Publications of Institute of Radiopharmaceutical Cancer Research - Year 2012
43 Publications2012
Cerebral blood flow quantification in the rat: a direct comparison of arterial spin labeling MRI with radioactive microsphere PET
Bos, A.; Bergmann, R.; Strobel, K.; Hofheinz, F.; Steinbach, J.; et al. (6 authors)
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EJNMMI Research 2(2012)47
DOI: 10.1186/2191-219X-2-47
ISSN: 2191-219X
Feasibility of estimation of brain volume and 2-deoxy-2-F-18-fluoro-D-glucose metabolism using a novel automated image analysis method: Application in Alzheimer's disease
Musiek, E. S.; Saboury, B.; Mishra, S.; Chen, Y.; Reddin, J. S.; et al. (11 authors)
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Hellenic Journal of Nuclear Medicine 15(2012), 190-196
ISSN: 1790-5427
Exploratory prospective trial of hypoxia-specific PET imaging during radiochemotherapy in patients with locally advanced head-and-neck cancer
Zips, D.; Zöphel, K.; Abolmaali, N.; Perrin, R.; Abramyuk, A.; et al. (10 authors)
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Radiotherapy and Oncology 105(2012), 21-28
DOI: 10.1016/j.radonc.2012.08.019
Flow cytometric cell-based assay to preselect antibody constructs for radionuclide conjugation
Ingargiola, M.; Dittfeld, C.; Runge, R.; Zenker, M.; Heldt, J.-M.; et al. (10 authors)
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Cytometry Part A 81A(2012), 865-873
DOI: 10.1002/cyto.a.22110
Synthesis and biological evaluation of a novel Tc-99m cyclopentadienyl tricarbonyl complex ([(Cp-R)Tc-99m(CO)(3)]) for sigma-2 receptor tumor imaging
Chen, X.; Cui, M. C.; Deuther-Conrad, W.; Tu, Y. F.; Ma, T.; et al. (14 authors)
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Bioorganic & Medicinal Chemistry Letters 22(2012)20, 6352-6357
DOI: 10.1016/j.bmcl.2012.08.083
ISSN: 0960-894X
Protein and non-protein biomarkers in melanoma: a critical update.
Tandler, N.; Mosch, B.; Pietzsch, J.
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Amino Acids 6(2012), 2203-2230
DOI: 10.1007/s00726-012-1409-5
Functional arterial spin labeling: Optimal sequence duration for motor activation mapping in clinical practice
Raoult, H.; Ferré, J.-C.; Petr, J.; Bannier, E.; Stamm, A.; et al. (7 authors)
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Journal of Magnetic Resonance Imaging 36(2012), 1435-1444
DOI: 10.1002/jmri.23782
Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2
Caballero, J.; Muñoz, C.; Alzate-Morales, J. H.; Cunha, S.; Gano, L.; et al. (8 authors)
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European Journal of Medicinal Chemistry 58(2012), 272-280
DOI: 10.1016/j.ejmech.2012.10.020
Cellular and molecular properties of 90Y-labeled cetuximab in combination with radiotherapy on human tumor cells in vitro
Saki, M.; Toulany, M.; Sihver, W.; Zenker, M.; Heldt, J.-M.; et al. (10 authors)
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Strahlentherapie und Onkologie 9(2012), 823-832
DOI: 10.1007/s00066-012-0121-4
18F-Labeled phosphopeptide-cell-penetrating peptide dimers with enhanced cell uptake properties in human cancer cells
Richter, S.; Bouvet, V.; Wuest, M.; Bergmann, R.; Steinbach, J.; et al. (8 authors)
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Nuclear Medicine and Biology 39(2012)8, 1202-1212
DOI: 10.1016/j.nucmedbio.2012.06.003
Synthesis and cytotoxicity of pyridine and quinoline oxorhenium(V) complexes with tridentate (NS2, S-3)/monodentate (s) coordination
Segal, I.; Zablotskaya, A.; Kniess, T.; Shestakova, I.
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Chemistry of Heterocyclic Compounds 48(2012), 296-300
DOI: 10.1007/s10593-012-0989-z
ISSN: 0009-3122
18F-labelled CCR1-receptor antagonist is not suitable for imaging of Alzheimer's disease
Beuthien-Baumann, B.; Holthoff, V.; Mäding, P.; Bergmann, R.; Pawelke, B.; et al. (9 authors)
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Nuklearmedizin 51(2012), 239-243
DOI: 10.3413/Nukmed-0457-12-01
ISSN: 0029-5566
Cannabinoid Receptor Type 2 (CB2) Selective N-Aryl-oxadiazolyl-propionamides: Synthesis, Radiolabeling, Molekular Modelling and Biological Evaluation
Rühl, T.; Deuther-Conrad, W.; Fischer, S.; Günther, R.; Hennig, L.; et al. (7 authors)
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Organic and Medicinal Chemistry Letters 2(2012), 32
DOI: 10.1186/2191-2858-2-32
Synthesis and crystal structure of benzyl[(1S)-1-(5-amino-1,3,4-oxadiazol-2-yl)-2-phenylethyl]carbamate
Löser, R.; Nieger, M.; Gütschow, M.
