Droplets microfluidics for clinical diagnostics
High throughput characterization of kinetics of biological and chemical processes, including tracking the proliferation of living cells or monitoring enzymatic activity, is a key task, particularly, in medical diagnostics, food processing and pharmaceutical industries. We propose the new format of the in vitro assay using nano- to femto-liter emulsion droplets in fluidics that helps to surpass the precision of conventional tests. In particular, the approach can be used to determine e.g. metabolic activity, division rate and drug sensitivity in fundamental microbiology research and clinical studies.
References:
- Baraban, Larysa & Bertholle, Fabien & Salverda, Merijn & Bremond, Nicolas & Panizza, Pascal & Baudry, Jean & de Visser, J Arjan & Bibette, Jérôme. (2011). Millifluidic droplet analyser for microbiology(2). Lab on a chip. 11. 4057-62. 10.1039/c1lc20545e.
- Illing, Rico & Burkart, Corinna & Pfitzner, Daniel & Jungmann, Dirk & Baraban, Larysa & Cuniberti, Gianaurelio. (2016). Ecotoxicity assessment using ciliate cells in millifluidic droplets. Biomicrofluidics(3). 10. 024115. 10.1063/1.4944869.
Inhalt aus Sidebar
Kontakt
Prof. Dr. Larysa Baraban
Leiterin Life Science Nanomikrosysteme
l.baraban
hzdr.de
Tel.: +49 351 260 3091
Fax: +49 351 260 13091
URL dieses Artikels
https://www.hzdr.de/db/Cms?pOid=68385
Links im Text
| (1) | https://www.hzdr.de/db/PicOri?pOid=62168 |
| (2) | https://pubs.rsc.org/en/content/articlehtml/2011/lc/c1lc20545e |
| (3) | https://aip.scitation.org/doi/full/10.1063/1.4944869 |
