Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf
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Type of publication | Articles ref. in Journals | Conference abstracts in ref. journals | Books | Proceedings | Wissenschaftlich-Technische Berichte/ HZDR-Reports | Lectures | Posters | Patents | Research data | Software | RODARE publications | |
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41875 Publications
Real-time Image Stream Algorithms: Core Library - libRISA_Core
Abstract
Real-time image stream algorithms (RISA) is a high-throughput, low-latency image stream processing command-line application. Based on a configuration file, it will construct a processing pipeline of distinct processing steps and process a given image stream. Implementations of such processing steps are loaded from RISA-compatible shared libraries.
The libRISA_Core library includes basic image processing algorithms, e.g., for filtering, masking, transforming (FFT) and displaying data.
Keywords: Real-time; Image processing; Data processing; CUDA; C++
Related publications
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Real-time Data Processing for Ultrafast X-Ray Computed Tomography using …
ROBIS: 34743 is supplemented by this (Id 34604) publication
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Software in external data repository
Publication year 2022
Programming language: C++, CUDA
System requirements: Linux-based operating system, CUDA-capable GPU
License: Apache-2.0 (Link to license text)
Hosted on https://gitlab.hzdr.de/risa/librisa_core: Link to location
Permalink: https://www.hzdr.de/publications/Publ-34604
Targeting CD10 on B-Cell Leukemia Using the Universal CAR T-Cell Platform (UniCAR)
Mitwasi, N.; Arndt, C.; Loureiro, L. R.; Kegler, A.; Fasslrinner, F.; Berndt, N.; Bergmann, R.; HoˇRejší, V.; Rössig, C.; Bachmann, M.; Feldmann, A.
Abstract
Chimeric antigen receptor (CAR)-expressing T-cells are without a doubt a breakthrough therapy for hematological malignancies. Despite their success, clinical experience has revealed several challenges, which include relapse after targeting single antigens such as CD19 in the case of B-cell acute lymphoblastic leukemia (B-ALL), and the occurrence of side effects that could be severe in some cases. Therefore, it became clear that improved safety approaches, and targeting multiple antigens, should be considered to further improve CAR T-cell therapy for B-ALL. In this paper, we address both issues by investigating the use of CD10 as a therapeutic target for B-ALL with our switchable UniCAR system. The UniCAR platform is a modular platform that depends on the presence of two elements to function. These include UniCAR T-cells and the target modules (TMs), which cross-link the T-cells to their respective targets on tumor cells. The TMs function as keys that control the switchability of UniCAR T-cells. Here, we demonstrate that UniCAR T-cells, armed with anti-CD10 TM, can efficiently kill B-ALL cell lines, as well as patient-derived B-ALL blasts, thereby highlighting the exciting possibility for using CD10 as an emerging therapeutic target for B-cell malignancies.
Keywords: CD10; immunotherapy; CAR T-cells
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International Journal of Molecular Sciences 23(2022)9, 4920
DOI: 10.3390/ijms23094920
Cited 3 times in Scopus
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Permalink: https://www.hzdr.de/publications/Publ-34603
Teaching Workshop: Software Carpentry Workshop, Unix shell, Git, and Programming with Python
Zongru Doris Shao, R. H.
Abstract
Teaching Software Carpentry Workshop
Keywords: Python; Git; Shell
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Lecture (others) (Online presentation)
Software Carpentry Workshop, 16.-19.05.2022, University of Twente, online, Netherlands
Downloads
Permalink: https://www.hzdr.de/publications/Publ-34602
Personnel staffing and scheduling during COVID-19 pandemic: A contact network-based analysis
Batista German, A. C.; Senapati, A.; Davoodi Monfared, M.; Calabrese, J.
Abstract
The COVID-19 pandemic has disrupted global operations, compromising people's health and safety. Several organizations, in particular, have been forced to shift their operations to a hybrid system (working from home) to prevent the spread of the virus and ensure employee safety. Although working from home is effective for some organizations, others need to find a balance between workplace occupancy and risk of infection to keep their operations functioning efficiently. We address this issue through contact network analysis by investigating the impact of employee interactions on virus spread in closed environments. We develop a staffing model for the scheduling of employees, considering contact networks. The goal is to maximize occupancy while minimizing the risk of infection. We aim to find the optimal composition of staff differing by priority to be allocated over a specified discrete-time horizon. We propose a Mixed Integer Non-Linear Programming (MINLP) model considering a Microscopic Markov Chain Approach (MMCA) to determine the probability of infection in a contact network based on the employee’s interactions. We assess the effectiveness of the approach through simulation, considering several contact network structures and interventions such as testing, vaccination, and personal protection. Through extensive computational analysis, we show that workplace occupancy can be efficiently balanced while keeping safety in the workplace.
Keywords: scheduling; optimization; disease modeling; Markov Chain
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Lecture (Conference)
48th Annual Meeting of the Euro Working Group on Operational Research Applied to Health Services, 17.-22.07.2022, Bergamo, Italy
Permalink: https://www.hzdr.de/publications/Publ-34601
Therapeutic potential of repetitive AC-magnetic treatments on iPSC-derived motoneurons from ALS patients to improve axonal regeneration
Kandhavivorn, W.
Abstract
lecture seminar for Ph.D. candidates at Center for Radiopharmaceutical Tumor Research (ZRT), HZDR
es hat keine Inhaltsangabe dafür vorgelegen
Involved research facilities
- High Magnetic Field Laboratory (HLD)
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Lecture (others)
(Online presentation)
Lecture Seminar for Ph.D. candidates at Center for Radiopharmaceutical Tumor Research (ZRT), HZDR, 25.04.2022, Dresden, Deutschland
Permalink: https://www.hzdr.de/publications/Publ-34600
The application of AC-magnetic stimulations on iPSC-derived motoneurons from ALS patients to improve axonal regeneration for therapeutic potential in neurodegeneration
Kandhavivorn, W.
Abstract
lecture in EGBE 693 Research Seminar for Biomedical Engineering II for graduate students at the Department of Biomedical Engineering, Faculty of Engineering, Mahidol University Thailand
es hat keine Inhaltsangabe dafür vorgelegen
Involved research facilities
- High Magnetic Field Laboratory (HLD)
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Lecture (Conference)
(Online presentation)
EGBE 693 Research Seminar for Biomedical Engineering II for graduate students, 18.01.2022, Nakhon Pathom, Thailand
Permalink: https://www.hzdr.de/publications/Publ-34599
Radiomics-based differentiation of lung disease models generated by polluted air based on X-ray computed tomography data
Szigeti, K.; Szabó, T.; Korom, C.; Ilona, C.; Horváth, I.; Veres, D. S.; Gyöngyi, Z.; Karlinger, K.; Bergmann, R.; Pócsik, M.; Budán, F.; Máthé, D.
Abstract
Background: Lung diseases (resulting from air pollution) require a widely accessible method for risk estimation and arly diagnosis to ensure proper and responsive treatment. Radiomics-based fractal dimension analysis of X-ray computed tomography attenuation patterns in chest voxels of mice exposed to different air polluting agents was performed to model early stages of disease and establish differential diagnosis.
Methods: To model different types of air pollution, BALBc/ByJ mouse groups were exposed to cigarette smoke combined with ozone, sulphur dioxide gas and a control group was established. Two weeks after exposure, the frequency distributions of image voxel attenuation data were evaluated. Specific cut-off ranges were defined to group voxels by attenuation. Cut-off ranges were binarized and their spatial pattern was associated with calculated fractal dimension, then abstracted by the fractal dimension – cut-off range mathematical function. Nonparametric
Kruskal-Wallis (KW) and Mann–Whitney post hoc (MWph) tests were used.
Results: Each cut-off range versus fractal dimension function plot was found to contain two distinctive Gaussian curves. The ratios of the Gaussian curve parameters are considerably significant and are statistically distinguishable within the three exposure groups.
Conclusions: A new radiomics evaluation method was established based on analysis of the fractal dimension of chest X-ray computed tomography data segments. The specific attenuation patterns calculated utilizing our method may diagnose and monitor certain lung diseases, such as chronic obstructive pulmonary disease (COPD), asthma, tuberculosis or lung carcinomas.
Keywords: Fractal dimension; Radiomics; In vivo micro-CT; Air pollution; Lung disease
Involved research facilities
- PET-Center
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BMC Medical Imaging 16(2016), 14
DOI: 10.1186/s12880-016-0118-z
Cited 15 times in Scopus
Downloads
Permalink: https://www.hzdr.de/publications/Publ-34597
Euler-Euler / RANS Modeling of Solid-liquid Flow in Stirred Tanks: a Comprehensive Model Validation
Shi, P.; Sommer, A.-E.; Rox, H.; Eckert, K.; Rzehak, R.
Abstract
Simulations of solid-liquid flow on industrial scales are feasible within the Euler-Euler / RANS approach. The reliability of this approach depends largely on the closure models applied to describe the unresolved phenomena at the particle scale, in particular the interfacial forces. In this work, a set of closure models assembled previously for this kind of application (Shi and Rzehak 2020) is further validated by comparing the predictions to a recent experiment on stirred-tank flows (Sommer et al. 2021), which focuses on dilute suspensions. The dataset used for validation comprises 14 different experimental cases, covering a wide range of particle slip Reynolds number, impeller Reynolds number, and particle Stokes number. For each case, simulation results on the solid velocity and volume fraction as well as liquid velocity and turbulence are compared with the experimental data. It turns out that by and large the experimental data are reasonably well reproduced. However, the measurements show a small but clear effect of modulation of the liquid phase turbulence by the particles. Therefore, several particle-induced turbulence (PIT) models based on the available literature are assessed as well. Our results indicate a reduction in the predicted fluctuations by all PIT models, which improves the results in cases with turbulence suppression but deteriorates those with turbulence augmentation.
Keywords: stirred tanks; solid-liquid flow; Euler-Euler two-fluid model; Reynolds-stress turbulence model; particle-induced turbulence
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Minerals Engineering 185(2022), 107679
DOI: 10.1016/j.mineng.2022.107679
Cited 2 times in Scopus
Downloads
- Final Draft PDF 2,1 MB Secondary publication
Permalink: https://www.hzdr.de/publications/Publ-34596
Data: Temperature Driven Transformation of the Flexible Metal-Organic Framework DUT-8(Ni)
Ehrling, S.; Senkovska, I.; Efimova, A.; Bon, V.; Abylgazina, L.; Petkov, P.; Evans, J. D.; Elsherif, A. G. A.; Thomas Wharmby, M.; Roslova, M.; Huang, Z.; Tanaka, H.; Wagner, A.; Schmidt, P.; Kaskel, S.
Abstract
These are the raw data of "Temperature Driven Transformation of the Flexible Metal-Organic Framework DUT-8(Ni)"
DUT-8(Ni) metal-organic framework belongs to the family of flexible pillared layer materials. The desolvated framework can be obtained in the open pore form (op) or in the closed pore form (cp), depending on the crystal size regime. In the present work, we report on the behaviour of desolvated DUT-8(Ni) at elevated temperatures.
For both, op and cp variants, heating causes a structural transition, leading to an new, crystalline compound, containing two
interpenetrated networks. The state of the framework before transition (op vs. cp) influences the transition temperature: the small particles of the op phase transform at significantly lower temperature in comparison to the macroparticles of the cp phase, transforming close to the decomposition temperature. The new compound, confined closed pore phase (ccp), was characterized by powder X-ray diffraction and spectroscopic techniques, such as IR, EXAFS, and positron annihilation lifetime spectroscopy (PALS). Thermal effects of structural cp to ccp transitions were studied using differential scanning calorimetry (DSC), showing an overall exothermic effect of the process, involving bond breaking and reformation. Theoretical calculations reveal the energetics, driving the observed temperature induced phase transition.
Keywords: thermal response • interpenetrated MOF • thermal effect • phase transition • bond rearrangement
Related publications
- DOI: 10.1002/chem.202201281 references this (Id 34595) publication
- URL: https://www.hzdr.de/db/!Publications?pNid=head&pSelMenu=0&pSelTitle=34576 documents this (Id 34595) publication
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Temperature Driven Transformation of the Flexible Metal-Organic Framework …
ROBIS: 34575 has used this (Id 34595) publication of HZDR-primary research data
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Reseach data in the HZDR data repository RODARE
Publication date: 2022-04-29 Open access
DOI: 10.14278/rodare.1549
Versions: 10.14278/rodare.1550
License: CC-BY-1.0
Downloads
Permalink: https://www.hzdr.de/publications/Publ-34595
The nature of π-hole interaction between iodide anion and quinoid ring in the crystalline state
Milašinović, V.; Vedran Vuković, V.; Krawczuk, A.; Krešimir Molčanov, K.; Hennig, C.; Bodensteiner, M.
Abstract
Abstract The investigated co-crystal of 3-chloro-N-methylpyridinium iodide with tetrabromoquinone (3−Cl−N−MePy∙I∙Br4Q) reveals a π-hole interaction between an iodide anion and a quinoid ring involving a n→π* charge transfer. The quinoid ring has a partial negative charge (estimated to be in the range of 0.08 to 0.11 e) and a partial radical character, which is related to black colour of the crystals (the crystals of neutral tetrabromoquinone are yellow). A detailed X-ray charge density study revealed two symmetry-independent bonding critical points between the iodide and carbon atoms of the ring. Their maximum electron density of 0.065 e Å−3 was reproduced by quantum chemical modelling. Energy of the interaction is estimated to be −11.16 kcal mol−1, which is comparable to the strength of moderate hydrogen bonding (about −10 kcal mol−1); it is dominantly of electrostatic nature, with a considerable dispersion component.
Keywords: π-hole interactions; charge transfer; quinone; charge density; atoms-in-molecule
Involved research facilities
- Rossendorf Beamline at ESRF DOI: 10.1107/S1600577520014265
Related publications
- DOI: 10.1107/S1600577520014265 is cited by this (Id 34594) publication
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IUCrJ 23(2023), 156-163
DOI: 10.1107/S2052252523000052
Cited 7 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34594
Real-time Image Stream Algorithms - RISA
Abstract
Real-time image stream algorithms (RISA) is a high-throughput, low-latency image stream processing command-line application. Based on a configuration file, it will construct a processing pipeline of distinct processing steps and process a given image stream. Implementations of such processing steps are loaded from RISA-compatible shared libraries.
Keywords: Real-time; Image processing; Data processing; CUDA; C++
Related publications
-
Real-time Data Processing for Ultrafast X-Ray Computed Tomography using …
ROBIS: 34743 is supplemented by this (Id 34593) publication
-
Software in external data repository
Publication year 2022
Programming language: C++, CUDA
System requirements: Linux-based operating system, CUDA-capable GPU
License: Apache-2.0 (Link to license text)
Hosted on https://gitlab.hzdr.de/risa/RISA: Link to location
Permalink: https://www.hzdr.de/publications/Publ-34593
Data: Fully encapsulated and stable black phosphorus field-effect transistors
Arora, H.; Fekri, Z.; Vekariya, Y. N.; Chava, P.; Watanabe, K.; Taniguchi, T.; Helm, M.; Erbe, A.
Abstract
Fabricated devices went through electrical characterization with 4200-SCS parameter analyzer located in greyroom and Agilent 4156C Parameter Analyzer equipped with a cool-down setup located in 613. The measured data was processed with origin software.
Keywords: two-dimensional semiconductors; black phosphorus; field-effect transistors; hexagonal boron nitride; encapsulation
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34592) publication
- DOI: 10.1002/admt.202200546 references this (Id 34592) publication
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Fully encapsulated and stable black phosphorus field-effect transistors
ROBIS: 34502 has used this (Id 34592) publication of HZDR-primary research data
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Reseach data in the HZDR data repository RODARE
Publication date: 2022-04-29 Open access
DOI: 10.14278/rodare.1551
Versions: 10.14278/rodare.1552
License: CC-BY-4.0
Downloads
Permalink: https://www.hzdr.de/publications/Publ-34592
Expanding the Range: AuCu Metal Aerogels from H2O and EtOH
Georgi, M.; Kresse, J.; Hiekel, K.; Hübner, R.; Eychmüller, A.
Abstract
Due to their self-supporting and nanoparticulate structure, metal aerogels have emerged as excellent electrocatalysts, especially in the light of the shift to renewable energy cycles. While a large number of synthesis parameters have already been studied in depth, only superficial attention has been paid to the solvent. In order to investigate the influence of this parameter with respect to the gelation time, crystallinity, morphology, or porosity of metal gels, AuxCuy aerogels were prepared in water and ethanol. It was shown that although gelation in water leads to highly porous gels (60 m2g-1), a CuO phase forms during this process. The undesired oxide could be selectively removed using a post-washing step with formic acid. In contrast, the solvent change to EtOH led to a halving of the gelation time and the suppression of Cu oxidation. Thus, pure Cu aerogels were synthesized in addition to various bimetallic Au3X (X = Ni, Fe, Co) gels. The faster gelation, caused by the lower permittivity of EtOH, led to the formation of thicker gel strands, which resulted in a lower porosity of the AuxCuy aerogels. The advantage given by the solvent choice simplifies the preparation of metal aerogels and provides deeper knowledge about their gelation.
Keywords: metal; aerogel; gold; copper; ethanol; water; solvent; bimetallic; porous; one-step
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34591) publication
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Catalysts 12(2022)4, 441
DOI: 10.3390/catal12040441
Cited 4 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34591
Bioleaching of metal(loid)s from sulfidic mine tailings and waste rock from the Neves Corvo mine, Portugal, by an acidophilic consortium
Opara, C. B.; Blannin, R.; Ebert, D.; Frenzel, M.; Pollmann, K.; Kutschke, S.
Abstract
Sulfidic mine waste usually contains elevated amounts of valuable and hazardous metal(loid)s, which may pose environmental risks but can also provide opportunities for resource recovery. Reprocessing of mine waste can offer both economic and environmental benefits by supplying some of the ever-growing global demand for valuable metals, as well as reducing environmental risks. The present study aimed to simultaneously recover both valuable and hazardous metal(loid)s from two sulfidic mine waste samples (waste rock (NC_01) and tailings (NC_02)) from the Neves Corvo mine, Portugal, using a novel acidophilic consortium dominated by iron-oxidizing Leptospirillum genus and Acidiphilium sp. Bioleaching results showed that over 70% of the total Zn, Co, In, As, and Cd contents of NC_01 and NC_02 were leached within 21 days, while 55% – 62% Mn was leached. Copper behaved in a refractory manner, as only 33% and 21% Cu were leached from NC_01 and NC_02, respectively. X-ray diffraction (XRD) and Scanning electron microscope-based automated image analyses (SEM/MLA-GXMAP) of the bioleached residues revealed an almost complete absence of residual pyrite in NC_01 and a reduction of pyrite in NC-02, as well as the formation of secondary minerals, especially jarosite. In most cases, the biogenic jarosite co-precipitated some of the leached elements again, e.g., Cu and Pb. In conclusion, a synchronized method for bioleaching valuable and hazardous metal(loid)s was developed using a novel acidophilic consortium, thereby demonstrating the potential for the generation of economic value and environmental risk reduction for sulfidic mine waste samples.
Keywords: Bioleaching; Acidophiles; Metal(loid)s; Minerals; Sulfidic tailings; Sulfidic waste rock; SEM/MLA-GXMAP; XRD
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Minerals Engineering 188(2022), 107831
DOI: 10.1016/j.mineng.2022.107831
Cited 10 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34590
Identification of geochemical and biological processes controlling naturally occurring radionuclides (NOR) mobility to derive more robust solid/liquid distribution coefficients (Kd)
Arnold, T.; Bok, F.; Cazala, C.; Coppin, F.; Fevrier, L.; Katz, A.; Krawczyk-Bärsch, E.; Landesman, C.; Mangeret, A.; Marsal, F.; Merroun, M. L.; Montavon, G.; Nivesse, A.-L.; Pelkonen, M.; Pérez-Sánchez, D.; Rigol, A.; Sachs, S.; Skipperud, L.; Urso, L.; Veilly, E.; Vidal, M.
Abstract
Geochemical and biological processes controlling NOR mobility are studied within the RadoNorm project to derive more robust distribution coefficients Kd. To achieve this (i) the effect of microorganisms on NOR mobility in uranium (U) mine waters is studied, (ii) new datasets of NOR sorption and desorption parameters are acquired, (iii) a methodology for the determination of site-specific Kd values is evolved and (iv) models able to predict Kd (NOR) in relevant scenarios are developed.
The impact of microbes on the speciation of U in U mine waters is characterized by a multidisciplinary approach providing insights into the microbe/U interaction mechanisms needed to predict the effect of microbial processes on the mobility of this radionuclide.
Laboratory studies are performed to identify the soil properties that govern NOR interactions in soils. Sorption and desorption Kds for representative soils are determined, also considering soil aging effects. Chemical analogy between NOR and stable elements (e.g., Ba vs. Ra) is also examined, with new data and additional values gathered from literature.
Considering the dynamics of sorption-desorption reactions, studies are carried out at the Zatu site (France) to develop a method to determine site-specific Kds. Experiments with soil core samples are performed to determine the amount of desorbed U, Ra and Pb and to derive apparent Kd values. The validity of this approach will be confirmed combining these results with in situ studies (Zatu site).
Two approaches are followed to derive models for Kd (NOR) prediction. The first one is the “smart Kd” model, which is based on a realistic description of chemical reactions of NOR in liquid and solid phases. The second one is constructing simple, multivariate Kd prediction models based on soil properties governing NOR interaction. Water transport models with different levels of complexity are applied to describe the transport of NOR at the Zatu site in consistency with site-specific Kds.
