Publications of Institute of Radiopharmaceutical Cancer Research - Year 2016
50 Publications2016
Radiomics-based differentiation of lung disease models generated by polluted air based on X-ray computed tomography data
Szigeti, K.; Szabó, T.; Korom, C.; Ilona, C.; Horváth, I.; et al. (12 authors)
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BMC Medical Imaging 16(2016), 14
DOI: 10.1186/s12880-016-0118-z
Generation of high-avidity, WT1-reactive CD8+ cytotoxic T cell clones with anti-leukemic activity by streptamer technology
Tunger, A.; Wehner, R.; von Bonin, M.; Kühn, D.; Heidenreich, F.; et al. (20 authors)
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Leukemia & Lymphoma 58(2016)5, 1246-1249
DOI: 10.1080/10428194.2016.1233538
Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells
Dickreuter, E.; Eke, I.; Krause, M.; Borgmann, K.; van Vugt, M. A.; et al. (6 authors)
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Oncogene 35(2016)11, 1353-1362
DOI: 10.1038/onc.2015.212
New insights into the pretargeting approach to image and treat tumours
Patra, M.; Zarschler, K.; Pietzsch, H.-J.; Stephan, H.; Gasser, G.
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Chemical Society Reviews 45(2016), 6415-6431
DOI: 10.1039/c5cs00784d
Targetting microglia activation in schizophrenia by minocycline treatment
Mattei, D.; Ivanov, A.; Ferrai, G.; Jordan, P.; Guneykaya, D.; et al. (16 authors)
- European Neuropsychopharmacology 26(2016), 134
Melanoma targeting with [99mTc(N)(PNP3)]-labeled α-melanocyte stimulating hormone peptide analogs: Effects of cyclization on the radiopharmaceutical properties
Carta, D.; Salvarese, N.; Morellato, N.; Gao, F.; Sihver, W.; et al. (12 authors)
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Nuclear Medicine and Biology 43(2016)12, 788-801
DOI: 10.1016/j.nucmedbio.2016.08.014
Development of a F-18-labeled Diaryl-Substituted Dihydropyrrolo[3,2,1-hi]indole as Potential Probe for Functional Imaging of Cyclooxygenase-2 with PET
Gassner, C.; Neuber, C.; Laube, M.; Bergmann, R.; Kniess, T.; et al. (6 authors)
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ChemistrySelect 1(2016), 5812-5820
DOI: 10.1002/slct.201601618
ISSN: 2365-6549
Moments-based ultrasound visual servoing: from mono to multi-plane approach
Nadeau, C.; Krupa, A.; Petr, J.; Barillot, C.
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IEEE Transactions on Robotics 32(2016)6, 1558-1564
DOI: 10.1109/TRO.2016.2604482
The asphericity of the metabolic tumour volume in NSCLC: correlation with histopathology and molecular markers
Apostolova, I.; Ego, K.; Steffen, I. G.; Buchert, R.; Wertzel, H.; et al. (14 authors)
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European Journal of Nuclear Medicine and Molecular Imaging 43(2016)13, 2360-2373
DOI: 10.1007/s00259-016-3452-z
Gelatin-based hydrogel degradation and tissue interaction in vivo: insights from multimodal preclinical imaging in immunocompetent nude mice
Tondera, C.; Ullm, S.; Krüger-Genge, A.; Jung, F.; Neffe, A. T.; et al. (10 authors)
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Theranostics 6(2016)12, 2114-2128
DOI: 10.7150/thno.16614
Evaluation of the enantiomer specific biokinetics and radiation doses of [18-F]-fluspidine – a new tracer in clinical translation for imaging of σ1 receptors
Kranz, M.; Sattler, B.; Wüst, N.; Deuther-Conrad, W.; Patt, M.; et al. (13 authors)
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Molecules 21(2016), 1164
DOI: 10.3390/molecules21091164
Synthesis and evaluation of a 18F-labeled 4-phenylpiperidine-4-carbonitrile radioligand for σ1 receptor imaging
Ye, J.; Wang, X.; Deuther-Conrad, W.; Zhang, J.; Li, J.; et al. (10 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals (2016), 332-339