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Crystals 2(2012), 1201-1209
DOI: 10.3390/cryst2031201
ISSN: 2073-4352
Combined PET/MR systems: an overview and comparison of currently available options
Herzog, H.; van den Hoff, J.
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Quarterly Journal of Nuclear Medicine and Molecular Imaging 56(2012), 247-267
ISSN: 1824-4785
Improved anatomic visualization of a glomus caroticum tumour within the carotic bifurcation with combined 68Ga-DOTATATE PET/MRI
Beuthien-Baumann, B.; Platzek, I.; Lauterbach, I.; van den Hoff, J.; Schramm, G.; et al. (8 authors)
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European Journal of Nuclear Medicine and Molecular Imaging 39(2012), 1087-1088
DOI: 10.1007/s00259-012-2097-9
Fluorine-18-Radiolabeling and Radiopharmacological Characterization of a Benzodioxolylpyrimidine as a Radiotracer Targeting the Receptor Tyrosine Kinase EphB4
Mamat, C.; Mosch, B.; Neuber, C.; Köckerling, M.; Bergmann, R.; et al. (6 authors)
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ChemMedChem 7(2012)11, 1991-2003
DOI: 10.1002/cmdc.201200264
Novel 7α-alkoxy-17α-(4’-halophenylethynyl)estradiols as potential SPECT/PET imaging agents for estrogen receptor expressing tumors: synthesis and binding affinity evaluation
Neto, C.; Oliveira, M. C.; Gano Fernanda Marques, M. L.; Yasuda, T.; Thiemann, T.; et al. (7 authors)
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Steroids 77(2012), 1123-1132
DOI: 10.1016/j.steroids.2012.05.004
Synthesis and characterization of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X = O, S)
Peruzzo, V.; Pretzsch, C.; Tisato, F.; Porchia, M.; Refosco, F.; et al. (10 authors)
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Inorganica Chimica Acta 387(2012), 163-172
DOI: 10.1016/j.ica.2012.01.012
Synthesis, in vitro and in vivo characterization of novel 99mTc-‘4+1’-labeled 5-nitroimidazole derivatives as potential agents for imaging hypoxia
Giglio, J.; Fernández, S.; Pietzsch, H.-J. D.; Dematteis, S.; Moreno, M.; et al. (8 authors)
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Nuclear Medicine and Biology 39(2012), 679-686
DOI: 10.1016/j.nucmedbio.2011.12.012
Design, Evaluation, and Comparison of Ghrelin Receptor Agonists and Inverse Agonists as Suitable Radiotracers for PET Imaging
Chollet, C.; Bergmann, R.; Pietzsch, J.; Beck-Sickinger, A. G.
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Bioconjugate Chemistry 23(2012), 771-784
DOI: 10.1021/bc2005889
Irradiation affects cellular properties and Eph receptor expression in human melanoma cells
Mosch, B.; Pietzsch, D.; Pietzsch, J.
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Cell Adhesion & Migration 6(2012)2, 113-125
DOI: 10.4161/cam.20655
ISSN: 1933-6918
A method for model-free partial volume correction in oncological PET
Hofheinz, F.; Langner, J.; Petr, J.; Beuthien-Baumann, B.; Oehme, L.; et al. (8 authors)
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EJNMMI Research 2(2012)16
DOI: 10.1186/2191-219X-2-16
ISSN: 2191-219X
Radioiodinated sunitinib as a potential radiotracer for imaging angiogenesis - radiosynthesis and first radiopharmacological evaluation of 5-[125I]Iodo-sunitinib
Kuchar, M.; Oliveira, M. C.; Gano, L.; Santos, I.; Knieß, T.
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Bioorganic & Medicinal Chemistry Letters 22(2012), 2850-2855
DOI: 10.1016/j.bmcl.2012.02.068
Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents
Neto, C.; Fernandes, C.; Oliveira, M. C.; Gano, L.; Mendes, F.; et al. (7 authors)
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Nuclear Medicine and Biology 39(2012), 247-260
DOI: 10.1016/j.nucmedbio.2011.09.001
Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum
Melani, A.; Corti, F.; Stephan, H.; Müller, C. E.; Donati, C.; et al. (8 authors)
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Experimental Neurology 233(2012), 193-204
DOI: 10.1016/j.expneurol.2011.09.036
Study of differences in the VEGFR2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations
Munoza, C.; Adasmea, F.; Alzate-Morales, J. H.; Vergara-Jaquea, A.; Kniess, T.; et al. (6 authors)
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Journal of Molecular Graphics and Modelling 32(2012), 39-48
DOI: 10.1016/j.jmgm.2011.10.005
Radiolabeled small molecule inhibitors of VEGFR – recent advances
Kniess, T.
