Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf

S100A12 is a member of the S100 family of EF-hand calcium-binding proteins. Human S100A12 is predominantly expressed and secreted by neutrophil granulocytes and, therefore, has been assigned to the S100 protein subfamily of calgranulins. It is part of the innate immune response and linked to certain autoimmune reactions. Human S100A12 is markedly overexpressed in inflammatory compartments, and elevated serum levels of S100A12 are found in patients suffering from metabolic, neurodegenerative, inflammatory and neoplastic disorders. In this regard, interaction of calcium-activated S100A12 with the receptor for advanced glycation endproducts (RAGE) plays a central pathogenetic role.