DOI: 10.1002/jlcr.3408
Comparative evaluation of SUV, tumor-to-blood standard uptake ratio (SUR), and dual time point measurements for assessment of the metabolic uptake rate in FDG PET
Hofheinz, F.; van den Hoff, J.; Steffen, I. G.; Lougovski, A.; Ego, K.; et al. (7 authors)
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EJNMMI Research 6(2016), 53
DOI: 10.1186/s13550-016-0208-5
Putaminal dopamine turnover in de novo Parkinson disease predicts later motor complications
Loehle, M.; Mende, J.; Wolz, M.; Beuthien-Baumann, B.; Oehme, L.; et al. (9 authors)
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Neurology 86(2016)3, 231-240
DOI: 10.1212/WNL.0000000000002286
ISSN: 0028-3878
Switching CAR T cells on and off: A novel modular platform for retargeting of T cells to AML blasts
Cartellieri, M.; Feldmann, A.; Koristka, S.; Arndt, C.; Loff, S.; et al. (10 authors)
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Blood Cancer Journal 6(2016), e458
DOI: 10.1038/bcj.2016.61
Zwitterionic polymer-coated ultrasmall superparamagnetic iron oxide nanoparticles with low protein interaction and high biocompatibility
Pombo-García, K.; Weiss, S.; Zarschler, K.; Ang, C.-S.; Hübner, R.; et al. (12 authors)
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ChemNanoMat 2(2016)10, 959-971
DOI: 10.1002/cnma.201600233
Tos-Nos-Mos: Synthesis of different aryl sulfonate precursors for the radiosynthesis of the alpha7 nicotinic acetylcholine receptor radioligand [18F]NS14490
Rötering, S.; Scheunemann, M.; Günther, R.; Löser, R.; Hiller, A.; et al. (9 authors)
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Applied Radiation and Isotopes 114(2016), 57-62
DOI: 10.1016/j.apradiso.2016.04.028
Extracellular S100A4 affects endothelial cell integrity and stimulates transmigratory behavior of human A375 melanoma cells
Herwig, N.; Belter, B.; Pietzsch, J.
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Biochemical and Biophysical Research Communications 477(2016)4, 963-969
DOI: 10.1016/j.bbrc.2016.07.009
Radiation dosimetry of the α4β2 nicotinic receptor ligand (+)-[18F]Flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results
Kranz, M.; Sattler, B.; Tiepolt, S.; Wilke, S.; Deuther-Conrad, W.; et al. (15 authors)
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EJNMMI Physics (2016), 3-25
DOI: 10.1186/s40658-016-0160-5
Polyglycerol-Based Copper Chelators for the Transport and Release of Copper Ions in Biological Environments
Albrecht, R.; Fehse, S.; Pant, K.; Nowag, S.; Stephan, H.; et al. (7 authors)
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Macromolecular Bioscience 16(2016), 412-419
DOI: 10.1002/mabi.201500284
Direct and Auger electron-induced, single- and double-strand breaks on plasmid DNA caused by 99mTc-labeled pyrene derivatives and the effect of bonding distance
Reissig, F.; Mamat, C.; Steinbach, J.; Pietzsch, H.-J.; Freudenberg, R.; et al. (7 authors)
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PLOS ONE 10(2016)9, e0161973
DOI: 10.1371/journal.pone.0161973
Synthesis and kinetic characterisation of water-soluble fluorogenic acyl donors for transglutaminase 2
Wodtke, R.; Schramm, G.; Pietzsch, J.; Pietsch, M.; Löser, R.
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ChemBioChem 17(2016), 1263-1281
DOI: 10.1002/cbic.201600048
Novel radioligands for cyclic nucleotide phosphodiesterase imaging with positron emission tomography: An update on developments since 2012
Schröder, S.; Wenzel, B.; Deuther-Conrad, W.; Scheunemann, M.; Brust, P.
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Molecules 21(2016)5, 650
DOI: 10.3390/molecules21050650
Multimodal Somatostatin Receptor Theranostics Using [64Cu]Cu-/[177Lu]Lu-DOTA-(Tyr3)octreotate and AN-238 in a Mouse Pheochromocytoma Model.