Keywords: Naturally occurring radionuclides; NORM; Uranium; Radium; Sorption; Transport; Distribution coefficients; Modeling; Geochemical processes; Biological processes
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Lecture (Conference)
European Radiation Protection Week 2022, 09.-14.10.2022, Estoril, Portugal
Permalink: https://www.hzdr.de/publications/Publ-34589
(Data set) Optical study of RbV₃Sb₅: Multiple density-wave gaps and phonon anomalies
Wenzel, M.; Ortiz, B. R.; Wilson, S. D.; Dressel, M.; Tsirlin, A. A.; Uykur, E.
Abstract
The folder contains the data set that the publication with the same name is based on.
Origin file:
- Reflectivity
- Optical conductivity
- Band resolved DFT calculation (band structure + optical conductivity)
- Comparison of DFT and experiment (interband transitions) above and below CDW transition
- Further data sets are available upon request
Related publications
- DOI: 10.1103/PhysRevB.105.245123 references this (Id 34588) publication
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Optical study of RbV₃Sb₅: Multiple density-wave gaps and phonon anomalies
ROBIS: 34255 references this (Id 34588) publication -
Optical study of RbV₃Sb₅: Multiple density-wave gaps and phonon anomalies
DOI: 10.48550/arXiv.2112.07501 is compiled/create by this (Id 34588) publication -
Optical study of RbV₃Sb₅: Multiple density-wave gaps and phonon anomalies
ROBIS: 34255 has used this (Id 34588) publication of HZDR-primary research data
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Reseach data in the HZDR data repository RODARE
Publication date: 2022-04-28 Restricted access
DOI: 10.14278/rodare.1545
Versions: 10.14278/rodare.1546
Downloads
Permalink: https://www.hzdr.de/publications/Publ-34588
Scaling Laser-Plasma Electron Accelerators to 100GeV-scale Energies using TWEAC and Multi-Petawatt Lasers
Debus, A.; Steiniger, K.; Schramm, U.
Abstract
The quest for advanced acceleration techniques for providing more compact accelerators is a grand challenge of particle accelerator physics. Addressing this challenge will allow to further scale up energies for high-energy physics, as well as enable accelerator technology to be more commonly available.
Despite tremendous advances in Laser-Plasma accelerators (LPAs) with respect to beam energy, quality, charge and stability, sustaining scalability of compact LPAs to even higher electron energies and more brilliant secondary radiation sources is one of the yet to be solved key challenges of the field.
These limitations can be overcome by TWEAC (Traveling-Wave Electron ACceleration), a novel laser-plasma interaction geometry relying on spatio-temporally shaped ultrashort, high-power laser pulses using existing laser technology. These laser pulses provide "flying" focal regions propagating at tuneable velocities close to the speed of light without the need for external guiding.
Multi-petawatt laser facilities together with TWEAC pave the way towards scalable LPAs on the 100GeV scale without the need for multiple laser-accelerator stages.
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Contribution to WWW
White Paper for Multi-Petawatt Physics Prioritization workshop. White papers formulate potential scientific goals and flagship experiments, diagnostic needs and strategies, and visions for what a next-generation facility might require.: http://www.lle.rochester.edu/media/conferences/MP3/MP3wWhitePapers.pdf
Permalink: https://www.hzdr.de/publications/Publ-34587
Petawatt Class Lasers for Realizing Optical Free-Electron Lasers with Traveling-Wave Thomson-Scattering
Steiniger, K.; Debus, A.; Schramm, U.
Abstract
Traveling-Wave Thomson-Scattering (TWTS) is a scheme for the realization of optical free-electron lasers (OFELs) from the interaction of ultra-short, high-power laser pulses with relativistic electrons.
The laser pulse thereby provides the undulator field which typically needs to include a few 100 to several 1000 undulator periods for OFEL operation.
Such long optical undulators are realized in TWTS by the combination of a side-scattering geometry where electron and laser pulse propagation directions enclose the interaction angle $\phi$ and a laser pulse-front tilt $\alpha_\A{tilt} = \phi/2$ of half the interaction angle.
This combination of side-scattering and pulse-front tilt ensures continuous overlap of electrons and laser pulse during the passage of the electrons through the laser pulse.
Interaction durations between laser pulse, electrons, and their emitted radiation can be long enough to initiate microbunching of the electron pulse and subsequent coherent amplification of radiation provided electron and laser pulse are of sufficient quality.
Requirements on electron and laser pulse quality can be met for VUV TWTS OFELs with existing technology already today and higher power laser pulses enable TWTS OFELs at shorter wavelength, e.\,g.\ EUV TWTS OFELs.
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Contribution to WWW
White Paper for Multi-Petawatt Physics Prioritization workshop. White papers formulate potential scientific goals and flagship experiments, diagnostic needs and strategies, and visions for what a next-generation facility might require.: http://www.lle.rochester.edu/media/conferences/MP3/MP3wWhitePapers.pdf
Permalink: https://www.hzdr.de/publications/Publ-34586
Atomically Dispersed Pentacoordinated-Zirconium Catalyst with Axial Oxygen Ligand for Oxygen Reduction Reaction
Wang, X.; An, Y.; Liu, L.; Fang, L.; Liu, Y.; Zhang, J.; Qi, H.; Li, T.; Heine, T.; Kuc, A. B.; Yu, M.; Feng, X.
Abstract
Single-atom catalysts (SACs), affording extraordinary catalytic activity per site, represent promising alternatives to the commercial platinum-based electrocatalysts towards oxygen reduction reaction (ORR). Yet, the common in-plane coordination configuration limits platinum-competitive SACs to few transition metal elements with low metal loading (< 5 wt%). Here, we report the discovery of an ORR-efficient Zr-based SAC (denoted O-Zr-N-C), which consists of unique pentacoordinated Zr sites with nontrivial axial O ligands. The axial O ligand with the desirable electron-withdrawing effect downshifts the d-band center of Zr and confers single-atom Zr sites with stable local structure and proper adsorption capability for O-containing intermediates. Consequently, the ORR performance of O-Zr-N-C electrocatalyst in alkaline condition prominently surpasses that of commercial Pt/C, achieving a half-wave potential of 0.91 V vs. reversible hydrogen electrode, a kinetic current density of 76.0 mA cm–2, and outstanding durability (92% current retention after 130-hour operation). Moreover, the pentacoordinated Zr site shows good resistance towards aggregation, enabling the synthesis of O-Zr-N-C with high single atom Zr loading (9.1 wt%). With the high loading catalyst, the assembled zinc-air battery (ZAB) delivers a record-high power density of 324 mW cm−2 among those of SAC-based ZABs. This work not only provides a new member of ORR-active SACs, but also sheds light on the atomic-level design of advanced electrocatalysts.
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Angewandte Chemie - International Edition 61(2022)36, e202209746
DOI: 10.1002/anie.202209746
Cited 58 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34585
Interlayer excitons in MoSe2/2D perovskite hybrid heterostructures – the interplay between charge and energy transfer
Karpińska, M.; Jasiński, J.; Kempt, R.; Ziegler, J. D.; Sansom, H.; Snaith, H. J.; Taniguchi, T.; Watanabe, K.; Surrente, A.; Dyksik, M.; Maude, D. K.; Kłopotowski, Ł.; Chernikov, A.; Kuc, A. B.; Baranowski, M.; Plochocka, P.
Abstract
Van der Waals crystals have opened a new and exciting chapter in heterostructure research, removing lattice matching constraints characteristic of epitaxial semiconductors. They provide unprecedented flexibility for heterostructure design. Combining 2D perovskites with other 2D materials, in particular transition metal dichalcogenides (TMDs) has recently emerged as an intriguing way to design hybrid opto- electronic devices. However, the excitation transfer mechanism between the layers (charge or energy transfer) remains to be elucidated. Here we investigate PEA2PbI4/MoSe2 and (BA)2PbI4/MoSe2 heterostructures by combining optical spectroscopy and density functional theory (DFT) calculations. We show that the band alignment facilitates charge transfer. Namely, holes are transferred from the TMD to the 2D perovskite, while the electron transfer is blocked, resulting in the formation of inter-layer excitons. Moreover, we show that the energy transfer mechanism can be turned on by an appropriate alignment of the excitonic states, providing a rule of thumb for the deterministic control of the excitation transfer mechanism in TMD/2D-perovskite heterostructures.
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Nanoscale 14(2022), 8085-8094
DOI: 10.1039/D2NR00877G
Cited 11 times in Scopus
Downloads
- Final Draft PDF 1,5 MB Secondary publication
Permalink: https://www.hzdr.de/publications/Publ-34584
On the prospects of magnetic-field-assisted electrodeposition of nano-structured ferromagnetic layers
Huang, M.; Skibinska, K.; Zabinski, P.; Wojnicki, M.; Wloch, G.; Eckert, K.; Mutschke, G.
Abstract
Micro- and nano-structured ferromagnetic layers are attractive for super-hydrophobic and electrocatalytic applications and can be effectively synthesized using electrodeposition. Beside the use of capping agents, magnetic fields have recently been proven to promote the growth of mm-sized conical structures by alternatively generating a supportive local flow. Here we explore the prospects of using magnetic fields to support the growth of smaller, micro-/nano-sized conical structures. We first elaborate by numerical simulations how the local electrolyte flow and the related inhomogeneous mass transfer change with shrinking cone size. Related scaling laws are derived, and stronger viscous friction along with smaller concentration changes inside the diffusion layer are found to limit the support of the magnetic field. To enhance the structuring effect, pulsed electrodeposition and use of superconducting magnets are discussed. Second, systematic experiments on the template-free electrodeposition of nickel layers in magnetic fields of different orientations and intensities are performed. Regardless of the direction, strong fields are found to promote blunt-ended, shell-like structures. These results are finally discussed by the help of numerical simulations which additionally consider the global cell flow forced by the magnetic fields. Importantly, global flow is found to dominate compared to local flow. We therefore propose improved electrode geometries for future research to clarify the prospects of stronger magnetic fields.
Keywords: ferromagnetic metal electrodeposition; magnetic field; nano-structured catalyst; numerical simulation; micro MHD effect
Related publications
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Numerical simulation of metal electrodeposition under the influence of a …
ROBIS: 34750 is supplemented by this (Id 34582) publication
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Electrochimica Acta 420(2022), 140422
DOI: 10.1016/j.electacta.2022.140422
Cited 18 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34582
Radiopharmazie des vergangenen Jahrzehnts
Abstract
Die Radiochemiker/Radiopharmazeuten des deutschsprachigen Raums sind im Verbund der AGRR – der „Arbeitsgemeinschaft Radiochemie und Radiopharmazie“ – innerhalb der Deutschen Gesellschaft für Nuklearmedizin organisiert. Die AGRR setzt sich vorrangig aus Kolleginnen und Kollegen der D-A-CH-Länder zusammen, sodass auf radiopharmazeutischer Seite eine Anbindung an die OGNMB und SGNM besteht. Sie pflegen dort – auch mit zahlreichen Mitgliedern aus der Industrie – während der jährlichen Arbeitstagungen einen intensiven Austausch, der über die Grenzen klassischer Vortragsveranstaltungen hinausgeht und so zu einer engen Vernetzung beiträgt. Neben klassisch-fachlichen Fragen bietet die AGRR eine Plattform zur Behandlung der vielen regulatorischen Probleme, die sowohl die pharmazeutischen als auch die Strahlenschutz-bezogenen Herausforderungen zur sicheren Versorgung der Nuklearmedizin mit anwendungsfertigen Radiopharmaka mit sich bringen.
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Nuklearmedizin 61(2022)02, 77-79
DOI: 10.1055/a-1780-1490
Permalink: https://www.hzdr.de/publications/Publ-34581
Speciation and spatial distribution of Eu(III) in fungal mycelium
Günther, A.; Wollenberg, A.; Vogel, M.; Drobot, B.; Steudtner, R.; Freitag, L.; Hübner, R.; Stumpf, T.; Raff, J.
Abstract
Europium, as an easy-to-study analog of the trivalent actinides, is of particular importance for studying the behavior of lanthanides and actinides in the environment. Since different soil organisms can influence the migration behavior of these elements, a detailed knowledge of these interaction mechanisms is important. The aim of this study was to investigate the interaction of mycelia of selected wood-inhabiting (S. commune, P. ostreatus, L. tigrinus) and soil-inhabiting fungi (L. naucinus) with Eu(III). In addition to determining the Eu(III) complexes in the sorption solution, the formed Eu(III) fungal species were characterized using scanning transmission electron microscopy coupled with energy-dispersive X-ray spectroscopy, chemical microscopy in combination with the time-resolved laser-induced fluorescence spectroscopy. Our data show that S. commune exhibited significantly higher Eu(III) binding capacity in comparison to the other fungi. Depending on fungal strain, the metal was immobilized on the cell surface, in the cell membranes, and within the membranes of various organelles, or in the cytoplasm in some cases. During the bioassociation process two different Eu(III) fungal species were formed in all investigated fungal strain. The phosphate groups of organic ligands were identified as being important functional groups to bind Eu(III) and thus immobilize the metal in the fungal matrix. The information obtained contributes to a better understanding of the role of fungi in migration, removal or retention mechanisms of rare earth elements and trivalent actinides in the environment.
Keywords: Fungi; Europium; Speciation; Scanning transmission electron microscopy (STEM); Chemical microscopy; Time-resolved laser-induced fluorescence spectroscopy (TRLFS)
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Science of the Total Environment 851(2022), 158160
DOI: 10.1016/j.scitotenv.2022.158160
Cited 3 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34580
Coupling between ferromagnetic and ferroelastic transitions and ordering in Heusler alloys produces new multifunctionality
Oleg, H.; Hanuš, S.; Fähler, S.
Abstract
The ability of Heusler alloys to accommodate broad variations of composition, doping
and ordering provides multiple options for tailoring their ferromagnetic and ferroelastic
properties. Moreover, existing coupling between these ferroic properties ranging from
coupled ferroic transitions to a coupling of their ferromagnetic and ferroelastic
microstructure allows for manifold multifunctionalities. Here we focus on ferromagnetic,
metamagnetic and reentrant shape memory alloys explaining the principles and sketch
effects’ rich susceptibility to temperature, magnetic field and stress. We illustrate how
these can provide a path to a multitude of emerging applications for actuation, sensing,
and energy use. As an outlook, we discuss time dependency, fatigue, and finite size
effects, which are not yet fully explored.
Keywords: Heusler Alloys; Functional magnetic materials; Magnetic shape memory alloys
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MRS Bulletin 47(2022)6, 618-627
DOI: 10.1557/s43577-022-00354-x
Cited 10 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34579
New concepts for recovery of metals from wastes using biological means
Pollmann, K.; Lederer, F.; Schönberger, N.; Jain, R.; Chakankar, M. V.; Kutschke, S.
Abstract
The development of new technologies, especially in the field of renewable energies, has led to an increase in the demand for essential metals in recent years. At the same time, the extraction of these metals is not always environmentally friendly. Toxic metals can pollute waters and enter the environment both during extraction and processing or through disposal. Therefore, new environmentally friendly technologies are needed that prevent their entry into the environment or efficiently contribute to the recovery and recycling of the elements. Biotechnology can contribute to this.
Such technologies exploit the natural ability of organisms, bio-components, and biomolecules to interact with metals. Furthermore, modern methods of molecular biology and synthetic biology enable the development of tailored biomolecules that interact with metal ions or surfaces. In this talk, some of these modern biotechnological concepts for metal extraction such as bioleaching, bioflotation, biosorption from various primary and secondary raw materials as well as for treatment of metal contaminated waste waters will be presented.
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Lecture (Conference)
(Online presentation)
ACS Spring 2022, 20.-24.03.2022, San Diego, CA, USA
Permalink: https://www.hzdr.de/publications/Publ-34578
Temperature Driven Transformation of the Flexible Metal-Organic Framework DUT-8(Ni)
Ehrling, S.; Senkovska, I.; Efimova, A.; Bon, V.; Abylgazina, L.; Petkov, P.; Evans, J. D.; Attallah, A. G.; Thomas Wharmby, M.; Roslova, M.; Huang, Z.; Tanaka, H.; Wagner, A.; Schmidt, P.; Kaskel, S.
Abstract
DUT-8(Ni) belongs to the flexible pillared layer MOFs, which solvent free variant can exist in the open pore (op, rigid) form or in the closed pore (cp, flexible) form depending on the crystal size regime. In present work, we report on response of desolvated DUT-8(Ni) against elevated temperature. For both variants, heating leads to structural transition, involving interpenetration of the framework and resulting in a new crystalline contracted closed pore phase (DUT-8(Ni)_ccp). The new compound was characterized by powder X-ray diffraction and spectroscopic techniques, such as IR, Raman spectroscopy, EXAFS and positron annihilation lifetime spectroscopy (PALS). State of the framework before transition (op vs. cp) influences the transition temperature: the small particles of the op phase transform at significantly lower temperature in comparison to the macroparticles of the cp phase, transforming just before decomposition. Thermal effects of structural cp to ccp transitions were studied using differential scanning calorimetry (DSC), showing an overall exothermic effect of the process, necessarily involving bond breaking and reformation. The theoretical calculations reveal the energetics driving the observed temperature induced phase transition.
Keywords: bond rearrangement; nterpenetrated MOF; hase transitio; thermal response; hermally-induced phase transformation
Involved research facilities
- P-ELBE
Related publications
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Data: Temperature Driven Transformation of the Flexible Metal-Organic …
ROBIS: 34595 HZDR-primary research data are used by this (Id 34575) publication
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Chemistry - A European Journal 28(2022)55, e202201281
DOI: 10.1002/chem.202201281
Cited 7 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34575
Atherosclerotic risk is associated with cerebral perfusion – a cross-sectional study using arterial spin labelling MRI
Hafdi, M.; Mutsaerts, H. J.; Petr, J.; Richard, E.; van Dalen, J. W.
Abstract
Non-invasive measurement of cerebral perfusion is promising for identifying individuals at high risk of cerebrovascular disease for prevention strategies. We tested whether the new and easily calculated arterial spin labelling (ASL) MRI parameter for vascular and tissue signal distribution - ‘spatial coefficient of variation’ (ASL-sCoV) - correlates better as a radiological marker with atherosclerotic risk than the more courant markers white matter hyperintensity volume (WMHV) and cerebral blood flow (CBF).
Methods
195 participants of the preDIVA trial, aged 72-80 years with systolic hypertension (>140 mmHg) were invited for 2 MRI-scans 2-3 years apart. WMHV was derived from 3D FLAIR; grey matter CBF and ASL-sCoV from ASL. The ASL-sCoV was defined as the standard deviation of CBF divided by the mean CBF in the entire region of interest. Atherosclerotic risk was operationalized as 10-year cardiovascular risk by the Systematic COronary Risk Evaluation Older Persons (SCORE O.P.) and calculated at baseline and follow-up. Data were analysed using linear regression.
Results
CBF was associated with atherosclerotic risk scores at baseline (standardized-beta=-0.26, 95%CI=-0.40,-0.13, p<0.001) but not on follow-up (standardized-beta=-0.14, 95%CI=-0.33,0.04, p=0.12). ASL-sCoV was associated with atherosclerotic risk scores at both time points (baseline standardized-beta=0.23, 95%CI=0.10,0.36, p<0.0001, follow-up standardized beta= 0.20, 95%CI=0.03,0.36, p=0.02). WMHV was not significantly associated with atherosclerotic risk scores at either time-points (p>0.25). There were no longitudinal associations between changes in MRI parameters and baseline atherosclerotic risk scores. Imputation of missing values, exclusion of outliers, and repeating analyses using the Framingham- and ASCVD risk scores instead of the SCORE O.P. gave similar results.
Conclusions
Our findings suggest that ASL-sCoV correlates better with atherosclerotic risk than the more conventional markers CBF and WMHV. Our data reaffirm that non-invasive imaging with MRI is highly informative and could provide additional information about the (cerebro)vascular status, especially in participants in whom early prevention of atherosclerosis and cardiovascular disease might still be attainable.
Involved research facilities
- PET-Center
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NeuroImage Clinical 36(2022)
DOI: 10.1016/j.nicl.2022.103142
Cited 3 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34573
Mitigating pseudoreplication and bias in resource selection functions with autocorrelation-informed weighting
Alston, J.; Fleming, C.; Kays, R.; Streicher, J.; Downs, C.; Ramesh, T.; Reineking, B.; Calabrese, J.
Abstract
Resource selection functions are among the most commonly used statistical tools in both basic and applied animal ecology. They are typically parameterized using animal tracking data, and advances in animal tracking technology have led to increasing levels of autocorrelation between locations in such data sets. Because resource selection functions assume that data are independent and identically distributed, such autocorrelation can cause misleadingly narrow confidence intervals and biased parameter estimates. Data thinning, generalized estimating equations, and step selection functions have been suggested as techniques for mitigating the statistical problems posed by autocorrelation, but these approaches have notable limitations that include statistical inefficiency, unclear or arbitrary targets for adequate levels of statistical independence, constraints in input data, and (in the case of step selection functions) scale-dependent inference. To remedy these problems, we introduce a method for likelihood weighting of animal locations to mitigate the negative consequences of autocorrelation on resource selection functions. This method weights each observed location in an animal's movement track according to its level of autocorrelation, expanding confidence intervals to match an objective target (i.e., the effective sample size for Autocorrelated Gaussian Density Estimation) and accounting for bias that can arise when there are gaps in the movement track. In this study, we describe the mathematical principles underlying our method, demonstrate its practical advantages versus conventional approaches using simulations and empirical data on a water mongoose (\textit{Atilax paludinosus}), a caracal (\textit{Caracal caracal}), and a serval (\textit{Leptailurus serval}), and discuss pathways for further development of our method. We also provide a complete, annotated analytical workflow to help new users apply our method to their own animal tracking data using the \texttt{ctmm R} package.
