Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf

An increasing demand of radiopharmaceuticals based on electrophilic reaction with [¹⁸F]F₂ gas (for instance [¹⁸F]FDOPA) led to an upgrade of the IBA [¹⁸F]F₂ gas target system in summer 2007. The more than 10 years operated [¹⁸F]F₂ deuteron target [²⁰Ne(p,α)¹⁸F] was not able to meet the increasing requirements in terms of activity anymore and was thus replaced by an IBA [¹⁸F]F₂ proton gas target [¹⁸O(p,n)¹⁸F] based on the so-called “double-shot” ‘irradiation method by R.J. Nickles [1]. The upgrade itself was done by IBA.
We run the Cyclone® 18/9 cyclotron in routine operation for more than 14 years. One of the specific features of the Rossendorf PET Center is the Radionuclide transport system (RATS) [2], 500 m in length that bridges the distance from the cyclotron to the radiopharmaceutical laboratories. The activity at the end of bombardment (EOB) is calculated taking in account the transfer time and experimental data of activity losses (about 30%) in the transfer tube [2].