Ullrich, M.; Bergmann, R.; Peitzsch, M.; Zenker, E.; Cartellieri, M.; et al. (13 authors)
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Theranostics 6(2016)5, 650-665
DOI: 10.7150/thno.14479
Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds
Sarasamkan, J.; Scheunemann, M.; Apaijai, N.; Palee, S.; Parichatikanond, W.; et al. (12 authors)
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ACS Medicinal Chemistry Letters 7(2016)10, 890-895
DOI: 10.1021/acsmedchemlett.6b00146
Comparison of in silico, electrochemical, in vitro and in vivo metabolism of a homologous series of (radio)fluorinated sigma1 receptor ligands designed for positron emission tomography
Wiese, C.; Große Maestrup, E.; Galla, F.; Schepmann, D.; Hiller, A.; et al. (13 authors)
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ChemMedChem 11(2016), 2445-2458
DOI: 10.1002/cmdc.201600366
Beta-Amyloid-PET-Bildgebung des Gehirns - DGN-Handlungsempfehlung
Barthel, H.; Meyer, P. T.; Drzezga, A.; Bartenstein, P.; Boecker, H.; et al. (17 authors)
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Nuklearmedizin 55(2016)4, 129-137
DOI: 10.3413/Nukmed-0816-16-04
Rational Structure-Based Rescaffolding Approach to de Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics
Ruiz-Gómez, G.; Hawkins, J. C.; Philipp, J.; Künze, G.; Wodtke, R.; et al. (8 authors)
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PLOS ONE 11(2016)4, e0154046
DOI: 10.1371/journal.pone.0154046
Development of antioxidant COX-2 inhibitors as radioprotective agents for radiation therapy – a hypothesis-driven review
Laube, M.; Kniess, T.; Pietzsch, J.
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Antioxidants 5(2016)2, 14
DOI: 10.3390/antiox5020014
99mTc-Cyclopentadienyl Tricarbonyl Chelate-Labeled Compounds as Selective Sigma‑2 Receptor Ligands for Tumor Imaging
Li, D.; Chen, Y.; Wang, X.; Deuther-Conrad, W.; Chen, X.; et al. (11 authors)
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Journal of Medicinal Chemistry 59(2016)3, 934-946
DOI: 10.1021/acs.jmedchem.5b01378
LC-MS supported Studies on the in vitro Metabolism of both Enantiomers of Flubatine and the in vivo Metabolism of (+)-[18F]Flubatine – a Positron Emission Tomography Radioligand for Imaging α4β2-Nicotinic Acetylcholine Receptors
Ludwig, F.-A.; Smits, R.; Fischer, S.; Donat, C. K.; Hoepping, A.; et al. (7 authors)
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Molecules 21(2016)9, 1200
DOI: 10.3390/molecules21091200
Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice
Weiner, J.; Kranz, M.; Klöting, N.; Kunath, A.; Steinhoff, K.; et al. (20 authors)
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Scientific Reports 6(2016), 38124
DOI: 10.1038/srep38124
Changes in Binding of [123I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury
Donat, C. K.; Gaber, K.; Meixensberger, J.; Brust, P.; Pinborg, L. H.; et al. (7 authors)
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Neuromolecular Medicine 18(2016)2, 158-169
DOI: 10.1007/s12017-016-8385-y
Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor
Moldovan, R.-P.; Teodoro, R.; Deuther-Conrad, W.; Kranz, M.; Wang, Y.; et al. (13 authors)
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Journal of Medicinal Chemistry 59(2016)17, 7840-7855
DOI: 10.1021/acs.jmedchem.6b00554
Ultrasmall inorganic nanoparticles: state-of-the-art and perspectives for biomedical applications
Zarschler, K.; Rocks, L.; Licciardello, N.; Boselli, L.; Polo, E.; et al. (9 authors)
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Nanomedicine: Nanotechnology, Biology, and Medicine 12(2016)6, 1663-1701
DOI: 10.1016/j.nano.2016.02.019
An investigation of the relation between tumor-to-liver ratio (TLR) and tumor-to-blood standard uptake ratio (SUR) in oncological FDG PET.
Hofheinz, F.; Bütof, R.; Apostolova, I.; Zöphel, K.; Steffen, I. G.; et al. (9 authors)
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EJNMMI Research 6(2016)1, 19
DOI: 10.1186/s13550-016-0174-y
Early and late effects of radiochemotherapy on cerebral blood flow in glioblastoma patients measured with non-invasive perfusion MRI
Petr, J.; Platzek, I.; Seidlitz, A.; Mutsaerts, H. J. M. M.; Hofheinz, F.; et al. (10 authors)
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Radiotherapy and Oncology 118(2016)1, 24-28
Online First (2015) DOI: 10.1016/j.radonc.2015.12.017
5-Chloro-1-phenylpentan-1-one
Bechmann, N.; Kniess, T.; Pietzsch, J.; König, J.; Köckerling, M.