Keywords: continuous-time movement models; habitat selection; home range; Ornstein-Uhlenbeck process; space use; spatial point process; utilization distribution
Related publications
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Data and code for: Mitigating pseudoreplication and bias in resource selection …
ROBIS: 35259 HZDR-primary research data are used by this (Id 34572) publication -
Data and code for: Mitigating pseudoreplication and bias in resource selection …
RODARE: 1862 HZDR-primary research data are used by this (Id 34572) publication
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Methods in Ecology and Evolution 14(2023)2, 643-654
Online First (2022) DOI: 10.1111/2041-210X.14025
Cited 7 times in Scopus
Downloads
Permalink: https://www.hzdr.de/publications/Publ-34572
alpaka-group/alpaka: alpaka 0.9.0: The SYCL Complex
Bastrakov, S.; Bocci, A.; Di Pilato, A.; Ehrig, S.; Gruber, B. M.; Hübl, A.; Kelling, J.; Pantaleo, F.; Stephan, J.; Vyskocil, J.; Widera, R.; Worpitz, B.
Abstract
The alpaka library is a header-only C++17 abstraction library for accelerator development. Its aim is to provide performance portability across accelerators through the abstraction (not hiding!) of the underlying levels of parallelism.
Keywords: CUDA; HPC; alpaka; OpenMP; HIP; C++; GPU; heterogeneous computing; performance portability; FPGA; SYCL
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Software in external data repository
Publication year 2022
Programming language: C++
System requirements: OS: Linux, Windows, or macOS Software requirements: C++17 compiler, Boost 1.74.0+, CMake 3.18+
License: MPL-2.0 (Link to license text)
Hosted on GitHub: Link to location
DOI: 10.5281/zenodo.6475608
Permalink: https://www.hzdr.de/publications/Publ-34571
Quantifying the impact of cross-border flux on disease dynamics
Abstract
Countries all over the world have implemented various cross-border policies such as mandatory testing, quarantining upon arrival, and travel restrictions to minimize the risk of infection. The strength of these measures has varied over time. The aim of this study is twofold. First, we develop a spatially explicit SIR-type mechanistic model to assess the epidemiological consequences of allowing cross-border mobility between two countries under different epidemic conditions. We show that the time to achieve the peak of infection is significantly changed if cross-border mobility is allowed during disease outbreak. Moreover, if we compare between the scenarios with and without cross-border flux, the difference in peak timings in two countries is reduced in the latter case. Next, based on stochastic simulation, we present a method for estimating cross-border mobility flux between two regions from the difference in peak-timing in infection under some reasonable assumptions. As a case study, we apply the method to data from the Germany-Poland border region and quantify heterogeneity in cross-border fluxes along the border during the COVID-19 pandemic.
Keywords: COVID-19; Infectious disease; Mathematical Modelling; Cross-border mobility; Compartmental modelling
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Lecture (Conference)
Models in Population Dynamics, Ecology and Evolution (MPDEE 2022), 13.-17.06.2022, Torino, Italy
Downloads
Permalink: https://www.hzdr.de/publications/Publ-34569
Differences in the critical dynamics underlying the human and fruit-fly connectome
Ódor, G.; Deco, G.; Kelling, J.
Abstract
Previous simulation studies on human connectomes suggested that critical dynamics emerge subcritically in the so-called Griffiths phases. Now we investigate this on the largest available brain network, the 21662 node fruit-fly connectome, using the Kuramoto synchronization model. As this graph is less heterogeneous, lacking modular structure and exhibiting high topological dimension, we expect a difference from the previous results. Indeed, the synchronization transition is mean-field-like, and the width of the transition region is larger than in random graphs, but much smaller than as for the KKI-18 human connectome. This demonstrates the effect of modular structure and dimension on the dynamics, providing a basis for better understanding the complex critical dynamics of humans.
Keywords: Critical phenomena; Dynamical phase transitions; Neuronal dynamics; Neuronal network activity; Nonequilibrium statistical mechanics; Synchronization transition
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Physical Review Research 4(2022), 023057
DOI: 10.1103/PhysRevResearch.4.023057
Cited 5 times in Scopus -
Contribution to WWW
arXiv:2201.11084 [q-bio.NC]: https://arxiv.org/abs/2201.11084
DOI: 10.48550/arXiv.2201.11084
Permalink: https://www.hzdr.de/publications/Publ-34568
Top-down nanofabrication of silicon nanopillars hosting telecom photon emitters
Jagtap, N. S.; Hollenbach, M.; Fowley, C.; Baratech, J.; Guardia-Arce, V.; Kentsch, U.; Eichler-Volf, A.; Abrosimov, N. V.; Erbe, A.; Shin, C.; Kim, H.; Helm, M.; Lee, W.; Astakhov, G. V.; Berencén, Y.
Abstract
Silicon, a ubiquitous material in modern computing, is an emerging platform for realizing a source of indistinguishable single-photons on demand. The integration of recently discovered single-photon emitters in silicon into photonic structures is advantageous to exploit their full potential for integrated photonic quantum technologies. Here, we show the integration of an ensemble of telecom photon emitters in a two-dimensional array of silicon nanopillars. We developed a top-down nanofabrication method, enabling the production of thousands of individual nanopillars per square millimeter with state-of-the-art photonic-circuit pitch, all the while being free of fabrication-related radiation damage defects. We found a waveguiding effect of the 1278 nm G-center emission along individual pillars accompanied by improved brightness, compared to that of bulk silicon. These results open pathways to monolithically integrating single-photon emitters into a photonic platform.
Involved research facilities
- Radiation Source ELBE DOI: 10.17815/jlsrf-2-58
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 34567) publication
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34567) publication
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Poster
DPG-Tagung 2022, 04.-09.09.2022, Regensburg, Germany
Permalink: https://www.hzdr.de/publications/Publ-34567
A photonic platform hosting telecom photon emitters in silicon
Jagtap, N. S.; Hollenbach, M.; Fowley, C.; Baratech, J.; Guardia-Arce, V.; Kentsch, U.; Eichler-Volf, A.; Abrosimov, N. V.; Erbe, A.; Shin, C.; Kim, H.; Helm, M.; Lee, W.; Astakhov, G. V.; Berencén, Y.
Abstract
Silicon, a ubiquitous material in modern computing, is an emerging platform for realizing a source of indistinguishable single-photons on demand. The integration of recently discovered single-photon emitters in silicon into photonic structures is advantageous to exploit their full potential for integrated photonic quantum technologies [1] [2]. Here, we show the integration of telecom photon emitters in a photonic platform consisting of silicon nanopillars. We developed a CMOS-compatible nanofabrication method, enabling the production of thousands of individual nanopillars per square millimetre with state-of-the-art photonic-circuit pitch, all the while being free of fabrication-related radiation damage defects. We found a waveguiding effect of the 1278 nm G-center emission along individual pillars accompanied by improved brightness, photoluminescence signal-to-noise ratio and photon extraction efficiency compared to that of bulk silicon. These results unlock clear pathways to monolithically integrating single-photon emitters into a photonic platform at a scale that matches the required pitch of quantum photonic circuits.
Keywords: G centers; MACEtch
Involved research facilities
- Radiation Source ELBE DOI: 10.17815/jlsrf-2-58
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34566) publication
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 34566) publication
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Poster
LEAPS meets Quantum Technology, 15.-20.05.2022, Elba Island, Italy
Permalink: https://www.hzdr.de/publications/Publ-34566
Introducing micro physiological systems to evaluate new radiopharmaceuticals: First attempts with radiolabeled cetuximab
Sihver, W.; Nitt-Weber, A.-K.; Behrens, S.; Ullrich, M.; Pietzsch, H.-J.; Namazian Jam, N.; Schmieder, F.; Sonntag, F.
Abstract
Radiopharmaceuticals can be used for targetspecific functional diagnostics, such as PET or SPECT imaging, or radionuclide therapy of diseased tissue, depending on the incorporated radionuclide. Following initial in vitro testing, radiopharmaceutical candidates are usually further characterized in small animals. Since reduction of animal testing is a central precept in preclinical research it would be beneficial to replace at least some of these tests by alternative methods. Using micro-physiological system (MPS) technology, various organ-on-chip models can be created with human cell systems/organoids, which are operated in a circulatory system under defined physiological conditions.
Here we present first attempts to introduce MPS for evaluating radiopharmaceuticals using the radiolabeled anti-EGFR antibody cetuximab (C225) as reference compound.
In an MPS equipped with six 96-well plate-like microwells in a flow chamber, binding of 64Cu and 68Ga-labeled C225 to cells and spheroids grown from A431 (EGFR-positive) and MDA-MB435S (EGFR-negative) cells was measured and compared to conventional microplates. Specific saturation binding of radiolabeled C225 at increasing concentrations was analyzed using a phosphor imaging system.
The affinity of radiolabeled C225 towards A431 spheroids measured in the MPS was in the same range as that of the spheroids in conventional microplates. Within the MPS assays, the results showed a trend towards increased affinity for A431 monolayers compared to the spheroids. The values of binding capacity for radiolabeled C225 on 2D and 3D A431 cell culture models were in the same order of magnitude when measured in MPS or in microplates.
Keywords: radiopharmaceuticals; micro-physiological systems; radiopharmacological parameters; preclinical trials; reduction experimental animals
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Current Directions in Biomedical Engineering 8(2022)2, 532-535
DOI: 10.1515/cdbme-2022-1136
Permalink: https://www.hzdr.de/publications/Publ-34565
Research data: Terahertz-wave decoding of femtosecond extreme-ultraviolet light pulses
Ilyakov, I.; Agarwal, N.; Deinert, J.-C.; Liu, J.; Yaroslavtsev, A.; Foglia, L.; Kurdi, G.; Mincigrucci, R.; Principi, E.; Jakob, G.; Kläui, M.; Seifert, T.; Kampfrath, T.; Kovalev, S.; Carley, R.; Scherz, A.; Gensch, M.
Abstract
This repository entry contains the research data used for generating the publication "Terahertz-wave decoding of femtosecond extreme-ultraviolet light pulses".
Keywords: Terahertz; Extreme Ultraviolet; Pulse-resolved; ultrafast; terahertz tomography; electron bunch diagnostics
Related publications
- DOI: 10.1364/OPTICA.453130 references this (Id 34564) publication
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Terahertz-wave decoding of femtosecond extreme-ultraviolet light pulses
ROBIS: 32547 has used this (Id 34564) publication of HZDR-primary research data
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Reseach data in the HZDR data repository RODARE
Publication date: 2022-04-27 Restricted access
DOI: 10.14278/rodare.1543
Versions: 10.14278/rodare.1544
Downloads
Permalink: https://www.hzdr.de/publications/Publ-34564
Differential evolution optimization of Rutherford back-scattering spectra
Heller, R.; Klingner, N.; Claessens, N.; Merckling, C.; Meersschaut, J.
Abstract
We investigate differential evolution optimization to fit Rutherford back-scattering data. The algorithm helps to find, with very high precision, the sample composition profile that best fits the experimental spectra. The capabilities of the algorithm are first demonstrated with the analysis of synthetic Rutherford back-scattering spectra. The use of synthetic spectra highlights the achievable precision, through which it becomes possible to differentiate between the counting statistical uncertainty of the spectra and the fitting error. Finally, the capability of the algorithm to analyze large sets of experimental spectra is demonstrated with the analysis of the position-dependent composition of a SrxTiyOz layer on a 200 mm silicon wafer. It is shown that the counting statistical uncertainty as well as the fitting error can be determined, and the reported total analysis uncertainty must cover both.
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34563) publication
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Syntetic Spectra Data used in publication "Differential evolution optimization …
ROBIS: 34545 HZDR-primary research data are used by this (Id 34563) publication
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Journal of Applied Physics 132(2022)16, 165302
DOI: 10.1063/5.0096497
Cited 5 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34563
Anion-specific structure and stability of guanidinium-bound DNA origami
Hanke, M.; Dornbusch, D.; Hadlich, C.; Roßberg, A.; Hansen, N.; Grundmeier, G.; Tsushima, S.; Keller, A.; Fahmy, K.
Abstract
While the folding of DNA into rationally designed DNA origami nanostructures has been studied extensively with the aim of increasing structural diversity and introducing functionality, the fundamental physical and chemical properties of these nanostructures remain largely elusive. Here, we investigate the correlation between atomistic, molecular, nanoscopic, and thermodynamic properties of DNA origami triangles. Using guanidinium (Gdm) as a DNA-stabilizing but potentially also denaturing cation, we explore the dependence of DNA origami stability on the identity of the accompanying anions. The statistical analyses of atomic force microscopy (AFM) images and circular dichroism (CD) spectra reveals that sulfate and chloride exert stabilizing and destabilizing effects, respectively, already below the global melting temperature of the DNA origami triangles. We identify structural transitions during thermal denaturation and show that heat capacity changes ΔCp determine the temperature sensitivity of structural damage. The different hydration shells of the anions and their potential to form Gdm+ ion pairs in concentrated salt solutions modulate ΔCp by altered wetting properties of hydrophobic DNA surface regions as shown by molecular dynamics simulations. The underlying structural changes on the molecular scale become amplified by the large number of structurally coupled DNA segments and thereby find a nanoscopic correlation in AFM images.
Keywords: DNA origami; atomic force microscopy; denaturation; circular dichroism; counter ions; heat capacity
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Computational and Structural Biotechnology Journal 20(2022), 2611-2623
DOI: 10.1016/j.csbj.2022.05.037
Cited 9 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34562
A self-consistent planetary synchronization model of short, medium, and long term cycles of the solar dynamo
Stefani, F.; Horstmann, G. M.; Klevs, M.; Stepanov, R.; Weier, T.
Abstract
In a series of recent papers we have developed a self-consistent explanation of short, medium and long term solar cycles in terms of synchronization by planetary motions. According to this model, the surprisingly phase-stable 22.14-year Hale cycle results from parametric resonance of a conventional α−Ω dynamo with an oscillatory part of the helical turbulence parameter α that is thought to be synchronized by the 11.07-year spring-tide periodicity of the three tidally dominant planets Venus, Earth and Jupiter. The medium term Suess-de Vries cycle (specified to 193 years in our model) emerges as a beat period between the basic 22.14-year Hale cycle and some (yet not well
understood) spin–orbit coupling connected with the motion of the Sun around the barycenter of the solar system that is governed by the 19.86-year synodic period of Jupiter and Saturn. Closely related to this, Gleissberg-type cycles appear as nonlinear beat effects and/or from perturbations of the Sun’s orbital motion due to other synodic periods of the Jovian planets. Finally, the long-term variations on the millennial time-scale (Bond events) arise as chaotic transitions between regular and irregular episodes of the solar dynamo, in close analogy with the super-modulation concept introduced by Weiss and Tobias.
Keywords: solar dynamo; synchronization
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Lecture (Conference)
The 12th pamir International Conference on Fundamental and Applied MHD, 04.-08.07.2022, Krakow, Poland
Permalink: https://www.hzdr.de/publications/Publ-34561
Development of a Copper-free Click-Radiolabeling for 99mTc-Tricarbonyl Complexes
Schlesinger, M.
Abstract
Click chemistry, and in particular copper-free click reactions, have gained growing interest in the field of radiopharmaceutical sciences. The 99mTc-tricarbonyl moiety is an excellent precursor for radiolabelling of biomolecules. This master thesis aims at synthesizing two new chelators containing the 2,2’-dipicolylamine (DPA) moiety for 99mTc and investigating the copper-free strain-promoted cycloaddition for the Tc(CO)3-core. The first chelator was based on a tetrafluorophenyl ester and was successfully radiolabeled with [99mTc][Tc(CO)3(H2O)3]+ at 40°C with a a radiochemical conversion (RCC) of 89% after 20 min. The chelator was afforded in a radiochemical purity over 99% after separation using a cartridge. The subsequent conjugation of an amine-functionalized PSMA (prostate-specific membrane antigen) targeting motif was investigated, and the PSMA targeting 99mTc-complex was afforded with an RCC of 23% at 100°C after 150 min. Two other unknown side products were observed. Further in-depth studies are required to optimize the radiolabeling and to identify the formed side-products. For the SPAAC reaction, a 4,8-diazacyclononyne containing the DPA moiety was prepared via the Nicholas reaction. Radiolabeling at 100°C afforded the radiolabeled complex with an RCC of 89% after 30 min. The ensuing SPAAC reaction with an azide-functionalized PSMA motif was studied at three different temperatures. The PSMA targeting 99mTc-complex was afforded selectively at 100°C after 4 hours with an RCC of 89%. No side products were observed. Nonradioactive Re(CO)3-complexes were synthesized and characterized to confirm the 99mTc-complexes. Further modifications of the 4,8-diazacyclononyne could prospectively enable to carry out the radiolabeling under physiological conditions. Continuing in vitro and in vivo experiments are planned.
Keywords: technetium-99m; click reaction; strainpromoted; tricarbonyl complex
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Master thesis
Universität Leipzig, 2022
Mentor: PD Dr. habil. Constantin Mamat
122 Seiten
Permalink: https://www.hzdr.de/publications/Publ-34560
Band-gap and strain engineering in GeSn alloys using post-growth pulsed laser melting
Steuer, O.; Schwarz, D.; Oehme, M.; Schulze, J.; Mączko, H.; Kudrawiec, R.; Fischer, I. A.; Heller, R.; Hübner, R.; Khan, M. M.; Georgiev, Y.; Zhou, S.; Helm, M.; Prucnal, S.
Abstract
Alloying Ge with Sn enables effective band-gap engineering and improves significantly the charge carrier mobility. The pseudomorphic growth of Ge1-xSnx on Ge causes in-plane compressive strain, which degrades the superior properties of the Ge1-xSnx alloys. Therefore, efficient strain engineering is required. In this article, we present strain and band-gap engineering in GeSn alloys grown on Ge a virtual substrate using post-growth nanosecond pulsed laser melting (PLM). Micro-Raman and X-ray diffraction show that the initial in-plane compressive strain is removed. Moreover, for PLM energy densities higher than 0.5 J cm-2, the Ge0.89Sn0.11 layer becomes tensile strained. Simultaneously, as revealed by Rutherford Backscattering spectrometry, cross-sectional transmission electron microscopy investigations and X-ray diffraction the crystalline quality and Sn-distribution in PLM-treated Ge0.89Sn0.11 layers are only slightly affected. Additionally, the change of the band structure after PLM is also confirmed by low-temperature photoreflectance measurements. The presented results prove that post-growth ns-range PLM is an effective way for band-gap and strain engineering in highly-mismatched alloys.
Keywords: Germanium Tin; band-gap engineering; GeSn; pseudomorphic growth; pulsed laser melting; GeSn alloys; molecular-beam epitaxy; Ge1-xSnx
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
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- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34559) publication
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Journal of Physics: Condensed Matter 35(2023)5, 055302
Online First (2022) DOI: 10.1088/1361-648X/aca3ea
Cited 6 times in Scopus -
Lecture (Conference)
Band-gap and strain engineering in GeSn alloys using post-growth pulsed laser melting, 05.-09.09.2022, Regensburg, Deutschland
Permalink: https://www.hzdr.de/publications/Publ-34559
High-field magnetization studies and their analysis in RFe11Ti and RFe11TiH1 rare-earth intermetallics (an example: HoFe11TiHx, x = 0 and 1)
Kostyuchenko, N. V.; Tereshina, I. S.; Tereshina-Chitrova, E. A.; Skoursky, J.; Doerr, M.; Zvezdin, A. K.; Drulis, H.
Abstract
We present experimental high-field magnetization studies for the single-crystalline ferrimagnetic RFeTi compounds at example of holmium-based hydride in order to evaluate, compare and analyze the crystal-field and exchange parameters. We predict theoretically the magnetization behavior of HoFe11Ti up to 80 T magnetic field for the first time. The results are compared with data for the parent compound HoFe11TiH1 and those with erbium and thulium (x = 0 and 1).
Involved research facilities
- High Magnetic Field Laboratory (HLD)
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AIP Advances 12(2022), 035050
DOI: 10.1063/9.0000363
Cited 1 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34558
Fermi surface of a system with strong valence fluctuations: Evidence for a noninteger count of valence electrons in EuIr2Si2
Götze, K.; Bergk, B.; Ignatchik, O.; Polyakov, A.; Kraft, I.; Lorenz, V.; Rosner, H.; Förster, T.; Seiro, S.; Sheikin, I.; Wosnitza, J.; Geibel, C.
Abstract
We present de Haas-van Alphen (dHvA) measurements on an Eu-based valence-fluctuating system. EuIr2Si2 exhibits a temperature-dependent, noninteger europium valence with Eu2.8+ at low temperatures. The comparison of experimental results from our magnetic-torque experiments in fields up to 32 T and density functional theory band-structure calculations with localized 4f electrons shows that the best agreement is reached for a Fermi surface based on a valence of Eu2.8+. The calculated quantum-oscillation frequencies for Eu3+ instead cannot explain all the experimentally observed frequencies. The effective masses, derived from the temperature dependence of the dHvA oscillation amplitudes, show not only a significant enhancement with masses up to 11 me (me being the free electron mass), but also a magnetic-field dependence of the heaviest mass. We attribute the formation of these heavy masses to strong correlation effects resulting from valence fluctuations of 4f electrons being strongly hybridized with conduction electrons. The increase of the heavy masses with magnetic field likely results from the onset of the expected field-induced valence crossover that enhances these valence fluctuations but does not alter the Fermi-surface topology in the field range studied.
