Helmholtz-Zentrum Dresden-Rossendorf
Chemistry of the f-elements
PD Dr. habil. Moritz Schmidt
Head Chemistry of the f-elements
Phone
+49 351 260 3156, +49 351 260 2536
moritz.schmidthzdr.de
Link
ORCID: 0000-0002-8419-0811
Address
Building/Office
Bautzner Landstraße 400 - 01328 Dresden
801/P249, 850/16.1
Scientific career
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Current:Head of the department "Chemistry of the f-elements" Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Resource Ecology.
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2013 – 2018:Helmholtz Young Investigator group leader at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Resource Ecology.
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2012 – 2013:Research associate at the Karlsruhe Institute of Technology (KIT), Institute for Nuclear Waste Disposal.
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2010 – 2012:Research Associate at Argonne National Laboratory (ANL), Chemical Sciences and Engineering Division.
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11/2009:PhD at the University of Heidelberg, Department of Chemistry, “Untersuchungen zum Einbaumechanismus von Actiniden und Lanthaniden in Calcium-haltige Sekundärphasen” (in German).
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2006 – 2009:PhD student at the Forschungszentrum Karlsruhe, Institute for Nuclear Waste Disposal.
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2006:Diplom (M.Sc.) in Chemistry at the University of Heidelberg
Research experience
- Actinide chemistry
- Geochemistry of the actinides in the context of nuclear waste storage
- Mineral/water interface reactions
- Structural incorporation of actinides into mineral phases
- Site-selective time-resolved laser fluorescence spectroscopy with Cm(III) and Eu(III)
- Surface X-ray diffraction
Newest Publication in the Department
Preparation and characterization of Mn(II)Mn(III) complexes with relevance to class Ib ribonucleotide reductases
Doyle, L. M.; Bienenmann, R. L. M.; Gericke, R.; Xu, S.; Farquhar, E. R.; Que Jr, L.; McDonald, A. R.
Abstract
The Mn₂ complex (Mn(II)₂(TPDP)(O₂CPh)₂)(BPh₄) (1, TPDP = 1,3-bis(bis(pyridin-2-ylmethyl)amino)propan-2-ol, Ph = phenyl) was prepared and subsequently characterized via single-crystal X-ray diffraction, X-ray absorption, electronic absorption, and infrared spectroscopies, and mass spectrometry. 1 was prepared in order to explore its properties as a structural and functional mimic of class Ib ribonucleotide reductases (RNRs). 1 reacted with superoxide anion (O₂(•–)) to generate a peroxido-MnIIMnIII complex, 2. The electronic absorption and electron paramagnetic resonance (EPR) spectra of 2 were similar to previously published peroxido-Mn(II)Mn(III) species. Furthermore, X-ray near edge absorption structure (XANES) studies indicated the conversion of a Mn(II) 2 core in 1 to a Mn(II)Mn(III) state in 2. Treatment of 2 with para-toluenesulfonic acid (p-TsOH) resulted in the conversion to a new Mn(II)Mn(III) species, 3, rather than causing O—O bond scission, as previously encountered. 3 was characterized using electronic absorption, EPR, and X-ray absorption spectroscopies. Unlike other reported peroxido-Mn(II)Mn(III) species, 3 was capable of oxidative O—H activation, mirroring the generation of tyrosyl radical in class Ib RNRs, however without accessing the Mn(III)Mn(IV) state.
Keywords: Bioinorganic; Dimanganese cluster; Ribonucleotide reductase; Dioxygen activation; electron paramagnetic resonance
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Journal of Inorganic Biochemistry 257(2024), 112583
DOI: 10.1016/j.jinorgbio.2024.112583
Permalink: https://www.hzdr.de/publications/Publ-39110
Grants and Projects
- Bioinspired polyhydroxamic sequestering agents for the in vivo decorporation of actinides
(ActiDecorp, ANR/DFG, 04/2024-03/2027) - Actinide-metal-bonding at the atomic level
(Am-BALL, BMUV, 05/2023-04/2026) - Investigation of the interactions of f-elements with biologically-relevant structural motives: Determination of structure-effect principles for a mobilization in the environment
(FENABIUM-II, BMBF, 04/2023-03/2026) - Competition and Reversibility of sorption processes
(KuRSiV, BMUV, 01/2023-06/2026) - Spectroscopic characterization of f-Element complexes with soft donor ligands
(f-Char, BMBF, 10/2020 - 03/2024) - Structure effect relations between f-elements and organic ligands with natural-analogue binding modes in regards to a possible mobilization in the environment
(FENABIUM, BMBF, 10/2016 – 05/2021) - Smart-Kd applications for the long term safety assessment of nuclear waste disposal sites
(SMILE, BMWi, 09/2018 – 02/2022) - Helmholtz Young Investigator Group “Structures and reactivity at the aqueous/mineral interface”
(VH-NG-942, Helmholtz Association, 10/2013 - 09/2018)