Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf
3 PublicationsCerebrovascular Brain-age
Dijsselhof, M. B. J.; Barboure, M.; Stritt, M.; Nordhøy, W.; Wink, A. M.; Westlye, L. T.; Cole, J. H.; Barkhof, F.; Petr, J.; Mutsaerts, H. J. M. M.
Abstract
Brain-age estimates the biological brain age from structural MRI images based on changes in brain-tissue integrity and irreversible
structural changes [1]. The brain-age offset to the chronological age — the age gap — is associated with cognitive pathology [2]. Adding
vascular or functional MRI biomarkers may add sensitivity to physiological and metabolic changes, complementing and improving structural
brain-age, and possibly improving its sensitivity to earlier disease changes. Arterial spin labeling (ASL) MRI is a potential early biomarker of
cerebrovascular health and correlates with the initial stages of cognitive pathology [3]. Here, we propose the ‘Cerebrovascular Brain-age’ as a
combination of T1w, FLAIR, and ASL image features composed of the spatial Coefficient of Variation (CoV) and vascular-territory derived
(VT) cerebral blood flow (CBF).
Involved research facilities
- PET-Center
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Poster
ISMRM '22 Workshop on Perfusion MRI: From Head to Toe, 04.-07.03.2022, Los Angeles, USA -
Contribution to proceedings
ISMRM '22: 30th Annual Meeting & Exhibition, 07.-12.05.2022, London, United Kingdom
Proceedings of the ISMRM 30th Annual Meeting & Exhibition -
Poster
ISMRM '22: 30th Annual Meeting & Exhibition, 07.-12.05.2022, London, United Kingdom
Permalink: https://www.hzdr.de/publications/Publ-34732
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