Involved research facilities
- High Magnetic Field Laboratory (HLD)
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Physical Review B 105(2022), 155125
DOI: 10.1103/PhysRevB.105.155125
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- Open Access Version from wrap.warwick.ac.uk
- Secondary publication expected
Permalink: https://www.hzdr.de/publications/Publ-34557
Collinear order in the spin-5/2 triangular-lattice antiferromagnet Na3Fe(PO4)2
Sebastian, S. J.; Islam, S. S.; Jain, A.; Yusuf, S. M.; Uhlarz, M.; Nath, R.
Abstract
We set forth the structural and magnetic properties of the frustrated spin-5/2 triangle lattice antiferromagnet Na3Fe(PO4)2 examined via x-ray diffraction, magnetization, heat capacity, and neutron diffraction measurements on the polycrystalline sample. No structural distortion was detected from the temperature-dependent x-ray diffraction down to 12.5 K, except a systematic lattice contraction. The magnetic susceptibility at high temperatures agrees well with the high-temperature series expansion for a spin-5/2 isotropic triangular lattice antiferromagnet with an average exchange coupling of J/kB ≃ 1.8 K rather than a one-dimensional spin-5/2 chain model. This value of the exchange coupling is consistently reproduced by the saturation field of the pulse field magnetization data. It undergoes a magnetic long-range order at TN ≃ 10.4 K. Neutron diffraction experiments elucidate a collinear antiferromagnetic ordering below TN with the propagation vector k = (1, 0, 0). An intermediate value of frustration ratio ( f ≃ 3.6) reflects moderate frustration in the compound which is corroborated by a reduced ordered magnetic moment of ∼1.52μB at 1.6 K, compared to its classical value (5μB). Magnetic isotherms exhibit a change of slope envisaging a field induced spin-flop transition at HSF ≃ 3.2 T. The magnetic field vs temperature phase diagram clearly unfold three distinct phase regimes, reminiscent of a frustrated magnet with in-plane (XY-type) anisotropy.
Involved research facilities
- High Magnetic Field Laboratory (HLD)
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Physical Review B 105(2022), 104425
DOI: 10.1103/PhysRevB.105.104425
Cited 6 times in Scopus
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Permalink: https://www.hzdr.de/publications/Publ-34556
Tunneling transport in WSe2-MoS2 heterojunction transistor enabled by a two-dimensional device architecture
Chava, P.; Watanabe, K.; Taniguchi, T.; Mikolajick, T.; Helm, M.; Erbe, A.
Abstract
Heterojunctions made of two-dimensional (2D) semiconducting materials provide promising properties for the realization of tunnel field effect transistors (TFETs). The absence of dangling bonds allows the formation of sharp hetero-interfaces, which enables the reduction of parasitic components arising due to interface traps. In this work, we demonstrate band-to-band tunneling (BTBT) between layers of WSe2 and MoS2 that are contacted with few-layered graphene (FLG) on both sides of the junction and completely encapsulated with hexagonal boron nitride (h-BN). Additionally, we also use the FLG as a gate electrode, which allows us to realize devices made entirely of different 2D materials. We observe negative differential resistance (NDR) confirming the tunneling transport in our devices showing the potential in terms of further optimization.
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34555) publication
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Contribution to proceedings
Device Research Conference (DRC) 2022, 26.-29.06.2022, Columbus, Ohio, USA
2022 Device Research Conference (DRC), 978-1-6654-9883-8
DOI: 10.1109/DRC55272.2022.9855785
Cited 3 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34555
A combined extended x–ray absorption fine structure spectroscopy and density functional theory study of americium vs. yttrium adsorption on corundum (α–Al2O3)
Huittinen, N. M.; Virtanen, S.; Roßberg, A.; Eibl, M.; Lönnrot, S.; Polly, R.
Abstract
Adsorption reactions on mineral surfaces are influenced by the overall concentration of the adsorbing metal cation. Different site types (strong vs. weak ones) are often included to describe the complexation reactions in the various concentration regimes. More specifically, strong sites are presumed to retain metal ions at low sorbate concentrations, while weak sites contribute to metal ion retention when the sorbate concentration increases. The involvement of different sites in the sorption reaction may, thereby, also be influenced by competing cations, which increase the overall metal ion concentration in the system. To date, very little is known about the complex structures and metal ion speciation in these hypothetical strong- and weak-site regimes, especially in competing scenarios. In the present study, we have investigated the uptake of the actinide americium on corundum (α–Al2O3) in the absence and presence of yttrium as competing metal by combining extended X-ray absorption fine structure spectroscopy (EXAFS) with density functional theory (DFT) calculations. Isotherm studies using the radioactive 152Eu tracer were used to identify the sorption regimes where strong sites and weak sites contribute to the sorption reaction. The overall americium concentration, as well as the presence of yttrium could be seen to influence both the amount of americium uptake by corundum, but also the speciation at the surface. More specifically, increasing the Am3+ or Y3+ concentrations from the strong site to the weak site concentration regimes in the mineral suspensions resulted in a decrease in the overall Am–O coordination number from nine to eight, with a subsequent shortening of the average Am–O bond length. DFT calculations suggest a reduction of the surface coordination with increasing metal–ion loading, postulating the formation of tetradentate and tridentate Am3+ complexes at low and high surface coverages, respectively.
Keywords: EXAFS; DFT; sorption competition; Am3+; Y3+; speciation; strong sites; weak sites
Involved research facilities
- Rossendorf Beamline at ESRF DOI: 10.1107/S1600577520014265
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- DOI: 10.1107/S1600577520014265 is cited by this (Id 34553) publication
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Minerals 12(2022)11, 1380
DOI: 10.3390/min12111380
Permalink: https://www.hzdr.de/publications/Publ-34553
Influence of Albumin Binders on Tumor Uptake of 225Ac-mcp-PSMA-Radioconjugates
Mamat, C.; Reissig, F.; Zarschler, K.; Novy, Z.; Petrik, M.; Bendova, K.; Kurfurstova, D.; Bouchal, J.; Pietzsch, H.-J.; Kopka, K.
Abstract
The prostate-specific membrane antigen (PSMA) is expressed in approx. 80% of prostate cancer at considerably higher levels in tumor cells compared to healthy tissues. Its upregulation occurs in all stages of the disease. Therefore, PSMA has emerged as an attractive target for molecular imaging and especially targeted radionuclide therapy (endoradiotherapy) of metastatic castration-resistant prostate cancer (mCRPC).
Due to its favorable nuclear physical properties, actinium-225 belongs to the clinically applied alpha emitters for therapeutic applications. More than ten clinical trials are displayed for actinium-225-DOTA-based conjugates. A trial using [225Ac]Ac-PSMA-617 as the IMP in men with PSMA-positive prostate cancer is projected to start. Actinium-225 can be chelated with the standard DOTA chelator, but requires rather harsh labeling conditions such as high temperatures (80–95°C) or microwave assistance. Alternatively, with the complexing agent macropa mild labeling conditions, low reaction temperature and high in vivo stability can be realized owing to its perfect characteristics for Ac3+ chelation.
Moreover, to further improve the tumor uptake for future targeted alpha therapy, albumin binding units based on 4-iodophenylbutyrate were introduced to increase the tumor uptake. Two 225Ac-radioconjugates with albumin binders were prepared, either containing one or two PSMA-binding units (based on PSMA-617), the second one to raise the binding affinity to the PSMA receptor. The synthetic approach consisted of the functionalization of one or two picolinic side arms with a clickable reactive site for the connection of the vector molecules. The azide-functionalized PSMA derivative, which also contains the albumin binder, was prepared using standard peptide coupling conditions. Cell culture-based studies regarding radioligand affinity and clonogenicity were performed using PSMA-positive LNCaP cells and the biodistribution of the radioconjugates was evaluated using LNCaP tumor-bearing mice.
Radiolabeling of both PSMA ligands with [225Ac]Ac3+ was performed at up to 5 MBq/nmol with >99% radiochemical purity. Cell binding and survival studies revealed a higher cell binding affinity and an improved cell killing efficiency for the radioconjugate with two PSMA-binding entities compared to the derivative with only one targeting motif. A considerable binding of both radioligands to mouse, rat and human serum proteins was confirmed. Biodistribution studies revealed enhanced blood circulation times of both albumin-binding PSMA ligands compared to their counterparts without the albumin binders. A substantially higher accumulation in LNCaP tumors up to 50 %ID/g (one PSMA-binding moiety) and 120 %ID/g (two PSMA-binding moieties) after 120 h p.i., respectively, was also observed. Additionally, a considerable DNA damage and a massive decrease in cell proliferation was observed by immunohistochemical examination of LNCaP tumors, whereas necrosis in the kidneys of the animals was not observed.
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Lecture (Conference)
TERACHEM 2022, 14.-17.09.2022, Bressanone, Italien
Permalink: https://www.hzdr.de/publications/Publ-34552
Temporal contrast-dependent modeling of laser-driven solids - studying femtosecond-nanometer interactions and probing
Abstract
Establishing precise control over the unique beam parameters of laser-accelerated ions from relativistic ultra-short pulse laser-solid interactions has been a major goal for the past 20 years. While the spatio-temporal coupling of laser-pulse and target parameters create transient phenomena at femtosecond-nanometer scales that are decisive for the acceleration performance, these scales have also largely been inaccessible to experimental observation. Computer simulations of laser-driven plasmas provide valuable insight into the physics at play. Nevertheless, predictive capabilities are still lacking due to the massive computational cost to perform these in 3D at high resolution for extended simulation times. This thesis investigates the optimal acceleration of protons from ultra-thin foils following the interaction with an ultra-short ultra-high intensity laser pulse, including realistic contrast conditions up to a picosecond before the main pulse. Advanced ionization methods implemented into the highly scalable, open-source particle-in-cell code PIConGPU enabled this study. Supporting two experimental campaigns, the new methods led to a deeper understanding of the physics of Laser-Wakefield acceleration and Colloidal Crystal melting, respectively, for they now allowed to explain experimental observations with simulated ionization- and plasma dynamics. Subsequently, explorative 3D3V simulations of enhanced laser-ion acceleration were performed on the Swiss supercomputer Piz Daint. There, the inclusion of realistic laser contrast conditions altered the intra-pulse dynamics of the acceleration process significantly. Contrary to a perfect Gaussian pulse, a better spatio-temporal overlap of the protons with the electron sheath origin allowed for full exploitation of the accelerating potential, leading to higher maximum energies. Adapting well-known analytic models allowed to match the results qualitatively and, in chosen cases, quantitatively. However, despite complex 3D plasma dynamics not being reflected within the 1D models, the upper limit of ion acceleration performance within the TNSA scenario can be predicted remarkably well. Radiation signatures obtained from synthetic diagnostics of electrons, protons, and bremsstrahlung photons show that the target state at maximum laser intensity is encoded, previewing how experiments may gain insight into this previously unobservable time frame.
Furthermore, as X-ray Free Electron Laser facilities have only recently begun to allow observations at femtosecond-nanometer scales, benchmarking the physics models for solid-density plasma simulations is now in reach. Finally, this thesis presents the first start-to-end simulations of optical-pump, X-ray-probe laser-solid interactions with the photon scattering code ParaTAXIS. The associated PIC simulations guided the planning and execution of an LCLS experiment, demonstrating the first observation of solid-density plasma distribution driven by near-relativistic short-pulse laser pulses at femtosecond-nanometer resolution.
Keywords: laser ion acceleration; TNSA; particle-in-cell; PIConGPU; Smilei; temporal laser contrast; SAXS; ParaTAXIS; HPC
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Doctoral thesis
TU Dresden, 2022
Mentor: Thomas Kluge
193 Seiten -
Wissenschaftlich-Technische Berichte / Helmholtz-Zentrum Dresden-Rossendorf; HZDR-124 2023
ISSN: 2191-8708, eISSN: 2191-8716
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Permalink: https://www.hzdr.de/publications/Publ-34551
Membrane-free alkali metal - iodide battery with a molten salt
Lee, J.; Monrrabal Marquez, G.; Sarma, M.; Lappan, T.; Hofstettet, Y. J.; Trtik, P.; Landgraf, S.; Ding, W.; Kumar, S.; Vaynzof, Y.; Weber, N.; Weier, T.
Abstract
Batteries with liquid metal electrodes are attractive candidates for sustainable
energy storage applications due to low manufacturing cost as well as high recyclability. For
broad applications, these batteries should be developed for lower operating temperature,
higher cell voltage, and membrane-free cell configuration. Here, we demonstrate a new type
of membrane-free electrochemical energy storage system relying on liquid alkali metals and
iodide. As a proof-of-concept study, membrane-free alkali metal-iodide (A-AI) batteries were
constructed by a facile cell assembly introducing current collectors, LiI-LiCl-KI-CsI salt mixture, and an insulator without relying on solid-state mediums for separating electrolytes. For the initial assembly, no active electrode materials were required since they can be naturally formed during battery operation. Despite the unoptimized cell construction, the membrane-free A-AI batteries showed promising electrochemical performance such as voltage efficiency of ca. 40 % at 500 mA/cm2, maximum specific energy of 34.2 Wh/kg with an energy efficiency of 59 % for a charging/discharging period of 5.8 h and reliable stability for 250 cycles. Even without ion-selective membranes, we observed a relatively low self-discharge rate of 3.56 mA/cm2, which implies the possibility of an iodine-concentrated layer at the bottom of the cell. This was further supported by post-mortem analyses using neutron radiography.
Additionally, X-ray photoemission spectroscopy was performed to identify the changes in the
iodine concentration in the cell.
Keywords: liquid metal batteries; alkali metal-iodide batteries; liquid metal electrodes; low-temperature molten salt; membrane-free energy storage; neutron radiography
Related publications
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Data publication: Membrane-free alkali metal-iodide battery with a molten salt
ROBIS: 36678 HZDR-primary research data are used by this (Id 34550) publication
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Energy Technology 11(2023)7, 2300051
DOI: 10.1002/ente.202300051
Cited 1 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34550
Top-down fabrication of silicon photonic structures for hosting single-photon emitters
Jagtap, N.; Hollenbach, M.; Fowley, C.; Berencen, Y.; Lee, W.; Astakhov, G.; Erbe, A.; Helm, M.
Abstract
Silicon, the ubiquitous material for computer chips, has recently been shown to be instrumental for hosting sources of single-photons emitting in the strategic optical telecommunication O-band (1260-1360 nm)[1], the so-called G center. To increase the brightness and the photon extraction efficiency of single G center, the coupling of these centers into photonic structures is strong. This work presents a top-down approach avoiding the use of ion beam-based etching methods for fabricating high-quality defect-free photonic structures such as silicon nanopillars, which can host singlephoton emitters. This method builds upon a wet-chemical process known as metal-assisted chemical etching. We report the successful fabrication of two-dimensional arrays of vertically-directed waveguiding silicon nanopillars. We also show the etch chemistry dependence on the Si wafer resistivity along with its effect on the etch rate and the sidewall roughness of pillars for a variety of pillar diameters.
References:[1] M. Hollenbach, et al. Opt. Express 28,26111-26121
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
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- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34549) publication
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Poster (Online presentation)
virtual DPG-Frühjahrstagungen (DPG Spring Meetings) 2021, 27.-30.09.2021, Online, Germany
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Permalink: https://www.hzdr.de/publications/Publ-34549
Top down Fabrication of Silicon Photonic Structures by Metal Assisted Chemical Etching
Jagtap, N.
Abstract
Silicon, the ubiquitous material for computer chips, has recently been shown to be instrumental for hosting sources of single-photons emitting in the strategic optical telecommunication O-band (1260-1360 nm)[1], the so-called G center. To increase the brightness and the photon extraction efficiency of single G center, the coupling of these centers into photonic structures is strong.
This work presents a top-down approach avoiding the use of ion beam-based etching methods for fabricating high-quality defect-free photonic structures such as silicon nanopillars, which can host single photon emitters. This method builds upon a wet-chemical process known as MACEtch. We report the successful fabrication of two-dimensional arrays of vertically directed wave guiding silicon nanopillars. The confocal microscopy after carbon ion implantation shows presence of ensembles of G centers.
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34548) publication
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Lecture (Conference)
NANONET Annual Workshop 2021, 21.-23.09.2021, Klingenberg, Germany
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Permalink: https://www.hzdr.de/publications/Publ-34548
Copper-free Click Labeling with the 99mTc-Tricarbonyl-Core Using DACN Derivatives
Schlesinger, M.; Jentschel, C.; Pietzsch, H.-J.; Kopka, K.; Mamat, C.
Abstract
Diazacyclononyne (DACN) derivatives belong to the class of diazamacrocycles containing a strained alkyne bond. Therefore, DACNs are predestinated starting materials to be applied in copper-free strain-promoted click labeling with azide-functionalized bio(macro)molecules. The diazamacrocyclic scaffold is easy to prepare via a double Nicholas reaction. The following functionalization is convenient by the use of functionalized sulfonamides or by the alkylation of the secondary amines provided by the molecule.
To make the DACN derivatives suitable for radiolabeling with technetium-99m, two dipicolylamine (DPA) derivatives were prepared allowing the use of the 99mTc-tricarbonyl core. The first DPA-ligand is functionalized with an activated ester to allow convenient labeling of, e.g., amines. The second is based on the DACN macrocycle, allowing the copper-free click labeling. Two PSMA-binding derivatives based on PSMA-617 were chosen for final radiolabeling, one with a terminal amine function the other with an azide function.
For the conventional radiolabeling with e.g. primary amines, the DPA chelator was functionalized with a benzoate moiety which was further transferred into the corresponding activated TFP ester using tetrafluorophenol in three steps and an overall yield of 64%. For the click labeling procedure, the functionalized DACN macrocycle was prepared from a sulfonyl-modified diamide (4 steps) which was reacted with butyne-1,3-diol under Nicholas conditions. Finally, the DPA moiety was connected to the DACN via the propylsulfonyl linker. Both derivatives were reacted with (Et4N)2[ReBr3(CO)3] in methanol to obtain both reference complexes (natRe-DPA-TFP ester: 91% yield, natRe-DPA-DACN: 76% yield).
[99mTc][Tc(CO)3]+ was prepared according to an established protocol using 99mTc-pertechnetate and K2[H3BCO2] (in-house-produced tricarbonyl kit). Prior to its use, the solution was brought to pH 5.5 using MES buffer. The radiolabeling of the DPA-TFP derivative was accomplished with [99mTc][Tc(CO)3]+ at 40°C for 30 min in MES buffer (pH 5.5) obtaining the 99mTc-DPA-TFP ester with a radiochemical yield of 89%. The DPA-DACN derivative was labeled under the same conditions yielding 99mTc-DPA-DACN with 83% RCY. The connection of the 99mTc-labeled TFP ester to the primary amine of the PSMA targeting derivative was realized with 23% RCY at 100°C after 2.5 hours. Two additional by-products were observed by radio-HPLC indicating hydrolysis of the 99mTc-DPA-TFP ester. In contrast, by-products were not found using the click reaction of the 99mTc-labelled DPA-DACN-derivative for the conjugation with the azide-functionalized PSMA derivative. The labeling was performed using the same conditions, leading to 79% RCY after 4 hours. Both 99mTc-radiolabeled DPA-building blocks and both 99mTc-PSMA targeting derivatives were evidenced by comparison of the retention times of their respective natRe-derivatives.
Keywords: technetium-99m; click; tricarbonyl
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Poster
TERACHEM 2022, 14.-17.09.2022, Bressanone, Italien
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Biohydrometallurgy in e-waste recycling
Abstract
E-waste recycling starts to focus more on biological methods that are developed in only a few institutes. The Biotechnology devision at Helmholtz Institute Freiberg for Resource Technology focusses on three main research approaches called bioflotation, biosorption and bioleaching. All these techniques and examples out of litereature and the lab are shown in this lecture.
Keywords: biomolecules; bacteria; e-waste; siderophores; peptides
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Invited lecture (Conferences)
(Online presentation)
Urban mining lectures, 25.3.2022, Vancouver, Canada
Permalink: https://www.hzdr.de/publications/Publ-34546
Syntetic Spectra Data used in publication "Differential evolution optimization of Rutherford back-scattering spectra"
Heller, R.; Meersschaut, J.; Claessens, N.; Merckling, C.; Klingner, N.
Abstract
The zip-file contains all synthetic spectra as used for and described in the publication "Differential evolution optimization of Rutherford back-scattering spectra" and all simulation input files for the code RUTHELDE presented therein. Naming according to the text in the paper. All files are in human readable ASCII format. The simulation input files can be best viewed with any kind of JSON file editor.
Related publications
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Differential evolution optimization of Rutherford back-scattering spectra
ROBIS: 34563 has used this (Id 34545) publication of HZDR-primary research data
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Reseach data in the HZDR data repository RODARE
Publication date: 2022-04-14 Open access
DOI: 10.14278/rodare.1541
Versions: 10.14278/rodare.1542
License: CC-BY-4.0
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Enhanced blood retention and tumor uptake of PSMA-targeting, 225Ac-labeled radioconjugates
Reissig, F.; Zarschler, K.; Ludik, M.-C.; Novy, Z.; Petrik, M.; Bendova, K.; Kurfürstova, D.; Bouchal, J.; Pietzsch, H.-J.; Kopka, K.; Mamat, C.
Abstract
Objectives
The prostate-specific membrane antigen (PSMA) is expressed in most cases of prostate cancer at considerably higher levels in tumor cells compared to healthy tissues [1-3] and its upregulation occurs in all stage of the disease [4, 5]. Therefore, PSMA has emerged as an attractive target for molecular imaging and especially targeted radionuclide therapy (endoradiotherapy) of metastatic castration-resistant prostate cancer (mCRPC), given the example of [177Lu]Lu-PSMA-617. We recently described the synthesis and in-depth characterization of PSMA radioligands for targeted alpha therapy with actinium-225 [6]. Our present study aimed at the design, synthesis and preclinical evaluation of albumin-binding PSMA ligands in order to optimize their tissue distribution profile and to improve their pharmacokinetic properties.
