Publications of Institute of Radiopharmaceutical Cancer Research - Year 2018
50 Publications2018
Pretherapeutic FDG–PET total metabolic tumor volume predicts response to induction therapy in pediatric Hodgkin’s lymphoma
Rogasch, J.; Hundsdoerfer, P.; Hofheinz, F.; Wedel, F.; Schatka, I.; et al. (7 authors)
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BMC Cancer 18(2018), 521
DOI: 10.1186/s12885-018-4432-4
Evaluation of Brain Nuclear Medicine Imaging Tracers in a Murine Model of Sepsis-Associated Encephalopathy
Szöllősi, D.; Hegedűs, N.; Veres, D. S.; Futó, I.; Horváth, I.; et al. (15 authors)
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Molecular Imaging and Biology 20(2018), 952-962
DOI: 10.1007/s11307-018-1201-3
Immune Monitoring of Cancer Patients Prior to and During CTLA-4 or PD-1/PD-L1 Inhibitor Treatment
Tunger, A.; Kießler, M.; Wehner, R.; Temme, A.; Meier, F.; et al. (7 authors)
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Biomedicines 6(2018)1, 26
DOI: 10.3390/biomedicines6010026
Multimodal PET/MRI Imaging Results Enable Monitoring the Side Effects of Radiation Therapy.
Kovács, N.; Szigeti, K.; Hegedűs, N.; Horváth, I.; Veres, D. S.; et al. (8 authors)
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Contrast Media & Molecular Imaging (2018), 5906471
DOI: 10.1155/2018/5906471
In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by 18F-FDG PET/CT
Verloh, N.; Einspieler, I.; Utpatel, K.; Menhart, K.; Brunner, S.; et al. (12 authors)
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EJNMMI Research 8(2018), 98
DOI: 10.1186/s13550-018-0452-y
Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety
Bergkemper, M.; Kronenberg, E.; Thum, S.; Börgel, F.; Daniliuc, C.; et al. (11 authors)
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Journal of Medicinal Chemistry 61(2018), 9666-9690
DOI: 10.1021/acs.jmedchem.8b01183
Diverse Effects of Phospholipase A2 Receptor Expression on LNCaP and PC-3 Prostate Cancer Cell Growth in vitro and in vivo
Friedemann, M.; Nacke, B.; Hagelgans, A.; Jandeck, C.; Bechmann, N.; et al. (11 authors)
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Oncotarget 9(2018), 35983-35996
DOI: 10.18632/oncotarget.26316
Towards Utilising Photocrosslinking of Polydiacetylenes for the Preparation of “Stealth” Upconverting Nanoparticles
Nsubuga, A.; Zarschler, K.; Sgarzi, M.; Graham, B.; Stephan, H.; et al. (6 authors)
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Angewandte Chemie - International Edition 57(2018), 16036
DOI: 10.1002/anie.201811003
Improved Conjugation, 64-Cu Radiolabeling, in Vivo Stability, and Imaging Using Nonprotected Bifunctional Macrocyclic Ligands: Bis(Phosphinate) Cyclam (BPC) Chelators
David, T.; Hlinová, V.; Kubíček, V.; Bergmann, R.; Striese, F.; et al. (12 authors)
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Journal of Medicinal Chemistry 61(2018), 8774-8796
DOI: 10.1021/acs.jmedchem.8b00932
Fourier Analysis of Cerebral Metabolism of Glucose: Gender Differences in Mechanisms of Color Processing in the Ventral and Dorsal Streams in Mice
Njemanze, P. C.; Kranz, M.; Brust, P.
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Forecasting 1(2018), 135-156
DOI: 10.3390/forecast1010010
ISSN: 2571-9394
NMR-based investigations of acyl-functionalized piperazines concerning their conformational behavior in solution
Steinberg, J.; Köckerling, M.; Wodtke, R.; Löser, R.; Mamat, C.
