Publications of Institute of Radiopharmaceutical Cancer Research - Year 2019

66 Publications

2019

Correlation between FMISO-PET based hypoxia in the primary tumour and in lymph node metastases in locally advanced HNSCC patients

Bandurska-Luque, A.; Löck, S.; Haase, R.; Richter, C.; Zöphel, K.; et al. (14 authors)

The Evolving Landscape of Biomarkers for Anti-PD-1 or Anti-PD-L1 Therapy

Tunger, A.; Sommer, U.; Wehner, R.; Kubasch, A. S.; Grimm, M.-O.; et al. (10 authors)

Confirmation of the prognostic value of pretherapeutic tumor SUR and MTV in patients with esophageal squamous cell carcinoma

Hofheinz, F.; Li, Y.; Steffen, I.; Lin, Q.; Lili, C.; et al. (8 authors)

Introduction of the New Center for Radiopharmaceutical Cancer Research at Helmholtz-Zentrum Dresden-Rossendorf

Kreller, M.; Pietzsch, H.-J.; Walther, M.; Tietze, H.; Kaever, P.; et al. (9 authors)

Comparison of Static and Dynamic 18F-FDG PET/CT for Quantification of Pulmonary Inflammation in Acute Lung Injury

Braune, A.; Hofheinz, F.; Bluth, T.; Kiss, T.; Wittenstein, J.; et al. (8 authors)

Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine- based Radioligand for Imaging of Phosphodiesterase 2A with Positron Emission Tomography

Ritawidya, R.; Wenzel, B.; Teodoro, R.; Toussaint, M.; Kranz, M.; et al. (10 authors)

Synthesis and cyclooxygenase inhibition of sulfonamide-substituted (dihydro)pyrrolo[3,2,1-hi]indoles and their potential prodrugs

Laube, M.; Gassner, C.; Knieß, T.; Pietzsch, J.

Characterization of Tissue Transglutaminase as a Potential Biomarker for Tissue Response toward Biomaterials

Hauser, S.; Wodtke, R.; Tondera, C.; Wodtke, J.; Neffe, A. T.; et al. (9 authors)

Synthesis, Structural Characterisation, and Cytotoxicity Studies of Bi, W, and Mo containing Homo- and Hetero-bimetallic Polyoxometalates

Senevirathna, D.; Werrett, M.; Kubeil, M.; Stephan, H.; Andrews, P.

Current management of pheochromocytoma/paraganglioma: A guide for the practicing clinician in the era of precision medicine

Nölting, S.; Ullrich, M.; Pietzsch, J.; Ziegler, C. G.; Eisenhofer, G.; et al. (7 authors)

Conventional CARs versus modular CARs

Feldmann, A.; Arndt, C.; Koristka, S.; Berndt, N.; Bergmann, R.; et al. (6 authors)

A comparative evaluation of calix[4]arene-1,3-crown-6 as a ligand for selected divalent cations of radiopharmaceutical interest

Bauer, D.; Blumberg, M.; Köckerling, M.; Mamat, C.

One-step radiosynthesis of the MCTs imaging agent [18F]FACH by aliphatic 18F-labelling of a methylsulfonate precursor containing an unprotected carboxylic acid group

Sadeghzadeh, M.; Moldovan, R.-P.; Teodoro, R.; Brust, P.; Wenzel, B.

A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR

Arndt, C.; Feldmann, A.; Koristka, S.; Schäfer, M.; Bergmann, R.; et al. (19 authors)

Biomaterials in repairing rat femoral defects: in vivo insights from small animal positron emission tomography/computed tomography (PET/CT) studies

Neuber, C.; Schulze, S.; Förster, Y.; Hofheinz, F.; Wodke, J.; et al. (11 authors)

  • Open Access Logo Clinical Hemorheology and Microcirculation 73(2019), 177-194
    DOI: 10.3233/CH-199208

Structure–Affinity Relationships of Fluorinated Spirocyclic Sigma2 Receptor Ligands with an Exocyclic Benzylamino Moiety