Methods
Two novel compounds were prepared by combining a macropa chelator with one or two lysine-ureido-glutamate–based PSMA-binding entities equipped with 4-(p-iodophenyl)butyrate residues. The albumin-binding properties of the 225Ac-labeled conjugates were investigated in vitro using mouse, rat and human serum. The specific interaction of both compounds with human serum albumin was confirmed by microscale thermophoresis. Cell culture-based studies regarding radioligand affinity and clonogenicity were performed on PSMA-positive LNCaP cells. The biodistribution of the radioconjugates was analyzed in LNCaP tumor-bearing mice with ensuing investigation of tissue toxicity by histological examinations.
Results
Radiolabeling of both PSMA ligands with 225Ac was achieved at up to 5 MBq/nmol with >99% radiochemical purity. In vitro assays confirmed considerable binding of the radioligands to mouse, rat and human serum proteins. Cell binding and survival studies revealed a higher cell binding affinity and an improved cell killing efficiency for the radioconjugate with two PSMA-binding entities compared to the derivative with only one targeting motif. Biodistribution studies revealed enhanced blood circulation times of the new albumin-binding PSMA ligands compared to their counterparts lacking the 4-(p-iodophenyl)butyrate residues as well as substantially higher accumulation in LNCaP tumors up to 50 %ID/g (one PSMA-binding moiety) and 150 %ID/g (two PSMA-binding moieties), respectively, after 120 h p.i. Considerable DNA damage and a massive decrease in cell proliferation was observed by histological examination of LNCaP tumors, whereas necrosis in the kidneys of the animals was not detected.
Conclusions
In this study, we demonstrate the development and evaluation of two new PSMA-targeting radioligands comprising 4-(p-iodophenyl)butyrate residues as albumin binder. The prolonged blood circulation of the novel radioligands resulted in greatly enhanced tumor uptake and retention over time. These radioconjugates have the potential to improve the efficacy of targeted alpha therapy and are promising candidates for the treatment of mCRPC.
Keywords: targeted alpha therapy; actinium-225; albumin binder
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Lecture (Conference)
24th International Symposium on Radiopharmaceutical Sciences, 29.05.-02.06.2022, Nantes, Frankreich -
Abstract in refereed journal
Nuclear Medicine and Biology 108-109(2022), S30-S31
DOI: 10.1016/S0969-8051(22)00103-2
Permalink: https://www.hzdr.de/publications/Publ-34544
Multi-Center Magnon Excitations Open the Entire Brillouin Zone to Terahertz Magnetometry of Quantum Magnets
Biesner, T.; Roh, S.; Razpopov, A.; Willwater, J.; Süllow, S.; Li, Y.; Zoch, K. M.; Medarde, M.; Nuss, J.; Gorbunov, D.; Scurschii, I.; Pustogow, A.; Brown, S. E.; Krellner, C.; Valenti, R.; Puphal, P.; Dressel, M.
Abstract
Due to the small photon momentum, optical spectroscopy commonly probes magnetic excitations only at the center of the Brillouin zone; however, there are ways to override this restriction. In case of the distorted kagome quantum magnet Y-kapellasite, Y3Cu9(OH)19Cl8, under scrutiny here, the spin (magnon) density of states (SDOS) can be accessed over the entire Brillouin zone through three-center magnon excitations. This mechanism is aided by the three different magnetic sublattices and strong short-range correlations in the distorted kagome lattice. The results of THz time-domain experiments agree remarkably well with linear spin-wave theory (LSWT). Relaxing the conventional zone-center constraint of photons gives a new aspect to probe magnetism in matter.
Involved research facilities
- High Magnetic Field Laboratory (HLD)
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Advanced Quantum Technologies 5(2022)6, 2200023
DOI: 10.1002/qute.202200023
Cited 2 times in Scopus
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Commensurate helicoidal order in the triangular layered magnet Na2MnTeO6
Kurbakov, A. I.; Susloparova, A. E.; Pomjakushin, V. Y.; Skourski, Y.; Vavilova, E. L.; Vasilchikova, T. M.; Raganyan, G. V.; Vasiliev, A. N.
Abstract
The trigonal layered quaternary tellurate Na2MnTeO6 has been studied by means of various techniques to clarify its magnetic properties. The crystal structure of this compound is based on the triangular arrangement of all cations in the parallel layers with the space group P31c. By using symmetry analysis of the magnetic neutron scattering data, we have found that the solution for the magnetic structure corresponds to the magnetic Shubnikov group R3´c´ (No. 167.4.1337). Mn4+ ions in an octahedral environment form a triangular network where all spins are directed from the center of each triangle. Overall magnetic structure in Na2MnTeO6 is commensurate 120° spin helix with propagation vector k = (1/3, 1/3, 1/3) in variance with planar spin structure in structurally equivalent Li2MnTeO6 with magnetic propagation vector k = (1/3, 1/3, 0). The magnetization measurements show that Na2MnTeO6 experiences an antiferromagnetic order at TN = 5.5 K. NMR, electron spin resonance, and thermodynamics experiments demonstrate the extended temperature region of 2D short-range correlations well above the ordering temperature.
Involved research facilities
- High Magnetic Field Laboratory (HLD)
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Physical Review B 105(2022), 064416
DOI: 10.1103/PhysRevB.105.064416
Cited 9 times in Scopus
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Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS
Günther, R.; Pal, A.; Williams, C.; Zimyanin, V. L.; Liehr, M.; von Neubeck, C.; Krause, M.; Parab, M. G.; Petri, S.; Kalmbach, N.; Marklund, S. L.; Sterneckert, J.; Munch Andersen, P.; Wegner, F.; Gilthorpe, J. D.; Hermann, A.
Abstract
Little is known about the early pathogenic events by which mutant superoxide dismutase 1 (SOD1) causes amyotrophic lateral sclerosis (ALS). This lack of mechanistic understanding is a major barrier to the development and evaluation of efficient therapies. Although protein aggregation is known to be involved, it is not understood how mutant SOD1 causes degeneration of motoneurons (MNs). Previous research has relied heavily on the overexpression of mutant SOD1, but the clinical relevance of SOD1 overexpression models remains questionable. We used a human induced pluripotent stem cell (iPSC) model of spinal MNs and three different endogenous ALS-associated SOD1 mutations (D90Ahom, R115Ghet or A4Vhet) to investigate early cellular disturbances in MNs. Although enhanced misfolding and aggregation of SOD1 was induced by proteasome inhibition, Cells 2022, it was not affected by activation of the stress granule pathway. Interestingly, we identified loss of mitochondrial, but not lysosomal, integrity as the earliest common pathological phenotype, which preceded elevated levels of insoluble, aggregated SOD1. A super-elongated mitochondrial morphology with impaired inner mitochondrial membrane potential was a unifying feature in mutant SOD1 iPSC-derived MNs. Impaired mitochondrial integrity was most prominent in mutant D90Ahom MNs, whereas both soluble disordered and detergent-resistant misfolded SOD1 was more prominent in R115Ghet and A4Vhet mutant lines. Taking advantage of patient-specific models of SOD1-ALS in vitro, our data suggest that mitochondrial dysfunction is one of the first crucial steps in the pathogenic cascade that leads to SOD1-ALS and also highlights the need for individualized medical approaches for SOD1-ALS.
Involved research facilities
- High Magnetic Field Laboratory (HLD)
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Cells 11(2022), 1246
DOI: 10.3390/cells11071246
Cited 13 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34541
Hot Hydride Superconductivity Above 550 K
Grockowiak, A. D.; Ahart, M.; Helm, T.; Coniglio, W. A.; Kumar, R.; Glazyrin, K.; Garbarino, G.; Meng, Y.; Oliff, M.; Williams, V.; Ashcroft, N. W.; Hemley, R. J.; Somayazulu, M.; Tozer, S. W.
Abstract
The search for room temperature superconductivity has accelerated in the last few years driven by experimentally accessible theoretical predictions that indicated alloying dense hydrogen with other elements could produce conventional superconductivity at high temperatures and pressures. These predictions helped inform the synthesis of simple binary hydrides that culminated in the discovery of the superhydride LaH10 with a superconducting transition temperature Tc of 260 K at 180 GPa. We have now successfully synthesized a metallic La-based superhydride with an initial Tc of 294 K. When subjected to subsequent thermal excursions that promoted a chemical reaction to a higher order system, the Tc onset was driven irreversibly to 556 K. X-ray characterization confirmed the formation of a distorted LaH10 based backbone that suggests the formation of ternary or quaternary compounds with substitution at the La and/or H sites. The results provide evidence for hot superconductivity, aligning with recent predictions for higher order hydrides under pressure.
Involved research facilities
- High Magnetic Field Laboratory (HLD)
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Frontiers in Electronic Materials 2(2022), 837651
DOI: 10.3389/femat.2022.837651
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Data to "Application of a fluorescence anisotropy-based assay to quantify transglutaminase 2 activity in cell lysates"
Hauser, S.; Sommerfeld, P.; Wodtke, J.; Hauser, C.; Schlitterlau, P.; Pietzsch, J.; Löser, R.; Pietsch, M.; Wodtke, R.
Abstract
Primärdaten zum FA-Assay, activity-based ELISA und ELISA
Keywords: activity-based protein profiling; cancer; ELISA; enzyme assay; transamidase activity
Related publications
- DOI: 10.3390/ijms23094475 references this (Id 34539) publication
-
Application of a fluorescence anisotropy-based assay to quantify …
ROBIS: 34410 has used this (Id 34539) publication of HZDR-primary research data
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Reseach data in the HZDR data repository RODARE
Publication date: 2022-04-13 Closed access
DOI: 10.14278/rodare.1537
Versions: 10.14278/rodare.1538
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Data Publication: Tuning of Curie temperature in Mn5Ge3 films
Xie, Y.; Birowska, M.; Funk, S. H.; Fischer, A. I.; Schwarz, D.; Schulze, J.; Zeng, Y.-J.; Helm, M.; Zhou, S.; Prucnal, S.
Abstract
This contains a set of data that were used to generate the figures and results in the manuscripts: Tuning of Curie temperature in Mn5Ge3 films (DOI: 10.1063/5.0066717).
The compressed folders “Curie temperature in Mn5Ge3 films ” contain below data:
- RBS data
- MH data
- ZFC/FC data
- XRD data
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34538) publication
- DOI: 10.1063/5.0066717 references this (Id 34538) publication
-
Tuning of Curie temperature in Mn5Ge3 films
ROBIS: 34461 has used this (Id 34538) publication of HZDR-primary research data
-
Reseach data in the HZDR data repository RODARE
Publication date: 2022-04-13 Restricted access
DOI: 10.14278/rodare.1535
Versions: 10.14278/rodare.1536
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Localization and chemical speciation of europium(III) in Brassica napus plants
Jessat, J.; John, W.; Moll, H.; Vogel, M.; Steudtner, R.; Drobot, B.; Hübner, R.; Stumpf, T.; Sachs, S.
Abstract
For the reliable safety assessment of repositories of highly radioactive waste, further development of the modelling of radionuclide migration and transfer in the environment is necessary, which requires a deeper process understanding at the molecular level. Eu(III) is a non-radioactive analogue for trivalent actinides, which contribute heavily to radiotoxicity in a repository. For in-depth study of the interaction of plants with trivalent f elements, we investigated the uptake, speciation, and localization of Eu(III) in Brassica napus plants at two concentrations, 30 and 200 µM, as a function of the incubation time up to 72 h. Eu(III) was used as luminescence probe for combined microscopy and chemical speciation analyses of it in Brassica napus plants. The localization of bioassociated Eu(III) in plant parts was explored by spatially resolved chemical microscopy. Three Eu(III) species were identified in the root tissue. Moreover, different luminescence spectroscopic techniques were applied for an improved Eu(III) species determination in solution. In addition, transmission electron microscopy combined with energy-dispersive X-ray spectroscopy was used to localize Eu(III) in the plant tissue, showing Eu-containing aggregates. By using this multi-method setup, a profound knowledge on the behavior of Eu(III) within plants and changes in its speciation could be obtained, showing that different Eu(III) species occur simultaneously within the root tissue and in solution.
Keywords: lanthanides; plants; laser spectroscopy; speciation; chemical microscopy; localization
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Ecotoxicology and Environmental Safety 254(2023), 114741
DOI: 10.1016/j.ecoenv.2023.114741
Cited 2 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34537
10Be at iThemba LABS using a silicon nitride membrane stack as absorber for isobar suppression
Winkler, S.; Mbele, V.; Khosa, R.; Corbett, L.; Bierman, P.; Hidy, A.; Brown, T.; Makhubela, T.; Kramers, J.; Tooth, S.
Abstract
10Be is an important isotope for accelerator mass spectrometry (AMS) because of the demand for cosmogenic radionuclide dating methods in the earth science and paleo-sciences community. At the iThemba Laboratory for Accelerator Based Science (iThemba LABS) we implemented full suppression of the interfering isobar 10B using a silicon nitride foil-stack, utilizing the 2+ charge state for high efficiency. We demonstrate the performance of this newly established AMS system using standards and test samples. We further present the results of an inter-comparison between iThemba LABS and the Center for Accelerator Mass Spectrometry/Lawrence Livermore National Laboratory, on AMS samples prepared from purified quartz at the University of Vermont. The results for 10Be from the laboratories are in close agreement, fully consistent with cross-calibration between them. AMS results for 26Al are in similarly good agreement, demonstrating the performance and accuracy of iThemba LABS for the most commonly measured in situ produced cosmogenic nuclides.
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Nuclear Instruments and Methods in Physics Research B 540(2023), 102-109
DOI: 10.1016/j.nimb.2023.03.024
Permalink: https://www.hzdr.de/publications/Publ-34536
Towards perfectly linearly polarized x-rays
Schulze, K. S.; Grabiger, B.; Loetzsch, R.; Marx-Glowna, B.; Schmitt, A. T.; Laso García, A.; Hippler, W.; Huang, L.; Karbstein, F.; Konôpková, Z.; Schlenvoigt, H.-P.; Schwinkendorf, J.-P.; Strohm, C.; Toncian, T.; Uschmann, I.; Wille, H.-C.; Zastrau, U.; Röhlsberger, R.; Stöhlker, T.; Cowan, T.; Paulus, G. G.
Abstract
In recent years, high-precision x-ray polarimeters have become a key method for the investigation of fundamental physical questions from solid-state physics to quantum optics. Here, we report on the verification of a polarization purity of better than 8×10−11 at an x-ray free-electron laser, which implies a suppression of the incoming photons to the noise level in the crossed polarizer setting. This purity provides exceptional sensitivity to tiny polarization changes and offers intriguing perspectives for fundamental tests of quantum electrodynamics.
Involved research facilities
- HIBEF
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Physical Review Research 4(2022), 013220
DOI: 10.1103/PhysRevResearch.4.013220
Cited 8 times in Scopus
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Peptidoglycan as major binding motif for Uranium bioassociation on Magnetospirillum magneticum AMB-1 in contaminated waters
Krawczyk-Bärsch, E.; Ramtke, J.; Drobot, B.; Müller, K.; Steudtner, R.; Kluge, S.; Hübner, R.; Raff, J.
Abstract
The mining and industrial use of heavy metals lead to locally high heavy metal contamination with serious consequences for the environment and local population. The high potential of biological remediation processes, in particular, the use of magnetotactic bacteria of heavy metal and radionuclide-contaminated waters has recently been discussed. Yet, the molecular reactions involved in the uptake of radionuclides, especially U, by these bacteria are unknown. The present work is a multidisciplinary approach combining wet chemistry, microscopy, and spectroscopy methods. Our findings suggest that the cell wall plays a prominent role in the bioassociation of U(VI). In time-dependent bioassociation studies, up to 95 % of the initial U(VI) was removed from the suspension within the first hours by Magnetospirillum magneticum AMB-1. PARAFAC analysis of TRLFS data highlights that peptidoglycan is the most important ligand involved, showing a stable immobilization of U(VI) over a wide pH range with the formation of three characteristic species. In addition, in-situ ATR FT-IR reveals the predominant binding to carboxylic functionalities, at higher pH polynuclear species seem to play an important role. This comprehensive molecular study may initiate in future new remediation strategies on effective immobilization of U in combination with the bacteria´s magnetic properties.
Keywords: Magnetotactic bacteria; Uranium; Spectroscopy; Microscopy; Bioremediation
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Journal of Hazardous Materials 437(2022), 129376
DOI: 10.1016/j.jhazmat.2022.129376
Cited 3 times in Scopus
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- Final Draft PDF 219 kB Secondary publication
Permalink: https://www.hzdr.de/publications/Publ-34534
Convolutional neural networks predict the linear energy transfer for proton-beam radiotherapy of patients with brain tumours
Starke, S.; Eulitz, J.; Zwanenburg, A.; Troost, E. G. C.; Krause, M.; Lühr, A.; Löck, S.
Abstract
Proton therapy is a promising option for cancer treatment, even though its radiobiological properties are not yet fully considered in clinical practice. In this context, the relative biological effectiveness (RBE) of protons is the most important quantity, which is strongly related to their linear energy transfer (LET). LET distributions can be provided by commercial treatment-planning systems based on Monte Carlo simulations. However, such systems require a considerable amount of computational resources, are not yet available in every proton-therapy centre and may not be applicable to assess retrospective patient data. Here, we provide proof-of-concept for inferring LET distributions using convolutional neural networks (CNN) based on proton therapy radiation dose distributions and treatment-planning computed tomography (CT). We further evaluate established models for estimating treatment-related side effects after proton therapy of brain tumours and observe good agreement between CNN and MC based outputs.
Keywords: proton therapy; linear energy transfer; relative biological effectiveness; convolutional neural networks
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Lecture (Conference)
MIDL 2022 - Medical Imaging with Deep Learning, 06.-08.07.2022, Zürich, Schweiz
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The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation
de Roeck, L.; van der Weide, H.; Eekers, D.; Kramer, M.; Alapetite, C.; Bromstrand, M.; Burnet, N.; Calugaru, V.; Coremans, I.; Di Perri, D.; Harrabi, S.; Innalfi, A.; Klaver, Y.; Langendijk, J.; Méndez Romero, A.; Paulsen, F.; Roelofs, E.; de Ruysscher, D.; Timmermann, B.; Vitek, P.; Weber, D.; Whitfield, G.; Witt Nyström, P.; Zindler, J.; Troost, E. G. C.; Lambrecht, M.
Abstract
Purpose: Treatment-related toxicity after irradiation of brain tumours has been underreported in the lit-
erature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim
of this European Particle Network (EPTN) collaborative project is to develop recommendations for uni-
form follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy.
Methods: A Delphi method-based consensus was reached among 24 international radiation-oncology
experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time
points.
Results: In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using
multiple levels of recommendation. Level I includes all recommendations that are considered minimum
of care, whereas level II and III are optional evaluations in the advanced clinical or research setting,
respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed.
Where relevant, the organ at risk threshold doses for recommended referral to specific organ specialists
are defined.
Keywords: European Particle Therapy Network; Particle therapy; Follow-up; Toxicity; Brain tumour; Skull base tumour; Central nervous system
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Radiotherapy and Oncology 168(2022), 241-249
DOI: 10.1016/j.radonc.2022.01.018
Cited 16 times in Scopus
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Subjective memory impairment in glioma patients with curative radiotherapy
Donix, M.; Seidlitz, A.; Buthut, M.; Löck, S.; Meissner, G.; Matthes, C.; Troost, E. G. C.; Baumann, M.; Raschke, F.; Linn, J.; Krause, M.
Abstract
Background: Radiotherapy in patients with primary brain tumors may affect hippocampal structure and
cause dyscognitive side-effects.
Patients and methods: Using structural MRI and comprehensive neurocognitive evaluation, we investi-
gated associations between hippocampal structure and memory deficits in 15 patients with WHO grade
3 and grade 4 gliomas receiving standard radio(chemo)therapy.
Results: We did not find changes in hippocampal thickness or cognitive abilities three months after com-
pleting radiotherapy. However, subjective memory impairment was associated with symptoms of
depression, but not with objective memory performance, cortical thickness of the hippocampus or radi-
ation dose.
Conclusions: Irrespective of whether there is a bidirectional relationship between affective changes and
subjective cognitive dysfunction in these patients, depressive symptoms remain a target for intervention
to improve their quality of life. The results of our pilot study highlight that future assessment of side
effects of radiotherapy concerning memory should include assessments of depressive symptoms.
Keywords: radiotherapy; hippocampus; MRI; neurocognitive evaluation; subjective memory impairment
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Radiotherapy and Oncology 171(2022), 101-106
DOI: 10.1016/j.radonc.2022.04.010
Cited 1 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34531
Development and functional characterization of a versatile radio-/immunotheranostic tool for prostate cancer management
Arndt, C.; Bergmann, R.; Striese, F.; Merkel, K.; Máthé, D.; Loureiro, L. R.; Mitwasi, N.; Kegler, A.; Fasslrinner, F.; González Soto, K. E.; Neuber, C.; Berndt, N.; Kovács, N.; Szöllősi, D.; Hegedűs, N.; Tóth, G.; Emmermann, J.-P.; Harikumar, K. B.; Kovacs, T.; Bachmann, M.; Feldmann, A.