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RSC Advances 8(2018), 40921-40933
DOI: 10.1039/C8RA09152H
Synthesis, characterization and initial biological evaluation of [⁹⁹ᵐTc]Tc-tricarbonyl labeled DPA-α-MSH peptide derivatives for potential melanoma imaging
Gao, F.; Sihver, W.; Bergmann, R.; Belter, B.; Bolzati, C.; et al. (9 authors)
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ChemMedChem 13(2018)11, 1146-1158
DOI: 10.1002/cmdc.201800110
Exploring pitfalls of 64Cu‑labeled EGFR‑targeting peptide GE11 as a potential PET tracer
Striese, F.; Sihver, W.; Gao, F.; Bergmann, R.; Walther, M.; et al. (8 authors)
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Amino Acids 50(2018)10, 1415-1431
DOI: 10.1007/s00726-018-2616-5
Development of a novel target module redirecting UniCAR T cells to Sialyl Tn-expressing tumor cells
Loureiro, L.; Feldmann, A.; Bergmann, R.; Koristka, S.; Berndt, N.; et al. (10 authors)
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Blood Cancer Journal 8(2018), 81
DOI: 10.1038/s41408-018-0113-4
Strain-specific metastatic phenotypes in pheochromocytoma allograft mice
Ullrich, M.; Liers, J.; Peitzsch, M.; Feldmann, A.; Bergmann, R.; et al. (12 authors)
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Endocrine-Related Cancer 25(2018)12, 993-1004
DOI: 10.1530/ERC-18-0136
Development of a selective and highly sensitive fluorescence assay for nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39)
Lee, S.-Y.; Luo, X.; Namasivayam, V.; Geiss, J.; Mirza, S.; et al. (9 authors)
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Analyst 143(2018), 5417-5430
DOI: 10.1039/c8an01108g
Cerebrovascular Reactivity during Prolonged Breath-Hold in Experienced Freedivers
Keil, V.; Eichhorn, L.; Mutsaerts, H.; Träber, F.; Block, W.; et al. (13 authors)
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American Journal of Neuroradiology 39(2018)10, 1839-1847
DOI: 10.3174/ajnr.A5790
Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition and H3R Antagonism with Sigma 1R Agonism Profile
Bautista-Aguilera, O. M.; Budni, J.; Mina, F.; Medeiros, E. B.; Deuther-Conrad, W.; et al. (10 authors)
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Journal of Medicinal Chemistry 61(2018), 6937-6943
DOI: 10.1021/acs.jmedchem.8b00848
From mono- to bivalent: improving theranostic properties of target modules for redirection of UniCAR T cells against EGFR-expressing tumor cells in vitro and in vivo
Albert, S.; Arndt, C.; Koristka, S.; Berndt, N.; Bergmann, R.; et al. (10 authors)
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Oncotarget 9(2018)39, 25597-25616
DOI: 10.18632/oncotarget.25390
Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer's dementia
Sabri, O.; Meyer, P. M.; Gräf, S.; Hesse, S.; Wilke, S.; et al. (21 authors)
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Brain 141(2018)6, 1840-1854
DOI: 10.1093/brain/awy099
Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor
Lindemann, M.; Hinz, S.; Deuther-Conrad, W.; Namasivayam, V.; Dukic-Stefanovic, S.; et al. (13 authors)
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Bioorganic & Medicinal Chemistry 26(2018), 4650-4663
DOI: 10.1016/j.bmc.2018.07.045
Monitoring scanner calibration using the image derived arterial blood SUV in whole-body FDG-PET
Maus, J.; Hofheinz, F.; Apostolova, I.; Kreissl, M. C.; Kotzerke, J.; et al. (6 authors)
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EJNMMI Research 8(2018)38
DOI: 10.1186/s13550-018-0391-7
Increased evidence for the prognostic value of late-treatment FDG-PET uptake in non-tumor affected oesophagus in irradiated patients with oesophageal carcinomas
Li, Y.; Hofheinz, F.; Furth, C.; Lili, C.; Hua, W.; et al. (7 authors)
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European Journal of Nuclear Medicine and Molecular Imaging 45(2018)10, 1752-1761
DOI: 10.1007/s00259-018-3996-1
Effects of systematic partial volume errors on the computation of mean gray matter cerebral blood flow with Arterial Spin Labeling MRI
Petr, J.; Mutsaerts, H. J. M. M.; de Vita, E.; Steketee, R. M. E.; Smits, M.; et al. (9 authors)
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Magnetic Resonance Materials in Physics, Biology and Medicine 31(2018)6, 725-734
DOI: 10.1007/s10334-018-0691-y
Preyssler-Pope-Jeannin Polyanions [NaP5W30O110]14- and [AgP5W30O110]14-: Synthesis, Structural Characterization, Electrochemistry, Antiproliferative and Antibacterial Activity
Haider, A.; Zarschler, K.; Joshi, S. A.; Smith, R.; Lin, Z.; et al. (10 authors)
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Zeitschrift für Anorganische und Allgemeine Chemie 644(2018), 752-758
DOI: 10.1002/zaac.201800113
Synthesis and radiofluorination of novel fluoren-9-one based derivatives for the imaging of α7 nicotinic acetylcholine receptor with PET
Teodoro, R.; Scheunemann, M.; Wenzel, B.; Peters, D.; Deuther-Conrad, W.; et al. (6 authors)
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Bioorganic & Medicinal Chemistry Letters 28(2018), 1471-1475
DOI: 10.1016/j.bmcl.2018.03.081
Molekulare Bildgebung in der Onkologie mittels Positronen-Emissions-Tomographie
Derlin, T.; Grünwald, V.; Steinbach, J.; Wester, H.-J.; Ross, T. L.
