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Thioether ligands as anchor groups for coupling the "Tc(CO)3" moieties with biologically active molecules

Pietzsch, H.-J.; Reisgys, M.; Alberto, R.; Hoepping, A.; Scheunemann, M.; Seifert, S.; Wüst, F.; Spies, H.; Schubiger, P. A.; Johannsen, B.

Abstract

Neutral Re(I) carbonyl complexes with multidentate thioethers of the general formula [ReBr(CO)3(R-S(CH2)2S-R')] were obtained by ligand exchange reaction starting from [ReBr3(CO)3]2-. The thioether ligands bear functional groups (R, R'', such as the carboxyl, propargyl and hydroxyl moiety, which can act as anchor groups for biologically active molecules. First representatives of Re(I) and Tc(I) carbonyl thioether complexes, meant to target CNS neuroreceptors and hormone receptor-positive breast tumors, are described.

  • Book (Authorship)
    Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine (Edited by Nicolini M., Mazzi U.) SGE Editoriali Padova (1999), pp. 313-316

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