Abstract
Due to its overexpression on the surface of prostate cancer (PCa) cells, the prostate stem cell antigen (PSCA) is a potential target for PCa diagnosis and therapy. Here we describe the development and functional characterization of a novel IgG4-based anti-PSCA antibody (Ab) derivative (anti-PSCA IgG4-TM) that is conjugated with the chelator DOTAGA. The anti-PSCA IgG4-TM represents a multimodal immunotheranostic compound that can be used (i) as target module (TM) for UniCAR T cell-based immunotherapy, (ii) for diagnostic PET imaging, and (iii) targeted alpha therapy. Cross-linkage of UniCAR T cells and PSCA-positive tumor cells via the anti-PSCA IgG4-TM results in efficient tumor cell lysis both in vitro and in vivo. After radiolabeling with 64Cu2+ the anti-PSCA IgG4-TM was successfully applied for high contrast PET imaging. In a PCa mouse model, it showed specific accumulation in PSCA-expressing tumors, while no uptake in other organs was observed. Additionally, the DOTAGA-conjugated anti-PSCA IgG4-TM was radiolabeled with 225Ac3+ and applied for targeted alpha therapy. A single injection of the 225Ac-labeled anti-PSCA IgG4-TM was able to significantly control tumor growth in experimental mice. Overall, the novel anti-PSCA IgG4-TM represents an attractive first member of a novel group of radio-/immunotheranostics that allows diagnostic imaging, endoradiotherapy, and CAR T cell immunotherapy.
Keywords: prostate cancer; PSCA; PSMA; IgG4; CAR T cell; theranostics; Ac-225; Cu-64; (18)F-JK-PSMA-7
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Cancers 14(2022)8, 1996
DOI: 10.3390/cancers14081996
Cited 9 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34530
Mu2e-II: Muon to electron conversion with PIP-II Contributed paper for Snowmass
Byrum, K.; Corrodi, S.; Oksuzian, Y.; Winter, P.; Xia, L.; Edmonds, A. W. J.; Miller, J. P.; Mott, J.; Marciano, W. J.; Szafron, R.; Bonventre, R.; Brown, D. N.; Kolomensky, Y. G.; Ning, O.; Singh, V.; Prebys, E.; Borrel, L.; Echenard, B.; Hitlin, D. G.; Hu, C.; Lin, D. X.; Middleton, S.; Porter, F. C.; Zhang, L.; Zhu, R.-Y.; Ambrose, D.; Badgley, K.; Bernstein, R. H.; Boi, S.; Casey, B. C. K.; Culbertson, R.; Gaponenko, A.; Glass, H. D.; Glenzinski, D.; Goodenough, L.; Hocker, A.; Kargiantoulakis, M.; Kashikhin, V.; Kiburg, B.; Kutschke, R. K.; Murat, P. A.; Neuffer, D.; Pronskikh, V. S.; Pushka, D.; Rakness, G.; Strauss, T.; Yucel, M.; Bloise, C.; Diociaiuti, E.; Giovannella, S.; Happacher, F.; Miscetti, S.; Sarra, I.; Martini, M.; Ferrari, A.; Müller, S.; Rachamin, R.; Barlas-Yucel, E.; Artikov, A.; Atanov, N.; Davydov, Y. I.; Glagolev, V.; Vasilyev, I. I.; Brown, D. N.; Uesaka, Y.; Denisov, S. P.; Evdokimov, V.; Kozelov, A. V.; Popov, A. V.; Vasilyev, I. A.; Tassielli, G.; Teubner, T.; Chislett, R. T.; Hesketh, G. G.; Lancaster, M.; Campbell, M.; Ciampa, K.; Heller, K.; Messerly, B.; Cummings, M. A. C.; Calibbi, L.; Blazey, G. C.; Syphers, M. J.; Zutshi, V.; Kampa, C.; Mackenzie, M.; Di Falco, S.; Donati, S.; Gioiosa, A.; Giusti, V.; Morescalchi, L.; Pasciuto, D.; Pedreschi, E.; Spinella, F.; Hedges, M. T.; Jones, M.; You, Z. Y.; Zanetti, A. M.; Valetov, E. V.; Dukes, E. C.; Ehrlich, R.; Group, R. C.; Heeck, J.; Hung, P. Q.; Demers, S. M.; Pezzullo, G.; Lynch, K. R.; Popp, J. L.
Abstract
An observation of Charged Lepton Flavor Violation (CLFV) would be unambiguous evidence for
physics beyond the Standard Model. The Mu2e and COMET experiments, under construction, are
designed to push the sensitivity to CLFV in the μ → e conversion process to unprecedented levels.
Whether conversion is observed or not, there is a strong case to be made for further improving
sensitivity, or for examining the process on additional target materials. Mu2e-II is a proposed
upgrade to Mu2e, with at least an additional order of magnitude in sensitivity to the conversion
rate over Mu2e. The approach and challenges for this proposal are summarized. Mu2e-II may be
regarded as the next logical step in a continued high-intensity muon program at FNAL
Keywords: CLFV; MU2E; FNAL; Snowmass
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Contribution to WWW
arXiv:2203.07569 [hep-ex]: https://arxiv.org/abs/2203.07569
DOI: 10.48550/arXiv.2203.07569
Permalink: https://www.hzdr.de/publications/Publ-34527
Data publication: Epitaxial lateral overgrowth of tin spheres driven and directly observed by helium ion microscopy
Klingner, N.; Heinig, K.-H.; Tucholski, D.; Möller, W.; Hübner, R.; Bischoff, L.; Hlawacek, G.; Facsko, S.
Abstract
Raw data for the publication: "Epitaxial lateral overgrowth of tin spheres driven and directly observed by helium ion microscopy". It contains helium ion microscopy, transmission electron microscopy, scanning electron microscopy as well as gallium focused ion microscopy images and XPS data. It shows how the irradiation of tin spheres with keV He ions causes epitaxial lateral overgrowth.
Keywords: helium ion microscope; tin whisker growth; defect kinetics
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34526) publication
- DOI: 10.1021/acs.jpcc.2c03707 references this (Id 34526) publication
-
Epitaxial lateral overgrowth of tin spheres driven and directly observed by …
ROBIS: 34525 has used this (Id 34526) publication of HZDR-primary research data
-
Reseach data in the HZDR data repository RODARE
Publication date: 2022-04-14 Open access
DOI: 10.14278/rodare.1539
Versions: 10.14278/rodare.1540
License: CC-BY-4.0
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Epitaxial lateral overgrowth of tin spheres driven and directly observed by helium ion microscopy
Klingner, N.; Heinig, K.-H.; Tucholski, D.; Möller, W.; Hübner, R.; Bischoff, L.; Hlawacek, G.; Facsko, S.
Abstract
Enhanced interstitial diffusion in tin is a phenomenon often observed during ion-beam irradiation and in lead-free solders. For the latter, this
not very well understood, strain-driven mechanism results in the growth of whiskers, which can lead to unwanted shorts in electronic designs. In ion-beam physics, this phenomenon is often observed as a result of the enhanced formation of Frenkel pairs in the energetic collision cascade. Here, we show how epitaxial growth of tin extrusions on tin-oxide-covered tin spheres can be induced and simultaneously observed by implanting helium using a helium ion microscope. Calculations of collision cascades based on the binary collision approximation and 3D-lattice-kinetic Monte Carlo simulations show that the implanted helium will occupy vacancy sites, leading to a tin interstitial excess. Sputtering and phase separation of the tin oxide skin, which is impermeable for tin atoms, create holes and will allow the epitaxial overgrowth to start. Simultaneously, helium accumulates inside the irradiated spheres. Fitting the simulations to the experimentally observed morphology allows us to estimate the tin to tin-oxide interface energy to be 1.98 J m−2 . Our approach allows the targeted initiation and in situ observation of interstitial diffusion-driven effects to improve the understanding of the tin-whisker growth mechanism observed in lead-free solders.
Keywords: helium ion microscope; tin whisker growth; defect kinetics
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34525) publication
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Data publication: Epitaxial lateral overgrowth of tin spheres driven and …
ROBIS: 34526 HZDR-primary research data are used by this (Id 34525) publication
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The Journal of Physical Chemistry Letters 126(2022), 16332-16340
DOI: 10.1021/acs.jpcc.2c03707
Cited 1 times in Scopus
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- Final Draft PDF 12,1 MB Secondary publication
Permalink: https://www.hzdr.de/publications/Publ-34525
Development of Mechanistic Neural Mass (mNM) Models that Link Physiology to Mean-Field Dynamics
Abstract
Brain rhythms emerge from the mean-field activity of networks of neurons. There have been many efforts to build mathematical and computational embodiments in the form of discrete cell group activities termed neural masses to understand particular the origins of evoked potentials, intrinsic patterns of activities such as theta, regulation of sleep, Parkinson's disease related dynamics, and instabilities such as seizure dynamics. As originally utilized, standard neural masses convert input through a sigmoidal function to a firing rate, and firing rate through a synaptic alpha function to other masses. Here we define a process to build almost from first principles (i.e. Hodgkin Huxley type models) mean field models of different neuron types that duplicate the stability, firing rate, and associated bifurcations as function of relevant slow variables - such as extracellular potassium - and synaptic current; and whose output is both firing rate and impact on the slow variables - such as transmembrane potassium flux. Small networks composed of just excitatory and inhibitory masses demonstrate expected dynamical states including stable firing, runaway excitation and depolarization block, and these transitions change in biologically observed ways with changes in extracellular potassium and excitatory-inhibitory balance.
Keywords: Excitation-Inhibition imbalance; Depolarization Block; Neural Mass Model; Brain Networks; Pathophysiology
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Frontiers in Network Physiology 2(2022), 911090
DOI: 10.3389/fnetp.2022.911090
Cited 1 times in Scopus
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Permalink: https://www.hzdr.de/publications/Publ-34523
Biogeographic Regionalization: Freshwater
Dias, M. S.; Oikonomou, A.; Su, G.
Abstract
Defining the number and geographical borders of regions containing similar organisms and high levels of endemism can shed light on the evolution and distribution of life on Earth. We provide an historical overview of studies delineating the global biogeographical regions of freshwater organisms, mainly focusing on fish, to understand whether aquatic and terrestrial organisms share similar distribution patterns. Then, we provide a geographical and biological description giving special attention to major biogeographical fish patterns and taxa present in each of the considered regions.
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Book chapter
in: Encyclopedia of Biodiversity 3rd edition, Online: Elsevier, 2022
DOI: 10.1016/B978-0-12-822562-2.00044-X
Permalink: https://www.hzdr.de/publications/Publ-34522
Modelling Cross-border Mobility During Disease Outbreak
Abstract
Due to the COVID-19 pandemic various cross-border policies such as mandatory testing, quarantining upon arrival, travel restrictions have been implemented by the countries to minimize the risk of disease import. The strictness of these measures has varied over time. The aim of this study is twofold. First, we develop a spatially explicit SIR-type compartmental model to evaluate the impact of cross-border mobility between two countries on the disease dynamics under different epidemic conditions. We see a significant change in the time to reach the peak of infection if the cross-border mobility is permitted during disease outbreak. Moreover, our study shows that allowing cross-border mobility shortens the difference in peak timings in two countries in comparison to the scenario with no cross-border flux. Next, we present a method using stochastic simulation for estimating cross-border mobility flux between two regions from the difference in peak-timing in infection under some reasonable assumptions.
Keywords: Mathematical modelling; Infectious disease; COVID-19; Cross-border mobility; Compartmental modelling
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Poster
12th European Conference on Mathematical and Theoretical Biology, 19.-23.09.2022, Heidelberg, Germany
Permalink: https://www.hzdr.de/publications/Publ-34521
Molten salt electrolyte in Na-ZnCl2 solid-electrolyte battery for electricity storage
Kumar, S.; Ding, W.; Bonk, A.; Heinz, M. V. F.; Weber, N.; Bauer, T.
Abstract
Increasing share of intermittent renewable energy resources such as PV and wind energy in the grid has led to increasing demand in grid-scale stationary storage batteries. The commercial ZEBRA (Na-NiCl2) batteries are one kind of low-cost stationary storage batteries, which have been developed in the past decades to increase their efficiency, safety and performance.
Replacing Ni with abundant and low-cost Zn (i.e., Na-ZnCl2 batteries) could make these batteries more cost-effective (cut down around 46 and 20% of the cell material and overall battery costs). Fig. 1 shows the material cost breakdown of Na–NiCl2 and Na-ZnCl2 batteries. Compared to ZEBRA battery (Ni: 63%), the Zn electrode in the Na-ZnCl2 battery has a much lower material cost share (Zn: 23%). Several studies have been done on these novel Na-ZnCl2 batteries, but there is still a lack of understanding for the electrolyte system (AlCl3-NaCl-ZnCl2) of the Na-ZnCl2 batteries in terms of melting temperature, phase changes and salt vapor pressures at various temperatures. These properties of the salt electrolyte are vital for the battery design and optimization.
In this work (as part of the SOLSTICE EU H2020 project for development of Na-ZnCl2 batteries), the simulation-assisted in-depth analysis on the AlCl3-NaCl-ZnCl2 salt electrolyte for the Na-ZnCl2 solid electrolyte batteries was performed via the thermodynamic software FactSage and thermo-analytical techniques like Differential Scanning Calorimetry (DSC) and OptiMeltTM. Moreover, an estimation model for the unit storage salt material cost (i.e., salt cost/storage capacity, $/kWh) was developed and used for the pre-optimization of this salt electrolyte.
The simulation and experimental results show that increasing the concentration of AlCl3 in the AlCl3-(NaCl)2-ZnCl2 salt mixture decreases the melting point significantly, which could enlarge the charge/discharge range of the battery. However, when containing more than 40 mol% AlCl3, the vapor pressure of the salt mixture could be above 1 atm at 300 °C. Thus, this factor is suggested to be considered in the electrolyte selection and battery operation for the battery safety. Moreover, the estimation results of the unit storage salt material cost in Fig. 2 indicate that as AlCl3 has a much higher cost than NaCl, increasing the concentration of AlCl3 in the AlCl3-(NaCl)2-ZnCl2 salt electrolyte from 5 to 50 mol% could increase the unit storage salt material cost from 0.2 to 2.8 $/kWh, when the salt electrolyte in the full discharged state and Zn metal are used as the starting cathode in the battery. However, when the salt contains a low concentration of AlCl3 (e.g., 5 mol%), the possibly low conductivity of the salt electrolyte due to its high melting temperature (small ratio of the liquid salt phase) could limit the battery performance. While the results of this study, such as the AlCl3-(NaCl)2-ZnCl2 phase diagramme, its vapour pressure and price will be very beneficial for preselecting possible salt compositions, the final selection will need to be made based on real battery tests and accounting for further issues, such as corrosion, as well. These experiments are currently under way.
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Lecture (Conference)
International Renewable Energy Storage Conference, 20.09.2022, Düsseldorf, Deutschland
Permalink: https://www.hzdr.de/publications/Publ-34520
Influence of surface roughness on the sorption of Cm(III) on crystalline-water interfaces
Demnitz, M.; Schymura, S.; Neumann, J.; Müller, K.; Schmidt, M.
Abstract
Many countries plan to use deep geological repositories to dispose of their highly radioactive nuclear waste. Internationally, crystalline rock is a potential host rock because of its strong geotechnical stability, low permeability and low solubility. After a potential water ingress into a nuclear waste repository, radionuclides might be mobilized in aqueous solution. The topographical surface features affect the speciation and therefore retention potential of radionuclides on the host rock. Therefore, there is a need for using sophisticated techniques that allow to characterize the nanostructure of such crystalline rock with spatial resolution and the molecular speciation of the actinides thereon. As a representative for trivalent actinides, such as Am(III), Np(III), and Pu(III), we have chosen the actinide Cm(III). It possesses excellent luminescence properties, allowing us to determine Cm(III) sorption uptake and molecular speciation.
Our investigations focused on cleaved orthoclase (K-feldspar) single crystals and thin slices of different crystalline rocks stemming from the Grimsel test site (GTS) in Switzerland. Cleaved pieces of orthoclase or thin sections of the crystalline rocks were immersed in a sorption solution containing Cm(III). The experiments were undertaken at selected pH values (5.5, 6.9 and 7.3) and different inherent mineralogical complexity of the systems. Subsequently, we applied correlated spectroscopy to analyze the samples. Thus, we were able to correlate mineralogy, topography, and grain boundary effects with radionuclide speciation, allowing us to identify important radionuclide retention processes and parameters. [1, 2].
We observed that Cm(III) sorption uptake and speciation on orthoclase single crystals depends not exclusively on the mineral phase and the solution conditions, such as the pH, but also on the surface roughness. At pH 5.5 the sorption uptake differed between low and high surface roughness areas, while the speciation on both areas remained largely similar. Increasing the pH to 6.9 not only increased the overall sorption uptake, also the speciation between smoother and rougher surfaces differed. Using luminescence peak and lifetime analysis we could determine that the speciation is highly dependent on the availability on strong sorption sites. Based on our results we proposed a simple model for Cm(III) sorption on an orthoclase surface.
Further we compared the Cm(III) speciation on orthoclase singe crystals with orthoclase mineral grains on a thin section prepared from Grimsel specimen rock. The sorption was now influenced additionally by the presence of a heterogeneous surface, affecting the strength and form of surface sorbed Cm(III) species.
We conclude that in addition to mineral composition, surface roughness needs to be considered adequately by reactive transport models to describe interfacial speciation of contaminants and respective retention patterns for the safety assessments of nuclear waste repositories.
Acknowledgements:
This work has been developed in the frame of the iCross project. We gratefully acknowledge funding provided by the German Federal Ministry of Education and Research (BMBF, Grant 02NUK053) and the Helmholtz Association (Grant SO-093).
[1] Molodtsov et al. (2019): Sorption of Eu(III) on Eibenstock granite studied by µTRLFS: A novel spatially-resolved luminescence-spectroscopic technique – In: Scientific Reports, 9, Article Number 6287.
[2] Demnitz et al. (2021): Effects of surface roughness and mineralogy on the sorption of Cm(III) on crystalline rock– In: Journal of Hazardous Materials, Volume 423, Part A , 127006.
Keywords: luminescence; speciation; Cm; crystal; interface; crystalline; roughness; topography; microscopy; spatial
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Lecture (Conference) (Online presentation)
28. Tagung der Fachsektion Hydrogeologie e. V. in der DGGV e.V., 23.-25.03.2022, Jena, Germany
Permalink: https://www.hzdr.de/publications/Publ-34518
Spatially resolved sorption of Cm(III) on crystalline rock: influence of surface roughness and mineralogy
Demnitz, M.; Molodtsov, K.; Schymura, S.; Schierz, A.; Müller, K.; Schmidt, M.
Abstract
Many countries will use deep geological repositories to dispose of highly active nuclear waste. Crystalline rock is a potential host rock because of its strong geotechnical stability, low permeability and low solubility; however, its inherent mineralogy is heterogeneous, consisting of a wide set of minerals in varying amounts. Therefore, there is a need for using sophisticated techniques that allow spatial resolution to characterize the nanostructure of such crystalline rock surfaces and the speciation of the actinides therein. As a representative for trivalent actinides, such as Am(III), Np(III), and Pu(III), which are expected to be present due to the reducing conditions encountered in a deep geological repository, we have chosen the actinide Cm(III). Cm(III) possesses excellent luminescence properties, which allows us to not only examine the sorption uptake but also the speciation of Cm(III) on the surface.
We combined spatially resolved investigation techniques, such as vertical scanning interferometry, calibrated autoradiography, and Raman microscopy coupled to micro-focus time-resolved laser-induced luminescence spectroscopy (µTRLFS) (Molodtsov et al., 2019). Thus, we were able to correlate mineralogy, surface roughness, and grain boundary effects with radionuclide speciation, allowing us to identify important radionuclide retention processes and parameters.
Investigations focused on granite from Eibenstock (Germany) and migmatised gneiss from Bukov (Czech Republic). Cm(III) sorption on the rock's constituting minerals – primarily feldspar, mica and quartz – was analyzed quantitatively and qualitatively. We observed that Cm(III) sorption uptake and speciation depends not only on the mineral phase but also the surface roughness (Demnitz et al., 2021). An increasing surface roughness leads to higher sorption uptake and a stronger coordination of the sorbed Cm(III). On the same mineral grains sorption differed significantly depending if an area exhibits a low or high surface roughness. In the case that one mineral phase dominates the sorption process, sorption of Cm(III) on other mineral phases will only occur at strong binding sites, typically where surface roughness is high. Areas of feldspar and quartz with high surface roughness additionally showed the formation of sorption species with particularly high sorption strength that could either be interpreted as Cm(III) incorporation species or ternary complexes on the mineral surface (Demnitz et al., 2021).
We conclude that in addition to mineral composition, surface roughness needs to be adequately considered to describe interfacial speciation of contaminants and respective retention patterns for the safety assessments of nuclear waste repositories.
Demnitz, M., Molodtsov, K., Schymura, S., Schierz, A., Müller, K., Jankovsky, F., Havlova, V., Stumpf, T., and Schmidt, M.: Effects of surface roughness and mineralogy on the sorption of Cm(III) on crystalline rock, J. Hazard. Mater. Pt. A, 423, 127006, https://doi.org/10.1016/j.jhazmat.2021.127006, 2021.
Molodtsov, K., Schymura, S., Rothe, J., Dardenne, K., and Schmidt, M.: Sorption of Eu(III) on Eibenstock granite studied by µTRLFS: A novel spatially-resolved luminescence-spectroscopic technique, Sci. Rep.-UK, 9, 6287, https://doi.org/10.1038/s41598-019-42664-2, 2019.
