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1 PublicationFunctional arterial spin labeling: Optimal sequence duration for motor activation mapping in clinical practice
Raoult, H.; Ferré, J.-C.; Petr, J.; Bannier, E.; Stamm, A.; Barillot, C.; Gauvrit, J.-Y.
Abstract
Purpose: To determine the minimal optimal fASL sequence duration allowing steady and reproducible motor activation mapping.
Materials and methods: Three MRI sessions including fASL and BOLD fMRI sequences were performed on 12 healthy subjects at 3T with a 32-channel coil. The raw 7 min fASL sequence was truncated to obtain six fASL sequences with durations ranging from 1 to 6 min. All the resulting fASL activations were compared between themselves and with both the 7 min fASL and BOLD activations. Quantitative parameters assessed activation location (activated volume, barycenter and distance between barycenters), activation quantification (activation-related cerebral blood flow), and intra-individual reproducibility across fMRI sessions.
The statistical analysis was based on ANOVA and Tukey’s multiple comparisons.
Results: Four min fASL achieved steady location and quantification of activation with the activated volume corresponding to 81% of the 7 min fASL volume and a barycenter located 1.2 mm from the 7 min fASL barycenter and 3.0 mm from the BOLD fMRI barycenter. Four min fASL reproducibility was high and statistically equivalent to 7 min values.
Conclusion: A 4 min fASL sequence is thus a reliable tool for motor activation mapping and suitable for use in clinical practice.
Involved research facilities
- PET-Center
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Journal of Magnetic Resonance Imaging 36(2012), 1435-1444
DOI: 10.1002/jmri.23782
Cited 3 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-17857
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