radiochemotherapy; proton therapy; atrophy; morphometrics

Involved research facilities

  • PET-Center
  • Contribution to proceedings
    25th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine, 22.-27.04.2017, Honolulu, Hawaii, USA
    Brain volume loss in glioblastoma patients following photon and proton radiochemotherapy
  • Lecture (Conference)
    25th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine, 22.04.2017, Honolulu, Hawaii

Permalink: https://www.hzdr.de/publications/Publ-25809

Years: 2023 2022 2021 2020 2019 2018 2017 2016 2015