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IUCrData 1(2016), 160055
DOI: 10.1107/S2414314616000559
ISSN: 2414-3146
Development of a new radiofluorinated quinoline analog for PET imaging of phosphodiesterase 5 (PDE5) in brain.
Liu, J.; Wenzel, B.; Dukic-Stefanovic, S.; Teodoro, R.; Ludwig, F.-A.; et al. (11 authors)
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Pharmaceuticals 9(2016)2, 22
DOI: 10.3390/ph9020022
ISSN: 1424-8247
Synthesis, dynamic NMR characterization and XRD studies of novel N,N’-substituted piperazines for bioorthogonal labeling
Mamat, C.; Pretze, M.; Gott, M.; Köckerling, M.
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Beilstein Journal of Organic Chemistry 12(2016), 2479-2489
DOI: 10.3762/bjoc.12.242
The Radiochemical and radiopharmaceutical applications of radium
Gott, M.; Steinbach, J.; Mamat, C.
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Open Chemistry 14(2016), 118-129
DOI: 10.1515/chem-2016-0011
177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment
Bergmann, R.; Meckel, M.; Kubicek, V.; Pietzsch, J.; Steinbach, J.; et al. (7 authors)
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EJNMMI Research 6(2016)1, 5
DOI: 10.1186/s13550-016-0161-3
Radiopharmacological characterization of 64Cu-labeled α-MSH analogs for potential use in imaging of malignant melanoma
Gao, F.; Sihver, W.; Jurischka, C.; Bergmann, R.; Haase-Kohn, C.; et al. (12 authors)
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Amino Acids 48(2016)3, 833-847
Online First (2015) DOI: 10.1007/s00726-015-2131-x
Characterization of the microbunch time structure of proton pencil beams at a clinical treatment facility
Petzoldt, J.; Römer, K. E.; Enghardt, W.; Fiedler, F.; Golnik, C.; et al. (12 authors)
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Physics in Medicine and Biology 61(2016)6, 2432-2456
DOI: 10.1088/0031-9155/61/6/2432
PET imaging evaluation of [18F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates
Hillmer, A. T.; Zheng, M.-Q.; Li, S.; Scheunemann, M.; Lin, S.-F.; et al. (13 authors)
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European Journal of Nuclear Medicine and Molecular Imaging 43(2016)3, 537-547
Online First (2015) DOI: 10.1007/s00259-015-3209-0
A novel thermoregulatory role for PDE10A in mouse and human adipocytes
Hankir, M.; Kranz, M.; Gnad, T.; Wagner, S.; Deuther-Conrad, W.; et al. (16 authors)
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EMBO Molecular Medicine 8(2016), 796-812
DOI: 10.15252/emmm.201506085
ISSN: 0021-9738
Interaction of extracellular S100A4 with RAGE prompts prometastatic activation of A375 melanoma cells
Herwig, N.; Belter, B.; Wolf, S.; Haase-Kohn, C.; Pietzsch, J.
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Journal of Cellular and Molecular Medicine 20(2016)5, 825-835
DOI: 10.1111/jcmm.12808
Development of highly potent phosphodiesterase 10A (PDE10A) inhibitors: Synthesis and in vitro evaluation of 1,8-dipyridyl- and 1-pyridinol-substituted imidazo[1,5-a]quinoxalines
Wagner, S.; Scheunemann, M.; Dipper, K.; Egerland, U.; Hoefgen, N.; et al. (7 authors)
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European Journal of Medicinal Chemistry 107(2016), 97-108
DOI: 10.1016/j.ejmech.2015.10.028
On the development of a novel non-peptidic 18F-labeled radiotracer for in vivo imaging of oxytocin receptors with positron emission tomography
Wenzel, B.; Mollitor, J.; Deuther-Conrad, W.; Kranz, M.; Dukic-Stefanovic, S.; et al. (13 authors)
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Journal of Medicinal Chemistry 59(2016)5, 1800-1817
DOI: 10.1021/acs.jmedchem.5b01080
ISSN: 0022-2623
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