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Deutsches Ärzteblatt International 115(2018)11, 175-181
DOI: 10.3238/arztebl.2018.0175
Harnessing the Coordination Chemistry of 1,4,7-Triazacyclononane for Biomimicry and Radiopharmaceutical Applications
Joshi, T.; Kubeil, M.; Nsubuga, A.; Singh, G.; Gasser, G.; et al. (6 authors)
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ChemPlusChem 83(2018), 554-564
DOI: 10.1002/cplu.201800103
Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies-the German Cancer Consortium approach.
Krackhardt, A. M.; Anliker, B.; Hildebrandt, M.; Bachmann, M.; Eichmüller, S. B.; et al. (12 authors)
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Cancer Immunology, Immunotherapy 67(2018)4, 513-523
DOI: 10.1007/s00262-018-2119-y
Nε-Acryloyllysine piperazides as irreversible inhibitors of transglutaminase 2 – synthesis, structure-activity relationships and pharmacokinetic profiling
Wodtke, R.; Hauser, C.; Ruiz-Gómez, G.; Jäckel, E.; Bauer, D.; et al. (16 authors)
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Journal of Medicinal Chemistry 61(2018)10, 4528-4560
DOI: 10.1021/acs.jmedchem.8b00286
Biodistribution studies of ultrasmall silicon nanoparticles and carbon dots in experimental rats and tumor mice
Licciardello, N.; Hunoldt, S.; Bergmann, R.; Singh, G.; Mamat, C.; et al. (11 authors)
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Nanoscale 10(2018), 9880-9891
DOI: 10.1039/C8NR01063C
Overexpression of receptor tyrosine kinase EphB4 triggers tumor growth and hypoxia in A375 melanoma xenografts: insights from multitracer small animal imaging experiments
Neuber, C.; Belter, B.; Meister, S.; Hofheinz, F.; Bergmann, R.; et al. (7 authors)
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Molecules 23(2018), 444
DOI: 10.3390/molecules23020444
Modified Calix[4]crowns as Molecular Receptors for Barium
Steinberg, J.; Bauer, D.; Reissig, F.; Köckerling, M.; Pietzsch, H.-J.; et al. (6 authors)
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ChemistryOpen 7(2018)6, 432-438
DOI: 10.1002/open.201800019
Exploring the Metabolism of (+)-[18F]Flubatine in vitro and in vivo: LC-MS/MS aided Identification of Radiometabolites in a Clinical PET Study
Ludwig, F.-A.; Fischer, S.; Smits, R.; Deuther-Conrad, W.; Hoepping, A.; et al. (9 authors)
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Molecules 23(2018)1, 464
DOI: 10.3390/molecules23020464
Facile Preparation of Multifunctionalisable ‘Stealth’ Upconverting Nanoparticles for Biomedical Applications
Nsubuga, A.; Sgarzi, M.; Zarschler, K.; Kubeil, M.; Hübner, R.; et al. (9 authors)
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Dalton Transactions 47(2018), 8595-8604
DOI: 10.1039/C8DT00241J
Investigation of an 18F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A
Schröder, S.; Wenzel, B.; Deuther-Conrad, W.; Teodoro, R.; Kranz, M.; et al. (11 authors)
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Molecules 23(2018)3, 556
DOI: 10.3390/molecules23030556
Bridging from Brain to Tumor imaging: (S)- and (R)-[18F]Fluspidine for investigation of Sigma-1 Receptors in Tumor-bearing Mice
Kranz, M.; Bergmann, R.; Kniess, T.; Belter, B.; Neuber, C.; et al. (14 authors)
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Molecules 23(2018)3, 702
DOI: 10.3390/molecules23030702
Spectroscopic Studies on Photoinduced Reactions of the Anticancer Prodrug, trans,trans,trans-[Pt(N3)2(OH)2(py)2]
Vernooij, R. R.; Joshi, T.; Horbury, M. D.; Graham, B.; Izgorodina, E. I.; et al. (9 authors)
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Chemistry - A European Journal 24(2018)22, 5790-5803
DOI: 10.1002/chem.201705349
Causative treatment of acid aspiration induced acute lung injury – recent trends from animal experiments and critical perspective
Gramatté, J.; Pietzsch, J.; Bergmann, R.; Richter, T.