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Current Pharmaceutical Design 18(2012), 2867-2874
DOI: 10.2174/138161212800672796
ISSN: 1873-4286
Module-assisted preparation of 64Cu with high specific activity
Thieme, S.; Walther, M.; Pietzsch, H.-J.; Henniger, J.; Preusche, S.; et al. (7 authors)
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Applied Radiation and Isotopes 70(2012), 602-608
DOI: 10.1016/j.apradiso.2012.01.019
SUV-measurements and patient-specific corrections thereof in pediatric Hodgkin-lymphoma: Is there a benefit for PPV in early response assessment by FDG-PET?
Furth, C.; Meseck, R. M.; Steffen, I. G.; Schoenberger, S.; Denecke, T.; et al. (12 authors)
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Pediatric Blood & Cancer 59(2012), 475-480
DOI: 10.1002/pbc.24047
Automatic volume delineation in oncological PET. Evaluation of a dedicated software tool and comparison with manual delineation in clinical data sets
Hofheinz, F.; Pötzsch, C.; Oehme, L.; Beuthien-Baumann, B.; Steinbach, J.; et al. (7 authors)
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Nuklearmedizin 51(2012), 9-16
DOI: 10.3413/Nukmed-0419-11-07
ISSN: 0029-5566
Synthesis and Molecular Structure of tert-Butyl 4-(2-tert-butoxy-2-oxoethyl)piperazine-1-carboxylate
Mamat, C.; Flemming, A.; Köckerling, M.
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Crystals 2(2012), 90-95
DOI: 10.3390/cryst2010090
ISSN: 2073-4352
The Synthesis and Molecular Structure of 2-(4-Methoxybenzyl)-4-nitro-2H-indazole
Ebert, K.; Köckerling, M.; Mamat, C.
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Crystals 2(2012), 176-181
DOI: 10.3390/cryst2020176
Specific targeting of hypoxic tumor tissue with nitroimidazole-peptide conjugates
Splith, K.; Bergmann, R.; Pietzsch, J.; Neundorf, I.
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ChemMedChem 7(2012), 57-61
DOI: 10.1002/cmdc.201100401
Pyrrolovesamicols - Synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers
Wenzel, B.; Li, Y.; Kraus, W.; Sorger, D.; Sabri, O.; et al. (7 authors)
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Bioorganic & Medicinal Chemistry Letters 22(2012), 2163-2166
DOI: 10.1016/j.bmcl.2012.01.127
The Molecular Structure of 1,2:5,6-Di-O-isopropylidene-3-O-toluenesulfonyl-a-D-glucofuranose
Mamat, C.; Peppel, T.; Köckerling, M.
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Crystals 2(2012), 105-109
DOI: 10.3390/cryst2010105
ISSN: 2073-4352
Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans
Hesse, S.; Brust, P.; Mäding, P.; Becker, G.-A.; Seese, A.; et al. (17 authors)
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European Journal of Nuclear Medicine and Molecular Imaging 39(2012)6, 1001-1011
DOI: 10.1007/s00259-012-2078-z
Development of radioligands for α7-nAChR imaging with positron emission tomography
Brust, P.; Peters, D.; Deuther-Conrad, W.
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Current Drug Targets 13(2012)5, 594-601
DOI: 10.2174/138945012800398955
ISSN: 1389-4501
Synthesis, radiofluorination and pharmacological evaluation of fluoromethyl substituted spirocyclic PET tracers for labeling of σ1 receptors in the central nervous system and comparison with longer homologues
Maisonial, A.; Grosse Maestrup, E.; Wiese, C.; Hiller, A.; Schepmann, D.; et al. (9 authors)
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Bioorganic & Medicinal Chemistry 20(2012), 257-269
DOI: 10.1016/j.bmc.2011.11.002
Radiosynthesis and Radiotracer Properties of a 7-(2-[F-18]Fluoroethoxy)-6-methoxy-pyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET
Funke, U.; Deuther-Conrad, W.; Schwan, G.; Maisonial, A.; Scheunemann, M.; et al. (9 authors)
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Pharmaceuticals 5(2012)2, 169-188
DOI: 10.3390/ph5020169
ISSN: 1424-8247
Site-selective radiolabeling of peptides by 18F-fluorobenzoylation with [18F]SFB in solution and on solid phase - a comparative study
Kuchar, M.; Pretze, M.; Knieß, T.; Steinbach, J.; Pietzsch, J.; et al. (6 authors)
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Amino Acids 43(2012), 1431-1443
DOI: 10.1007/s00726-012-1216-z
Effect of leukotriene inhibitors on evolution of experimental brain contusions
Voigt, C. L. M.; Donat, C. K.; Härtig, W.; Förschler, A.; Arendt, T.; et al. (7 authors)
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Neuropathology and Applied Neurobiology 38(2012)4, 354-366
DOI: 10.1111/j.1365-2990.2011.01211.x
Radiosynthesis of a 18F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo
Kniess, T.; Laube, M.; Bergmann, R.; Graf, F.; Steinbach, J.; et al. (7 authors)
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Bioorganic & Medicinal Chemistry 20(2012), 3410-3421
DOI: 10.1016/j.bmc.2012.04.022
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