Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf
1 PublicationInvestigation into the metabolic stability of 18F-labeled PSMA inhibitor derivatives bearing aryl-fluorosulfates for PET tracer development applications
Luque Consuegra, G.; Craig, A.; Kogler, J.; Ullrich, M.; Donat, C.; Kopka, K.; Stadlbauer, S.
Abstract
This poster highlights the use of the sulfur [18F]fluoride exchange approach to radiolabel a PSMA inhibitor ([18F]2) and test its radiolabeling, in vitro and in vivo properties.
- [18F]2 shows good binding kinetics compared to known radiotracers (1 nM) but ~20%
- [18F]2 binds to LNCaP xenograft sections in a similar pattern as [68Ga]Ga-PSMA-11.
- PET imaging experiments show defluorination but also accumulation in LNCaP tumor
- Further work: Radiosynthesis of [18F]4 starting from precursor 3 (in poster)
Keywords: sulfur [18F]fluoride exchange approach; Radiolabeling; PET; PSMA; Radiopharmaceuticals
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Poster
21st European Symposium on Radiopharmacy & Radiopharmaceuticals, 18.-21.04.2024, Coimbra, Portugal
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Permalink: https://www.hzdr.de/publications/Publ-39001
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