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Clinical Hemorheology and Microcirculation 69(2018), 187-195
DOI: 10.3233/CH-189113
ISSN: 1386-0291
Engrafting human regulatory T cells with a flexible modular chimeric antigen receptor technology
Koristka, S.; Kegler, A.; Bergmann, R.; Arndt, C.; Feldmann, A.; et al. (17 authors)
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Journal of Autoimmunity 90(2018), 116-131
DOI: 10.1016/j.jaut.2018.02.006
Rapid synthesis of sub-10 nm hexagonal NaYF4-based upconverting nanoparticles using Therminol 66
Hesse, J.; Klier, D. T.; Sgarzi, M.; Nsubuga, A.; Bauer, C.; et al. (11 authors)
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ChemistryOpen 7(2018)2, 159-168
DOI: 10.1002/open.201700186
Photon vs. proton radiochemotherapy: effects on brain tissue volume and perfusion
Petr, J.; Platzek, I.; Hofheinz, F.; Mutsaerts, H.; Asllani, I.; et al. (16 authors)
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Radiotherapy and Oncology 128(2018), 121-127
DOI: 10.1016/j.radonc.2017.11.033
Chelation of heavy group 2 (radio)metals by p-tert-butylcalix[4]arene-1,3-crown-6 and logK determination via NMR
Bauer, D.; Gott, M.; Steinbach, J.; Mamat, C.
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Spectrochimica Acta Part A 199(2018), 50-56
DOI: 10.1016/j.saa.2018.03.029
Evaluation of fluorine-18-labelled alpha1(I)-N-telopeptide analogues as substrate-based radiotracers for PET imaging of melanoma-associated lysyl oxidase
Kuchar, M.; Neuber, C.; Belter, B.; Bergmann, R.; Lenk, J.; et al. (10 authors)
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Frontiers in Chemistry 6(2018), 121
DOI: 10.3389/fchem.2018.00121
Facile Silylation of Cyclitols using Silyl-bis(triflates)
Topp, A.; Köckerling, M.; Reinke, H.; Miethchen, R.; Mamat, C.
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European Journal of Inorganic Chemistry (2018), 1302-1308
DOI: 10.1002/ejic.201701327
Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI)
Mutsaerts, H. J. M. M.; Petr, J.; Thomas, D. L.; de Vita, E.; Cash, D. M.; et al. (23 authors)
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Journal of Magnetic Resonance Imaging 47(2018)1, 131-140
Online First (2017) DOI: 10.1002/jmri.25751
A Bayesian Approach for Measurements of Stray Neutrons at Proton Therapy Facilities: Quantifying Neutron Dose Uncertainty
Dommert, M.; Reginatto, M.; Zboril, M.; Fiedler, F.; Helmbrecht, S.; et al. (7 authors)
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Radiation Protection Dosimetry 180(2018)1-4, 319-323
Online First (2017) DOI: 10.1093/rpd/ncx264
Recent Progress using the Staudinger Ligation for Radiolabeling Applications
Mamat, C.; Gott, M.; Steinbach, J.
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Journal of Labelled Compounds and Radiopharmaceuticals 61(2018), 165-178
DOI: 10.1002/jlcr.3562
Novel Valdecoxib Derivates by Ruthenium-catalyzed 1,3-Dipolar Cycloaddition of Nitrile Oxides with Alkynes - Synthesis and COX-2 Inhibition Affinity.
Roscales, S.; Bechmann, N.; Weiss, D. H.; Köckerling, M.; Pietzsch, J.; et al. (6 authors)
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MedChemComm 9(2018), 534-544
DOI: 10.1039/c7md00575j
Structural and kinetic considerations for the application of the traceless Staudinger ligation to future 18F radiolabeling using XRD and 19F-NMR
Köckerling, M.; Mamat, C.
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International Journal of Chemical Kinetics 50(2018), 31-40
DOI: 10.1002/kin.21137
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