Keywords: luminescence; speciation; Cm; host rock; interface; crystalline; roughness; topography; microscopy; spatial
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Lecture (Conference)
Interdisciplinary research symposium On the safety of nuclear disposal practices 2021, 10.-12.11.2021, Berlin, Germany
DOI: 10.5194/sand-1-145-2021
Permalink: https://www.hzdr.de/publications/Publ-34517
Influence of surface roughness on the sorption of Cm(III)
Demnitz, M.; Schymura, S.; Neumann, J.; Müller, K.; Schmidt, M.
Abstract
INTRODUCTION
Many countries will use deep geological repositories to dispose of their highly radioactive nuclear waste. With an international perspective, crystalline rock is a potential host rock because of its strong geotechnical stability, low permeability and low solubility. However, its inherent mineralogy is heterogeneous, consisting of a wide set of minerals in varying amounts. Therefore, there is a need for using sophisticated techniques that allow to characterize the nanostructure of such crystalline rock surfaces with spatial resolution and the molecular speciation of the actinides thereon. As a representative for trivalent actinides, such as Am(III), Np(III), and Pu(III), which are expected to be present due to the reducing conditions encountered in a deep geological repository, we have chosen the actinide Cm(III). It possesses excellent luminescence properties, allowing us to determine sorption uptake and molecular speciation of Cm(III) on the surface.
DESCRIPTION OF THE WORK
Investigations focused on cleaved orthoclase (K-feldspar) single crystals as well as different crystalline rocks stemming from various regions in Europe. Cleaved pieces of orthoclase or thin sections of the crystalline rocks were immersed in a sorption solution containing [Cm(III)] = 5∙10-7 – 10-5 M. The experiments were undertaken at selected pH values (5.0 and 6.9) and different inherent mineralogical complexity of the systems. Subsequently, we applied correlated spectroscopy to analyze the samples. We combined vertical scanning interferometry, calibrated autoradiography, and Raman microscopy coupled to µTRLFS. Thus, we were able to correlate mineralogy, topography, and grain boundary effects with radionuclide speciation, allowing us to identify important radionuclide retention processes and parameters. For experimental details, see [1].
RESULTS AND DISCUSSION
We observed that Cm(III) sorption uptake and speciation depends not only on the mineral phase, but also the surface roughness. Already on single crystal orthoclase an increasing surface roughness leads to higher sorption uptake (see Fig. 1) and to a stronger coordination of the sorbed Cm(III).
Increasing the mineral complexity of the system further, we used thin sections of various crystalline rocks, consisting mainly of feldspar, quartz, and mica. We observed significant differences in sorption uptake on individual mineral phases as well as the resulting speciation. In case that one mineral phase dominates the sorption process, e.g. amphibole, sorption of Cm(III) on other mineral phases will only occur at strong binding sites, typically where surface roughness is high. Areas of feldspar and quartz with high surface roughness additionally showed the formation of sorption species with particularly high sorption strength that could either be interpreted as Cm(III) incorporation species or adsorbed ternary complexes on the mineral surface.[2]
At pH values of around 6.8 Cm(III) generally sorbs more weakly to the surface, while preferentially targeting mineral phases such as mica instead of feldspar or quartz. At a higher pH of 8.0 the sorption uptake on other mineral phases increases, with a general trend towards more strongly bound Cm(III) surface species.
We conclude that in addition to mineral composition, surface roughness needs to be considered adequately by reactive transport models to describe interfacial speciation of contaminants and respective retention patterns for the safety assessments of nuclear waste repositories.
Acknowledgements:
This work has been developed in the frame of the iCross project. We gratefully acknowledge funding provided by the German Federal Ministry of Education and Research (BMBF, Grant 02NUK053) and the Helmholtz Association (Grant SO-093).
REFERENCES
1. Molodtsov et al., “Sorption of Eu(III) on Eibenstock granite studied by µTRLFS: A novel spatially-resolved luminescence-spectroscopic technique” Scientific Reports, 9, Article Number 6287 (2019), https://doi.org/10.1038/s41598-019-42664-2.
2. Demnitz et al., “Effects of surface roughness and mineralogy on the sorption of Cm(III) on crystalline rock” Journal of Hazardous Materials, (2021), https://doi.org/10.1016/j.jhazmat.2021.127006.
Keywords: luminescence; speciation; Cm; crystal; interface; crystalline; roughness; topography; microscopy; spatial
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Poster
(Online presentation)
TransRet2020 - Workshop on Processes Influencing Radionuclide Transport and Retention, 12.04.-13.10.2021, Karlsruhe, Germany
Permalink: https://www.hzdr.de/publications/Publ-34516
Electronic pair alignment and roton feature in the warm dense electron gas
Abstract
The study of matter under extreme densities and temperatures as they occur e.g. in astrophysical objects and nuclear fusion applications has emerged as one of the most active frontiers in physics, material science, and related disciplines. In this context, a key quantity is given by the dynamic structure factor S(q,ω), which is probed in scattering experiments -- the most widely used method of diagnostics at these extreme conditions. In addition to its crucial importance for the study of warm dense matter, the modeling of such dynamic properties of correlated quantum many-body systems constitutes one of the most fundamental theoretical challenges of our time. Here we report a hitherto unexplained roton feature in S(q,ω) of the warm dense electron gas [1], and introduce a microscopic explanation in terms of a new electronic pair alignment model [2]. This new paradigm will be highly important for the understanding of warm dense matter, and has a direct impact on the interpretation of scattering experiments. Moreover, we expect our results to give unprecedented insights into the dynamics of a number of correlated quantum many-body systems such as ultracold helium, dipolar supersolids, and bilayer heterostructures.
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Lecture (others)
Theorie-Seminar am Insitut für Theoretische Physik und Astrophysik der Christian-Albrechts Universität zu Kiel., 12.04.2022, Kiel, Germany
Permalink: https://www.hzdr.de/publications/Publ-34515
Update of the Bunch Arrival Time Monitor at ELBE
Kuntzsch, M.; Maalberg, A.; Schwarz, A.; Zenker, K.; Czwalinna, M. K.; Kral, J.
Abstract
The bunch arrival time monitor (BAM) at the radiation source ELBE has been upgraded twofold. In order to achieve a higher precision a new frontend has been designed, based on a development by DESY, that uses state of the art 50 GHz electro-optical modulators (EOMs). The frontend allows for thermal control of critical components and monitoring of system parameters. The modulated EOM signals and monitoring data are distributed to a new readout electronic. The new MicroTCA-based receiveris based on a dedicated FMC card developed at DESY that is installed on an FMC25 carrier board. The arrival time is calculated on a FPGA with low latency and can be used for machine diagnostic. The code has been adapted to enable the processing of a data stream of the continuous train of electron bunches, allowing for the implementation of a cw beam based feedback in a next step. The contribution will describe the BAM setup as well as the performance measured at the ELBE accelerator.
Keywords: BAM; ELBE; arrival time; synchronization
Involved research facilities
- Radiation Source ELBE DOI: 10.17815/jlsrf-2-58
Related publications
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 34514) publication
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Poster
International Particle Accelerator Conference IPAC 2022, 12.-17.06.2022, Bangkok, Thailand
Permalink: https://www.hzdr.de/publications/Publ-34514
Identification of color pigments in wall paintings of Oscar Schlemmer
Hennig, C.
Abstract
Residuals of wall paintings from Bauhaus artist Oscar Schlemmer have been re-discovered recently. The restauration strategy of these precious objects requires a phase identification of the color pigments. The study includes the identification of potential decomposition mechanisms, as the wall paintings were in contact with chemicals of the glue from overlaying wall paper. Some coloring minerals were identified by combining high-resolution powder diffraction (PXRD) and x-ray fluorescence spectroscopy (XRF) using the new diffractometers at the Rossendorf Beamline (ROBL).
The Bauhaus revolutionized creative and artistic thinking and work worldwide. Walter Gropius employed a series of acclaimed artists as professors, among them Oskar Schlemmer, Wassili Kandinsky, Lyonel Feininger and Paul Klee. Adolf Meier, head of the architectural office of Walter Gropius, commissioned Oskar Schlemmer with wall paintings in his apartment for the first Bauhaus exhibition in 1923. Oskar Schlemmer, who was 1922-1925 the head of the Bauhaus studio for wall paintings, performed the work with Werner Gilles. During the Nazi regime, Schlemmer’s work was classified as degenerate art. Many of his wall paintings were overpainted. The wall paintings in Meier’s former apartment fell into oblivion. It was in the 1990s that Bauhaus research became aware of the existence of these wall paintings, which are only documented by two black and white photos from the time they were created.
In 2018, the apartment became subject of restoration studies. For this purpose, a network of institutions was created to identify the color scheme of the wall paintings and to generate a detailed 3D model of the room. The identification of the original color substances of the paintings remains a demanding issue as there are only residuals available. Schlemmer used partly new organic color material which was identified by spectroscopic techniques. A part of the paints is based on natural or synthetic mineral phase. These substances appear usually in a crystalline form and were identified with XRD. Heavy metals were identified with XRF spectroscopy. The small size of the color fragments, which were released from the walls, have microscopic dimensions of 10-30µm. This makes it impossible to perform phase identi¬fication with conventional laboratory equipment. The results of the synchrotron based XRD and XRF measurements from ROBL will be presented.
Involved research facilities
- Rossendorf Beamline at ESRF DOI: 10.1107/S1600577520014265
Related publications
- DOI: 10.1107/S1600577520014265 is cited by this (Id 34513) publication
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Invited lecture (Conferences)
Das Raumkunstwerk Wohnraum Adolf Meyer in Weimar im Kontext der Entwicklung des Bauhauses, 20.04.2022, Weimar, Germany
Permalink: https://www.hzdr.de/publications/Publ-34513
Machine Learning Collaboration-as-a-service at Helmholtz
Steinbach, P.; Hoffmann, H.; Tanveer, M.; Schmerler, S.; Starke, S.
Abstract
Machine Learning (ML) based methods are proliferating in industry, society, science and physics in particular in the last years. Not only do ML tools allow inferences from experimental data, but also have shown to be an inroads to previously unreachable theoretical or experimental domains. In this presentation, I'll introduce Helmholtz AI as a funded networking activity within Helmholtz to support matter research in using ML for science. I'll dive into how and why the program is split into research and collaboration-as-a-service staff. If time allows, I'll discuss how we approach ML projects with scientists from a consulting point of view.
Keywords: machine learning; consulting; academia; science; services; Helmholtz AI
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Invited lecture (Conferences) (Online presentation)
Seminar des ORIGINS Data Science Laboratory Munich, Einladung durch Lukas Heinrich, 08.04.2022, virtuell, Germany
DOI: 10.6084/m9.figshare.19550815.v1
Permalink: https://www.hzdr.de/publications/Publ-34512
Effects of electrically conductive walls on turbulent magnetohydrodynamic flow in a continuous casting mold
Blishchik, A.; Glavinic, I.; Wondrak, T.; van Odyck, D.; Kenjereš, S.
Abstract
In the present study, we have performed a series of numerical simulations of the turbulent liquid metal flow in a laboratory-scale setup of the continuous casting. The liquid metal flow was subjected to an external non-uniform magnetic field reproducing a realistic electromagnetic brake (EMBr) effect. The focus of this research was on the effects of the finite electrical conductivity of Hartmann walls on the flow and turbulence in the mold. To be able to simulate distributions of the electric potential and current in both the fluid and solid wall domains, we applied our recently developed and validated in-house conjugate MHD solver based on the open-source code OpenFOAM. The dynamic Large Eddy Simulation (LES) method was used to simulate the turbulent flow. The results obtained for the neutral (non-MHD) and MHD cases over a range of the imposed EMBr strengths – all for the perfectly electrically insulated walls – were compared with the available Ultrasound Doppler Velocimetry (UDV) measurements. A good agreement between simulations and experiments was obtained for all simulated cases. Next, we completed a series of simulations including a wide range of the finite electric conductivities (ranging from a weakly to perfectly conducting wall conditions) of the Hartmann walls for a fixed value of the imposed EMBr. The obtained results demonstrated a significant influence of the electric wall conductivities on the flow and turbulence reorganization. It is expected that here provided insights can be applicable for the new generation of the laboratory- and real-scale continuous casting setups.
Keywords: MHD; Magnetic field; Lorentz force; OpenFOAM; Electrically conducting walls; Dynamic LES; Continuous casting
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International Journal of Heat and Fluid Flow 95(2022), 108967
DOI: 10.1016/j.ijheatfluidflow.2022.108967
Cited 3 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34511
Depth-Adjustable Magnetostructural Phase Transition in Fe₆₀V₄₀ Thin Films
Anwar, M. S.; Cansever, H.; Boehm, B.; Gallardo, R.; Hübner, R.; Zhou, S.; Kentsch, U.; Rauls, S.; Eggert, B.; Wende, H.; Potzger, K.; Faßbender, J.; Lenz, K.; Lindner, J.; Hellwig, O.; Bali, R.
Abstract
Phase transitions occurring within spatially confined regions can be useful for generating nanoscale material property modulations. Here we describe a magneto-structural phase transition in a binary alloy, where a structural transition from short range order (SRO) to body centered cubic (bcc) results in the formation of depth-adjustable ferromagnetic layers, which reveal application-relevant magnetic properties of high saturation magnetitzation (Ms) and low Gilbert damping (α). Here we use Fe₆₀V₄₀ binary alloy films which transform from initially Ms = 17 kA/m (SRO structure) to 747 kA/m (bcc structure) driven by atomic displacements caused by penetrating ions. Simulations show that estimated ~1 displacement per atom triggers a structural transition, forming homogeneous ferromagnetic layers. The thickness of ferromagnetic layer increases as a step-like function of the ion-fluence. Microwave excitations of the ferromagnetic/non-ferromagnetic layered system reveals an α = 0.0027 ± 0.0001. The combination of nanoscale spatial confinement, low α and high Ms provide a pathway for the rapid patterning of magnetic and microwave device elements.
Keywords: Magneto-structural correlations; Phase transitions; Magnetic thin films; Ion-irradiation; Short-range order
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34510) publication
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ACS Applied Electronic Materials 4(2022)8, 3860-3869
DOI: 10.1021/acsaelm.2c00499
Cited 3 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34510
Spatially-resolved sorption of Cm(III)/Eu(III) on heterogeneous crystalline rocks
Molodtsov, K.; Schymura, S.; Schierz, A.; Müller, K.; Stumpf, T.; Schmidt, M.
Abstract
Many countries will use deep geological repositories (DGR) to store their heat generating high-level radioactive waste. Crystalline rock is one of the potential host rocks, but possesses high inherent mineralogical heterogeneity. Since the molecular retardation reactions of radionuclides at water-mineral interfaces depend mainly on the availability of reactive sites, heterogeneity is expected to play a major role for contaminant transport in a DGR. The fundamental understanding and transferrability of this heterogeneity into modeling different transport scenarios is of urgent need for a reliable safety assessment of a repository. Through correlation of spectroscopic information with spatial resolution we characterized the nanostructure of crystalline rock surfaces and the surface speciation of selected radionuclides, namely Eu(III) and Cm(III) thereon. We utilized vertical scanning interferometry, autoradiography, and Raman microscopy in combination with µTRLFS – microfocus time-resolved laser-induced fluorescence spectrsocopy.[1] Using these novel techniques the surface speciation of Eu(III) and Cm(III) can be qualified and quantified. Moreover, we were able to correlate mineralogy, topography, and grain boundary effects with radionuclide speciation, allowing us to draw conclusions about radionuclide retention mechanisms on mineral surfaces.
Our work focussed on granite from Eibenstock (Germany) and migmatised gneiss from the Bukov URL (Czech Republic). We characterized the sorption of Cm(III) and Eu(III) on feldspar, mica, quartz and accessory mineral areas on both rocks. [1-3] Using autoradiography and µTRLFS we linked the sorption uptake on the heterogeneous surface with the mineralogy and the surface roughness, showing that surface roughness within the same mineral phase has an impact not only on the amount of sorption uptake, but also the radionuclide surface speciation and thus bond strengths and reversibility.
Using µTRLFS we identified how the speciation correlates to mineral phases and surface roughness. A higher surface roughness induces more binding sites available to Eu(III) and Cm(III) resulting in strongly bound trivalent radionuclide surface complexes and a higher sorption uptake. On quartz and feldspar high surface roughness leads to ternary Cm(III) complex formation on the surface presumably with silicate and carbonate ions avaliable in solution.
In comparison to Eibenstock granite, Bukov gneiss inherently contained a greater number of accessory minerals. We observed that some of them seem to dominate the sorption process, lowering the sorption of Eu(III) on the major components feldspar and quartz in comparison to Eibenstock granite.[2] The leftover Cm(III)/Eu(III) sorb on stronger and preferential sorption sites, which are located in regions exhibiting a high surface roughness.[3] This could be clearly proven for Cm(III)/Eu(III) surface complexes being stronger on feldspar. With this work we demonstrated a successful upscaling approach to derive molecular understanding of radionuclide retention processes from the nm to the cm sacle.
References
[1] Molodtsov, Sorption of Eu(III) on Eibenstock granite studied by µTRLFS: A novel spatially-resolved luminescence-spectroscopic technique, Scientific Reports, 9, 6287 (2019).
[2] Molodtsov, A µTRLFS investigation on the sorption of Eu3+ on Bukov migmatised gneiss on the molecular level, Environmental Science & Technology, submitted.
[3] Demnitz, A spatially-resolved study on the sorption of Cm(III) on different crystalline rocks using surface investigation techniques, in preparation.
Keywords: luminescence; trlfs; surface; mineralogy; topography; interface; curium; europium; correlative; spectroscopy
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Lecture (Conference) (Online presentation)
2. Tage der Standortauswahl, 11.-12.02.2021, Freiberg, Germany
Permalink: https://www.hzdr.de/publications/Publ-34509
Contemporary environment and historical legacy explain functional diversity of freshwater fishes in the world rivers
Su, G.; Tedesco, P. A.; Toussaint, A.; Villéger, S.; Brosse, S.
Abstract
Aim
Regional taxonomic diversity (species richness) is strongly influenced by a joint effect of the current processes (habitat and energy availability) and historical legacies (past climate and geography), but it is still unclear how those historical and current environmental drivers have shaped the functional diversity of species assemblages.
Major taxa studied
Freshwater fish.
Location
Global.
Time period
1960s–2000s.
Methods
We combined the spatial occurrences over 2,400 river basins world-wide and the functional traits measured on 10,682 freshwater fish species to quantify the relative role of the habitat, climate and historical processes on the current global fish functional diversity. To avoid any correlation between taxonomic diversity and functional diversity, we controlled for differences in the number of species (species richness) between rivers. Functional diversity was considered through three complementary facets: functional richness, functional dispersion and functional identity.
Results
The habitat-related variables explained most of the gradient in functional richness, verifying the habitat size–diversity hypothesis. In contrast, the historical climate–geography legacies markedly imprinted the functional dispersion and functional identity patterns, leading to a balanced influence of the current and historical processes. Indeed, the distribution of morphological traits related to fish dispersal was explained largely by the glaciation events during the Quaternary, leading to strong latitudinal gradients.
Main conclusions
This study provides new insights into the role of historical and current environmental determinants on the functional structure of fish assemblages and strengthens the proposal that the independence of facets of functional diversity from the species richness makes them essential biodiversity variables to understand the structure of communities and their responses to global changes.
Related publications
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Data publication: Contemporary environment and historical legacy explain …
ROBIS: 34392 HZDR-primary research data are used by this (Id 34508) publication
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Global Ecology and Biogeography 31(2022)4, 700-713
DOI: 10.1111/geb.13455
Cited 13 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34508
FISHMORPH: A global database on morphological traits of freshwater fishes
Brosse, S.; Charpin, N.; Su, G.; Toussaint, A.; Herrera-R, G. A.; Tedesco, P. A.; Villéger, S.
Abstract
Motivation
Global freshwater fish biodiversity and the responses of fishes to global changes have been explored intensively using taxonomic data, whereas functional aspects remain understudied owing to the lack of knowledge for most species. To fill this gap, we compiled morphological traits related to locomotion and feeding for the world freshwater fish fauna based on pictures and scientific drawings available from the literature.
Main types of variables contained
The database includes 10 morphological traits measured on 8,342 freshwater fish species, covering 48.69% of the world freshwater fish fauna.
Spatial location and grain
Global.
Major taxa and level of measurement
The database considers ray-finned fishes (class Actinopterygii). Measurements were made at the species level.
Software format
.csv.
Main conclusion
The FISHMORPH database provides the most comprehensive database on fish morphological traits to date. It represents an essential source of information for ecologists and environmental managers seeking to consider morphological patterns of fish faunas throughout the globe, and for those interested in current and future impacts of human activities on the morphological structure of fish assemblages. Given the high threat status of freshwater environments and the biodiversity they host, we believe this database will be of great interest for future studies on freshwater ecology research and conservation.
Related publications
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Dataset in paper 'FISHMORPH: A global database on morphological traits of …
ROBIS: 33638 HZDR-primary research data are used by this (Id 34507) publication
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Global Ecology and Biogeography 30(2021)12, 2330-2336
DOI: 10.1111/geb.13395
Cited 45 times in Scopus
Downloads
- Open Access Version from hal.archives-ouvertes.fr
- Secondary publication expected
Permalink: https://www.hzdr.de/publications/Publ-34507
Spatially resolved sorption of Cm(III) on crystalline rock: influence of surface roughness and mineralogy
Demnitz, M.; Molodtsov, K.; Schymura, S.; Schierz, A.; Müller, K.; Schmidt, M.
Abstract
Many countries will use deep geological repositories to dispose of their highly active nuclear waste. Crystalline rock is a potential host rock because of its high stability, heat resistance and low solubility. However, it possesses a high inherent mineralogical heterogeneity. Using sophisticated techniques that allow spatial resolution we characterized the nanostructure of such crystalline rock surfaces and the speciation of the actinide Cm(III) thereon.
