Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf

2 Publications

Evaluation of hemodynamic impairments in healthy elderly participants and patients with high-grade unilateral carotid artery stenosis

Kaczmarz, S.; Göttler, J.; Griese, V.; Petr, J.; van de Ven, K.; Helle, M.; Kooijman, H.; Kluge, A.; Karampinos, D.; Zimmer, C.; Sorg, C.; Preibisch, C.

Abstract

Internal carotid-artery stenosis (ICAS) causes complex and not yet well understood physiological impairments. We present preliminary data from an ongoing clinical study in ICAS patients and healthy, age-matched participants. The major aims were to evaluate the reliability of a multimodal MRI-protocol and investigate physiological changes. For ICAS patients, regionally impaired vascular-reactivity as well as hypo-perfusion were found. In accordance with literature, we did not find ICAS-induced changes in oxygen extraction on group level. The presented preliminary results thus imply successful application of multimodal MRI methods and are highly promising with respect to gaining a deeper insight into ICAS-related physiological changes.

Keywords: stenosis; ASL; perfusion; MRI

Involved research facilities

  • PET-Center
  • Contribution to proceedings
    25th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine, 22.-27.04.2017, Honolulu, Hawaii, USA
    Proceedings of the 25th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine
  • Lecture (Conference)
    25th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine, 22.04.2017, Honolulu, Hawaii, USA

Permalink: https://www.hzdr.de/publications/Publ-25811

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