Publications of Institute of Radiopharmaceutical Cancer Research - Year 2021

Total number to be selected: 17 Records

17 Publications

2021

Leptin counteracts hypothermia in hypothyroidism through its pyrexic effects and by stabilizing serum thyroid hormone levels

Weiner, J.; Roth, L.; Kranz, M.; Brust, P.; Boelen, A.; et al. (13 authors)

Molecular Metabolism 54(2021), 101348
DOI: 10.1016/j.molmet.2021.101348

Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson's Disease

Schaffernicht, G.; Shang, Q.; Stievenard, A.; Bötzel, K.; Dening, Y.; et al. (16 authors)

Frontiers in Neurology 12(2021), 642604
DOI: 10.3389/fneur.2021.642604

Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors

Zhang, Y.; Wang, T.; Zhang, X.; Deuther-Conrad, W.; Fu, H.; et al. (10 authors)

Acta Pharmaceutica Sinica B 12(2022)3, 1406-1415
Online First (2021) DOI: 10.1016/j.apsb.2021.08.029

Development of [18F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain

Teodoro, R.; Gündel, D.; Ueberham, L.; Toussaint, M.; Bormans, G.; et al. (8 authors)

International Journal of Molecular Sciences 22(2021)15, 8051
DOI: 10.3390/ijms22158051

Development of fluorinated and methoxylated benzothiazole derivatives as highly potent and selective cannabinoid CB2 receptor ligands

Aly, M. W.; Ludwig, F.-A.; Deuther-Conrad, W.; Brust, P.; Abadi, A. H.; et al. (7 authors)Moldovan, R.-P.; Osman, N. A.

Bioorganic Chemistry 114(2021), 105191
DOI: 10.1016/j.bioorg.2021.105191

Synthesis of novel fluorinated xanthine derivatives with high adenosine A2B receptor binding affinity

Lindemann, M.; Dukic-Stefanovic, S.; Hinz, S.; Deuther-Conrad, W.; Teodoro, R.; et al. (10 authors)

Pharmaceuticals 14(2021), 485
DOI: 10.3390/ph14050485

Design, radiosynthesis and preliminary biological evaluation in mice of a brain-penetrant 18F-labelled σ2 receptor ligand

Moldovan, R.-P.; Gündel, D.; Teodoro, R.; Ludwig, F.-A.; Fischer, S.; et al. (10 authors)

International Journal of Molecular Sciences 22(2021)11, 5447
DOI: 10.3390/ijms22115447

Challenges on cyclic nucleotide phosphodiesterases imaging with positron emission tomography: Novel radioligands and (pre-)clinical insights since 2016

Schröder, S.; Scheunemann, M.; Wenzel, B.; Brust, P.

International Journal of Molecular Sciences 22(2021)8, 3832
DOI: 10.3390/ijms22083832

Validation of an LC-MS/MS method to quantify the new TRPC6 inhibitor SH045 (larixyl N-methylcarbamate) and its application in an exploratory pharmacokinetic study in mice

Chai, X.-N.; Ludwig, F.-A.; Müglitz, A.; Schaefer, M.; Yin, H.-Y.; et al. (8 authors)Brust, P.; Regenthal, R.; Krügel, U.

Pharmaceuticals 14(2021), 259
DOI: 10.3390/ph14030259

Preclinical evaluation of [¹⁸F]FACH in healthy mice and piglets: An ¹⁸F-labeled ligand for imaging of monocarboxylate transporters with PET

Gündel, D.; Sadeghzadeh, M.; Deuther-Conrad, W.; Wenzel, B.; Cumming, P.; et al. (13 authors)

International Journal of Molecular Sciences 22(2021)4, 1645
DOI: 10.3390/ijms22041645
ISSN: 1422-0067

Synthesis and biological evaluation of a novel 18F-labeled radiotracer for PET imaging of the adenosine A2A receptor

Lai, T. H.; Toussaint, M.; Teodoro, R.; Dukic-Stefanovic, S.; Kranz, M.; et al. (8 authors)

International Journal of Molecular Sciences 22(2021)3, 1182
DOI: 10.3390/ijms22031182

Development of 18F-labeled radiotracers for PET imaging of the adenosine A2A receptor: Synthesis, radiolabeling and preliminary biological evaluation

Lai, T. H.; Schröder, S.; Toussaint, M.; Dukic-Stefanovic, S.; Kranz, M.; et al. (11 authors)

International Journal of Molecular Sciences 22(2021)5, 2285
DOI: 10.3390/ijms22052285

Improved in vivo PET imaging of the adenosine A2A receptor in the brain using [18F]FLUDA, a deuterated radiotracer with high metabolic stability

Lai, T. H.; Toussaint, M.; Teodoro, R.; Dukic-Stefanovic, S.; Gündel, D.; et al. (14 authors)

European Journal of Nuclear Medicine and Molecular Imaging 48(2021), 2727-2736
DOI: 10.1007/s00259-020-05164-4

In vitro and in vivo evaluation of fluorinated indanone derivatives as potential positron emission tomography agents for the imaging of monoamine oxidase B in the brain

Dukic-Stefanovic, S.; Lai, T. H.; Toussaint, M.; Clauß, O.; Jevtić, I. I.; et al. (13 authors)

Bioorganic & Medicinal Chemistry Letters 48(2021), 128254
DOI: 10.1016/j.bmcl.2021.128254

Studies on the affinity of 6-[(: N -(cyclo)aminoalkyl)oxy]-4 H -chromen-4-ones for sigma 1/2 receptors

Deuther-Conrad, W.; Diez-Iriepa, D.; Iriepa, I.; López-Muñoz, F.; Martínez-Grau, A. M.; et al. (7 authors)Gütschow, M.; Marco-Contelles, J.

RSC Medicinal Chemistry 12(2021)6, 1000-1004
DOI: 10.1039/D1MD00105A

Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study

Grachev, I.; Meyer, P.; Becker, G.; Bronzel, M.; Marsteller, D.; et al. (24 authors)

European Journal of Nuclear Medicine and Molecular Imaging 48(2021), 1103-1115
Online First (2020) DOI: 10.1007/s00259-020-05030-3

(+)-[18F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand – Results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls

Tiepolt, S.; Becker, G.-A.; Wilke, S.; Cecchin, D.; Rullmann, M.; et al. (21 authors)

European Journal of Nuclear Medicine and Molecular Imaging 48(2021), 731-746
Online First (2020) DOI: 10.1007/s00259-020-05029-w

Years: 2024 2023 2022 2021 2020 2019 2018 2017