Namely, we combined vertical scanning interferometry, calibrated autoradiography, and Raman microscopy coupled to µTRLFS (micro-focus time-resolved laser-induced spectroscopy).[1] Thus we were able to correlate mineralogy, topography, and grain boundary effects with radionuclide speciation, allowing us to identify important radionuclide retention processes and parameters.
Investigations focussed on granite from Eibenstock (Germany) and migmatised gneiss from Bukov (Czech Republic). Cm(III) sorption on the rock’s constituing minerals - primarily feldspar, mica and quartz - was analyzed quantitatively and qualitatively. We observed that Cm(III) sorption uptake and speciation depends not only on the mineral phase, but also the surface roughness. An increasing surface roughness leads to higher sorption uptake and a stronger coordination of the sorbed Cm(III). On the same mineral grains sorption differed significantly depending if an area exhibits a low or high surface roughness. In case that one mineral phase dominates the sorption process, sorption of Cm(III) on other mineral phases will only occur at strong binding sites, typically where surface roughness is high. Areas of feldspar and quartz with high surface roughness additionally showed the formation of sorption species with particularly high sorption strength that could either be interpreted as Cm(III) incorporation species or ternary complexes on the mineral surface.
We conclude that in addition to mineral composition, surface roughness needs to be considered adequately to describe interfacial speciation of contaminants and respective retention patterns for the safety assessments of nuclear waste repositories.
[1] Molodtsov, Schymura, Rothe, Dardenne & Schmidt (2019), Scientific Reports 9, 6287.
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Lecture (Conference) (Online presentation)
Goldschmidt Virtual 2021, 08.07.2021, Lyon, France
DOI: 10.7185/gold2021.3156
Permalink: https://www.hzdr.de/publications/Publ-34506
Mechanistic understanding of Curium(III) sorption on natural K feldspar surfaces
Demnitz, M.; Schymura, S.; Neumann, J.; Schmidt, M.; Schäfer, T.; Stumpf, T.; Müller, K.
Abstract
To assess a reliable safety case for future deep underground repositories for highly active nuclear waste the retention of radionuclides by the surrounding host rock must be understood comprehensively. Retention is influenced by several parameters such as mineral heterogeneity and surface roughness, as well as pore water chemistry (e.g., pH). However, the interplay between those parameters is not yet well understood. Therefore, we present a correlative spectromicroscopic approach to investigate sorption of the actinide Cm(III) on: 1) bulk K-feldspar crystals to determine the effect of surface roughness and pH (5.5 and 6.9) and 2) a large feldspar grain as part of a complex crystalline rock system to observe how sorption is influenced by the surrounding heterogeneous mineralogy. Our findings show that rougher K-feldspar surfaces exhibit increased Cm(III) uptake and stronger complexation. Similarly, increasing pH leads to higher surface loading and stronger Cm(III) binding to the surface. Within a heterogeneous mineralogical system sorption is further affected by neighboring mineral dissolution and competitive sorption between mineral phases such as mica and feldspar. The obtained results express a need for investigating relevant processes on multiple scales of dimension and complexity to better understand trivalent radionuclide retention by a potential repository host rock.
Keywords: luminescence; speciation; Cm; host rock; interface; crystalline; roughness; topography; microscopy; spatial
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Science of the Total Environment 843(2022), 156920
DOI: 10.1016/j.scitotenv.2022.156920
Cited 3 times in Scopus
Downloads
- Secondary publication expected
Permalink: https://www.hzdr.de/publications/Publ-34505
BIM - Biomedical Image analysis Models survey
Li, R.; Sharma, V.; Thangamani, S.; Yakimovich, A.
Abstract
This is meta-analysis repository for the program code and meta-data collected on open-source biomedical image analysis models. This repository is maintained as a continuous survey of published open-source models. Code is aimed at obtaining statistical summary of the meta-data.
Keywords: open source; machine learning; bioimage analysis; deep learning
Related publications
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Open-Source Biomedical Image Analysis Models: a Meta-analysis and Continuous …
ROBIS: 34501 is supplemented by this (Id 34504) publication
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Software in external data repository
Publication year 2022
Programming language: Python
System requirements: Python 3.9.7 seaborn 0.11.2 pandas 1.3.4 matplotlib 3.5.0
License: MIT (Link to license text)
Hosted on GitHub: Link to location
Permalink: https://www.hzdr.de/publications/Publ-34504
GUI Flow data
Abstract
- english version below -
Diese grafische Nutzeroberfläche in Form einer installirbaren standalone-Anwendung dient zur Visualisierung aus der Literatur bekannter experimenteller Datensätze und Strömungskarten für horizontal strömende Luft/Wasser-Systeme. Weiterhin sind Modelle und Strömungskarten aus der Literatur integriert, die für beliebige Stoffsysteme eine Vorhersage über die zu erwartenden Strömungsformen treffen. Zusätzlich erlauben Schnitstellen in Form von .txt-Dateien das Importieren eigener Datensätze, bzw. das Exportieren der visualisierten Inhalte.
Für die Richtigkeit der dargestellten Inhalte wird keine Haftung übernommen. Das Urheberrecht für die zugrundeliegenden Datensätze und Berechnungen liegt bei den Autoren der referenzierten Primärliteratur.
This graphical user interface in the form of an installable standalone application is used to visualize experimental data sets and flow maps known from the literature for horizontally flowing air/water systems. Furthermore, models and flow maps from the literature are integrated to predict the flow patterns for any fluid system. Additionally, data interfaces in the form of .txt files allow the import of own data sets, respectively the export of the visualized contents.
No liability is assumed for the correctness of the displayed contents. The copyright for the underlying data sets and calculations is held by the authors of the referenced primary literature.
Keywords: GUI; Interface; Flow data; flow regime maps; Strömungsdaten; Strömungskarten
Involved research facilities
- TOPFLOW Facility
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Software in the HZDR data repository RODARE
Publication date: 2022-04-01 Restricted access
DOI: 10.14278/rodare.1530
Versions: 10.14278/rodare.1531
Downloads
Permalink: https://www.hzdr.de/publications/Publ-34503
Fully encapsulated and stable black phosphorus field-effect transistors
Arora, H.; Fekri, Z.; Vekariya, Y. N.; Chava, P.; Watanabe, K.; Taniguchi, T.; Helm, M.; Erbe, A.
Abstract
Black phosphorus (BP) has quickly gained popularity in the scientific community owing to its interesting semiconducting properties, such as direct bandgap, high mobility, and intrinsic ambipolar behavior. However, its sensitivity to oxygen, moisture, and other air species has restricted its integration into active devices. Here, we employ lithography-free via-encapsulation scheme to fabricate fully-encapsulated BP-based field-effect transistors (FETs). The full encapsulation is achieved by sandwiching the BP layers between top and bottom hexagonal boron nitride (hBN) layers; top hBN passivating the BP layer from the environment and bottom hBN acting as a spacer and suppressing charge transfer to the BP layer from the SiO2 substrate. The embedded via-metal-electrodes allow us to perform reliable electrical measurements of the BP FETs. Based on our results, we find that the electronic properties of the via-encapsulated BP FETs are significantly improved compared to unencapsulated devices and a clear metal–insulator transition is observed which remained missing in the latter. We further establish that the via-contacting scheme leads to superior results compared to graphene-hBN heterostructures and bare hBN layers combined with evaporated metal contacts (both use top and bottom hBN to encapsulate BP) by revealing a higher mobility, lower hysteresis, and long-term ambient-stability in BP FETs.
Keywords: two-dimensional semiconductors; black phosphorus; field-effect transistors; hexagonal boron nitride; encapsulation
Involved research facilities
- Ion Beam Center DOI: 10.17815/jlsrf-3-159
Related publications
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 34502) publication
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Data: Fully encapsulated and stable black phosphorus field-effect transistors
ROBIS: 34592 HZDR-primary research data are used by this (Id 34502) publication
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Advanced Materials Technologies 8(2022)2, 2200546
DOI: 10.1002/admt.202200546
Cited 6 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34502
Open-Source Biomedical Image Analysis Models: a Meta-analysis and Continuous Survey
Li, R.; Sharma, V.; Thangamani, S.; Yakimovich, A.
Abstract
Open-source research software has proven indispensable in modern biomedical image analysis. A multitude of open-source platforms drive image analysis pipelines and help disseminate novel analytical approaches and algorithms. Recent advances in machine learning allow for unprecedented improvement in these approaches. However, these novel algorithms come with new requirements in order to remain open source. To understand how these requirements are met, we have collected 50 biomedical image analysis models and performed meta-analysis of their respective paper, source code, dataset and trained model parameters. We concluded that while there are many positive trends in openness, only a fraction of all publications makes all necessary elements available to the research community.
Keywords: deep learning; machine learning; bioimage analysis; open source
Related publications
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BIM - Biomedical Image analysis Models survey
ROBIS: 34504 is a supplement to this (Id 34501) publication
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Frontiers in Bioinformatics 2(2022), 912809
DOI: 10.3389/fbinf.2022.912809
Cited 1 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34501
Sequencing meets machine learning to fight emerging pathogens: A preview
Abstract
In searching for SARS-CoV variants-of-concern, pathogen sequencing is generating an impressive amount of data. However, beyond epidemiological use, these data contain cues fundamental to our understanding of pathogen evolution in the human population. Yet, to harness them, further development of computational methodology, such as machine learning, may be required. This preview discusses updates in machine learning to understand emerging pathogens.
Keywords: SARS-CoV2; machine learning; sequencing
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Patterns 3(2022)2, 100448
DOI: 10.1016/j.patter.2022.100448
ISSN: 2666-3899
Permalink: https://www.hzdr.de/publications/Publ-34497
A tandem segmentation-classification approach for the localization of morphological predictors of C. elegans lifespan and motility
Abstract
C. elegans is an established model organism for studying genetic and drug effects on aging, many of which are conserved in humans. It is also an important model for basic research, and C. elegans pathologies is a new emerging field. Here we develop a proof-of-principal convolutional neural network-based platform to segment C. elegans and extract features that might be useful for lifespan prediction. We use a dataset of 734 worms tracked throughout their lifespan and classify worms into long-lived and short-lived. We designed WormNet - a convolutional neural network (CNN) to predict the worm lifespan class based on young adult images (day 1 – day 3 old adults) and showed that WormNet, as well as, InceptionV3 CNN can successfully classify lifespan. Based on U-Net architecture we develop HydraNet CNNs which allow segmenting worms accurately into anterior, mid-body and posterior parts. We combine HydraNet segmentation, WormNet prediction and the class activation map approach to determine the segments most important for lifespan classification. Such a tandem segmentation-classification approach shows the posterior part of the worm might be more important for classifying long-lived worms. Our approach can be useful for the acceleration of anti-aging drug discovery and for studying C. elegans pathologies.
Keywords: aging; deep learning; Caenorhabditis elegans; interpretable machine learning; convolutional neural networks
Related publications
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Caenorhabditis elegans microscopy dataset with lifespan, movement and …
ROBIS: 34213 HZDR-primary research data are used by this (Id 34496) publication
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Aging 14(2022)4, 1665-1677
DOI: 10.18632/aging.203916
ISSN: 1945-4589
Cited 1 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34496
PaN Training Catalogue
Abstract
The source code of the training catalogue for the PaN community developed in the ExPaNDS and PaNOSC projects. The initial code was developed for the training portal TeSS developed in the ELIXIR project.
Keywords: data management; photon and neutron community; training catalogue
Related publications
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The Training Catalogue for Photon and Neutron Data Services
ROBIS: 34618 documents this (Id 34495) publication
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Software in external data repository
Publication year 2022
Programming language: Ruby on Rails
System requirements: ruby-2.7.4
License: BSD 3-Clause License (Link to license text)
Hosted on https://github.com/pan-training/training-catalogue: Link to location
Downloads
Permalink: https://www.hzdr.de/publications/Publ-34495
Model-independent determination of the dipole response of 66Zn using quasimonoenergetic and linearly polarized photon beams
Savran, D.; Isaak, J.; Schwengner, R.; Massarczyk, R.; Scheck, M.; Tornow, W.; Battaglia, G.; Beck, T.; Finch, S. W.; Fransen, C.; Friman-Gayer, U.; Gonzalez, R.; Hoemann, E.; Janssens, R. V. F.; Johnson, S.; Jones, M. D.; Kelly, N.; Kleemann, J.; Krishichayan, D. R. L.; O'Donnell, D.; Papst, O.; Sinclair, J.; Werner, V.; Wieland, O.; Wilhelmy, J.
Abstract
Photon strength functions are an important ingredient in calculations relevant for the nuclear synthesis of heavy elements. The relation to the photo-absorption cross section allows to experimentally constrain photon strength functions by investigating the photo-response of atomic nuclei.
We determine the photoresponse of 66Zn in the energy region of 5.6 MeV to 9.9 MeV and analyze the contribution of the decay channel back to the ground state. In addition, for the elastic channel electric and magnetic dipole transitions can be separated.
Nuclear resonance fluorescence experiments were performed using a linearly-polarized quasimonoenergetic photon beam at the High Intensity Gamma-ray Source. Photon beam energies in the energy range from 5.6 MeV to 9.9 MeV with an energy spread of about 3 % were selected in steps of 200 - 300 keV.
Two High-Purity Germanium detectors were used for the subsequent gamma-ray spectroscopy.
Full photo absorption cross sections are extracted from the data making use of the mono-energetic character of the photon beam. For the ground-state decay channel the average contribution of electric and magnetic dipole strength is disentangled. The average branching ratio back to the ground state is determined as well.
The new results show lower cross sections compared to the values extracted from experiments using bremsstrahlung. In the latter the average branching ratio to the ground state needs to be estimated from statistical model calculations in order to analyze the data. The calculations underestimate this branching ratio
compared to the values extracted within the present analysis, which would partly explain the high cross sections determined from the bremsstrahlung data.
Keywords: Nuclear structure; electromagnetic transitions; photon scattering; nuclear resonance fluorescence; polarized photon beams
Involved research facilities
- Radiation Source ELBE DOI: 10.17815/jlsrf-2-58
- γ-ELBE DOI: 10.58065/24020
Related publications
- DOI: 10.58065/24020 is cited by this (Id 34493) publication
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 34493) publication
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Physical Review C 106(2022), 044324
DOI: 10.1103/PhysRevC.106.044324
Cited 3 times in Scopus
Downloads
- Open Access Version from arxiv.org
- Secondary publication expected
Permalink: https://www.hzdr.de/publications/Publ-34493
Evaluation of raw data from THz source.
Abstract
The radiation source ELBE (Electron Linac for beams with high Brilliance and low Emittance) at the Helmholtz Centre Dresden Rossendorf (HZDR) can produce several kinds of secondary radiations. THz radiation is one of them and can be used with a typical pulse frequency of 100 kHz as a stimulation source for elementary low-energy degrees of freedom in matter. It was used in the "Phase-resolved Higgs response in superconducting cuprates" publication (DOI: 10.1038/s41467-020-15613-1). The raw data for this publication can be accessed on RODARE (DOI: 10.14278/rodare.277) and will be used to reproduce the figures from the publication. This Jupyter notebook enables the user to handle the raw data from an TELBE THz experiment. To sample the whole THz wave the laser path length is modified by moving specific mirrors. The raw data contains for each mirror position a binary file storing the signal spectra and a folder with gray scaled tiff files storing the jitter timing. Parts of the code are parallelized and can run on multiple cores. The execution time on a single core is roughly 15 min after downloading and extracting a 20 GB zip file.
Keywords: Jupyter Notebook; Thz2
Related publications
- URL: https://github.com/hzdr/TELBE-raw-data-evaluation/tree/0.1.1 is supplemented by this (Id 34492) publication
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Software in the HZDR data repository RODARE
Publication date: 2022-04-06 Open access
DOI: 10.14278/rodare.1516
Versions: 10.14278/rodare.1517
License: MIT
Downloads
Permalink: https://www.hzdr.de/publications/Publ-34492
Data publication: Caenorhabditis elegans microscopy dataset with lifespan, movement and segmentation annotations.
Galimov, E.; Pincus, Z.; Yakimovich, A.
Abstract
The nematode Caenorhabditis elegans (C. elegans) is an established model for studying various interventions into the ageing process, which allowed to find numerous genes and drugs interfering with agein. This dataset of widefield time-lapse (days 1 to 3) micrographs of C. elegans was initially obtained in the Pincus lab (Pincus et al. 2011, Zhang et al. 2016). Here, the dataset was annotated for lifespan, movement and segmentation of C. elegans, and was employed for developing a machine learning framework (Yakimovich et al. 2021). All files are in 8-bit PNG format. Movement and lifespan annotations are provided using folder structure. Segmentation annotation is provided by the accompanying masks.
Keywords: C. elegans; Caenorhabditis elegans; lifespan; movement; segmentation; microscopy
Related publications
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Caenorhabditis elegans microscopy dataset with lifespan, movement and …
ROBIS: 34213 has used this (Id 34491) publication of HZDR-primary research data
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Reseach data in external data repository
Publication year 2022
License: MIT (Link to license text)
Hosted on BioImage Archive: Link to location
Permalink: https://www.hzdr.de/publications/Publ-34491
Review on zigzag air classifier
Kaas, A.; Mütze, T.; Peuker, U. A.
Abstract
The zigzag (ZZ) classifier is a sorting and classification device with a wide range of applications (e.g. recycling, food industry [1, 2]). Due to the possible variation of geometry and process settings, the apparatus is used for various windows of operation regarding the specifications of the separation (e.g. cut sizes from 100 μm to several decimetres, compact and fluffy materials as well as foils). Since the ZZ-classifier gains more and more interest in recycling applications, it is discussed in this paper, regarding its design, mode of operation, influencing parameters and the research to date. Research on the ZZ-classifier has been going on for more than 50 years and can be divided into mainly experimental studies and modelling approaches.
Keywords: zigzag; classifier; separation; modelling; design
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Processes 10(2022)4, 764
DOI: 10.3390/pr10040764
Cited 25 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-34489
Years: 2023 2022 2021 2020 2019 2018 2017 2016 2015
Pages: [1.] [2.] [3.] [4.] [5.] [6.] [7.] [8.] [9.] [10.] [11.] [12.] [13.] [14.] [15.] [16.] [17.] [18.] [19.] [20.] [21.] [22.] [23.] [24.] [25.] [26.] [27.] [28.] [29.] [30.] [31.] [32.] [33.] [34.] [35.] [36.] [37.] [38.] [39.] [40.] [41.] [42.] [43.] [44.] [45.] [46.] [47.] [48.] [49.] [50.] [51.] [52.] [53.] [54.] [55.] [56.] [57.] [58.] [59.] [60.] [61.] [62.] [63.] [64.] [65.] [66.] [67.] [68.] [69.] [70.] [71.] [72.] [73.] [74.] [75.] [76.] [77.] [78.] [79.] [80.] [81.] [82.] [83.] [84.] [85.] [86.] [87.] [88.] [89.] [90.] [91.] [92.] [93.] [94.] [95.] [96.] [97.] [98.] [99.] [100.] [101.] [102.] [103.] [104.] [105.] [106.] [107.] [108.] [109.] [110.] [111.] [112.] [113.] [114.] [115.] [116.] [117.] [118.] [119.] [120.] [121.] [122.] [123.] [124.] [125.] [126.] [127.] [128.] [129.] [130.] [131.] [132.] [133.] [134.] [135.] [136.] [137.] [138.] [139.] [140.] [141.] [142.] [143.] [144.] [145.] [146.] [147.] [148.] [149.] [150.] [151.] [152.] [153.] [154.] [155.] [156.] [157.] [158.] [159.] [160.] [161.] [162.] [163.] [164.] [165.] [166.] [167.] [168.] [169.] [170.] [171.] [172.] [173.] [174.] [175.] [176.] [177.] [178.] [179.] [180.] [181.] [182.] [183.] [184.] [185.] [186.] [187.] [188.] [189.] [190.] [191.] [192.] [193.] [194.] [195.] [196.] [197.] [198.] [199.] [200.] [201.] [202.] [203.] [204.] [205.] [206.] [207.] [208.] [209.] [210.] [211.] [212.] [213.] [214.] [215.] [216.] [217.] [218.] [219.] [220.] [221.] [222.] [223.] [224.] [225.] [226.] [227.] [228.] [229.] [230.] [231.] [232.] [233.] [234.] [235.] [236.] [237.] [238.] [239.] [240.] [241.] [242.] [243.] [244.] [245.] [246.] [247.] [248.] [249.] [250.] [251.] [252.] [253.] [254.] [255.] [256.] [257.] [258.] [259.] [260.] [261.] [262.] [263.] [264.] [265.] [266.] [267.] [268.] [269.] [270.] [271.] [272.] [273.] [274.] [275.] [276.] [277.] [278.] [279.] [280.] [281.] [282.] [283.] [284.] [285.] [286.] [287.] [288.] [289.] [290.] [291.] [292.] [293.] [294.] [295.] [296.] [297.] [298.] [299.] [300.] [301.] [302.] [303.] [304.] [305.] [306.] [307.] [308.] [309.] [310.] [311.] [312.] [313.] [314.] [315.] [316.] [317.] [318.] [319.] [320.] [321.] [322.] [323.] [324.] [325.] [326.] [327.] [328.] [329.] [330.] [331.] [332.] [333.] [334.] [335.] [336.] [337.] [338.] [339.] [340.] [341.] [342.] [343.] [344.] [345.] [346.] [347.] [348.] [349.] [350.] [351.] [352.] [353.]