Bergkemper, M.; Kronenberg, E.; Schepmann, D.; Ludwig, F.-A.; Brust, P.; et al. (6 authors)

¹⁸F-Labeled benzylpiperazine derivatives as highly selective ligands for imaging σ1 receptor with positron emission tomography

Ye, J.; Wang, L.; Deuther-Conrad, W.; Chen, Y.; Zhang, X.; et al. (9 authors)

  • Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 425-437
    DOI: 10.1002/jlcr.3738

Theranostic CAR T cell targeting: A brief review

Arndt, C.; Bachmann, M.; Bergmann, R.; Berndt, N.; Feldmann, A.; et al. (6 authors)

  • Open Access Logo Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 533-540
    DOI: 10.1002/jlcr.3727

Dual-time-point 64Cu-PSMA-617-PET/CT in patients suffering from prostate cancer

Hoberück, S.; Wunderlich, G.; Michler, E.; Hölscher, T.; Walther, M.; et al. (9 authors)

  • Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 523-532
    DOI: 10.1002/jlcr.3745

Tetranuclear Cu(II)-chiral complexes: Synthesis, characterization and biological activity

Peewasan, K.; Merkel, M. P.; Zarschler, K.; Stephan, H.; Anson, C. E.; et al. (6 authors)

The association of intra-therapeutic heterogeneity of somatostatin receptor expression with morphological treatment response in patients undergoing PRRT with [177Lu]-DOTATATE

Wetz, C.; Genseke, P.; Apostolova, I.; Furth, C.; Ghazzawi, S.; et al. (11 authors)

Instant kit preparation of 68Ga-radiopharmaceuticals via the hybrid chelator DATA: clinical translation of [68Ga]Ga-DATA-TOC

Sinnes, J. P.; Nagel, J.; Waldron, B. P.; Maina, T.; Nock, B. A.; et al. (11 authors)

Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network

Xu, Y.; Patsis, P. A.; Hauser, S.; Voigt, D.; Rothe, R.; et al. (15 authors)

Editorial for special issue "Jörg Steinbach"

Mamat, C.

  • Open Access Logo Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 350-351
    DOI: 10.1002/jlcr.3773

T cells engrafted with a UniCAR 28/ζ outperform UniCAR BB/ζ-transduced T cells in the face of regulatory T cell-mediated immunosuppression

Kegler, A.; Koristka, S.; Bergmann, R.; Berndt, N.; Arndt, C.; et al. (10 authors)

Nitric oxide-releasing selective estrogen receptor modulators (NO-SERMs): a bifunctional approach to improve the therapeutic index

Bechmann, N.; Knieß, T.; Pietzsch, J.

Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background

Ullrich, M.; Richter, S.; Seifert, V.; Hauser, S.; Calsina, B.; et al. (12 authors)

Synthesis and in vitro evaluation of 8-pyridinyl substituted benzo[e]imidazo[2,1-c][1,2,4]triazines as phosphodiesterase 2A (PDE2A) inhibitors

Ritawidya, R.; Ludwig, F.-A.; Briel, D.; Brust, P.; Scheunemann, M.

Adjuvant drug-assisted bone healing: Part III – Further strategies for local and systemic modulation

Rothe, R.; Schulze, S.; Neuber, C.; Hauser, S.; Rammelt, S.; et al. (6 authors)

  • Clinical Hemorheology and Microcirculation 73(2019), 439-488
    DOI: 10.3233/CH-199104
    ISSN: 1386-0291

Adjuvant drug-assisted bone healing: Part II – Modulation of angiogenesis

Rothe, R.; Schulze, S.; Neuber, C.; Hauser, S.; Rammelt, S.; et al. (6 authors)

  • Open Access Logo Clinical Hemorheology and Microcirculation 73(2019), 409-438
    DOI: 10.3233/CH-199103
    ISSN: 1386-0291

Adjuvant drug-assisted bone healing: Part I – Modulation of inflammation

Rothe, R.; Schulze, S.; Neuber, C.; Hauser, S.; Rammelt, S.; et al. (6 authors)

  • Clinical Hemorheology and Microcirculation 73(2019), 381-408
    DOI: 10.3233/CH-199102
    ISSN: 1386-0291

The UniCAR system: A modular CAR T cell approach to improve the safety of CAR T cells

Bachmann, M.

Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells

Bechmann, N.; Poser, I.; Seifert, V.; Greunke, C.; Ullrich, M.; et al. (13 authors)

Carboranyl analogues of ketoprofen with cytostatic activity against human melanoma and colon cancer cell lines

Buzharevski, A.; Paskas, S.; Laube, M.; Lönnecke, P.; Neumann, W.; et al. (10 authors)

Midostaurin abrogates CD33-directed UniCAR and CD33-CD3 bispecific antibody therapy in acute myeloid leukemia

Fasslrinner, F.; Arndt, C.; Koristka, S.; Feldmann, A.; Altmann, H.; et al. (9 authors)

An oligo-His-tag of a targeting module does not influence its biodistribution and the retargeting capabilities of UniCAR T cells

Jureczek, J.; Bergmann, R.; Berndt, N.; Koristka, S.; Kegler, A.; et al. (10 authors)

Late life brain perfusion after prenatal famine exposure

de Rooij, S. R.; Mutsaerts, H. M.; Petr, J.; Asllani, I.; Caan, M. W.; et al. (9 authors)

A 224Ra-labeled polyoxopalladate as putative radiopharmaceutical

Gott, M.; Yang, P.; Kortz, U.; Stephan, H.; Pietzsch, H.-J.; et al. (6 authors)

Interobserver variability of image-derived arterial blood SUV in whole-body FDG PET

Hofheinz, F.; Maus, J.; Zschaeck, S.; Rogasch, J.; Schramm, G.; et al. (9 authors)

Time efficient scatter correction for time-of-flight PET: the immediate scatter approximation

Nikulin, P.; Maus, J.; Hofheinz, F.; Lougovski, A.; van den Hoff, J.

SPECT-Untersuchungen mit dem 123 I-markierten Dopamintransporter-Liganden FP-CIT (DaTSCAN):DGN-Handlungsempfehlung (S1-Leitlinie)

Tatsch, K.; Buchert, R.; Bartenstein, P.; Barthel, H.; Boecker, H.; et al. (17 authors)

  • Nuklearmedizin 58(2019)1, 5-16

In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine – a Radioligand for Imaging σ1 Receptors with Positron Emission Tomography (PET)

Ludwig, F.-A.; Fischer, S.; Houska, R.; Hoepping, A.; Deuther-Conrad, W.; et al. (15 authors)

Limited importance of EphrinA1–ligand, Src kinase, and focal adhesion kinase in EphA2-mediated regulation of metastasis in Mel-Juso and A375 human melanoma cells

Neuber, C.; Herwig, N.; Pietzsch, J.; Belter, B.

  • Journal of Cellular Biotechnology 5(2019)1, 11-26
    DOI: 10.3233/JCB-189010
    ISSN: 2352-3689

Regulation of A375 melanoma cell adhesion and migration by EphB4 and EphrinB2 –insights from co-culture experiments

Neuber, C.; Laube, M.; Mamat, C.; Belter, B.; Pietzsch, J.

  • Journal of Cellular Biotechnology 5(2019)1, 27-42
    DOI: 10.3233/JCB-189011
    ISSN: 2352-3689

Radiochemical and radiopharmacological characterization of a 64Cu-labeled α-MSH analog conjugated with different chelators

Gao, F.; Sihver, W.; Bergmann, R.; Walther, M.; Stephan, H.; et al. (11 authors)

  • Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 495-509
    DOI: 10.1002/jlcr.3728

Fluorescent Mouse Pheochromocytoma Spheroids Expressing Hypoxia-Inducible Factor 2 alpha: Morphologic and Radiopharmacologic Characterization

Seifert, V.; Liers, J.; Kniess, T.; Richter, S.; Bechmann, N.; et al. (10 authors)

  • Journal of Cellular Biotechnology 5(2019)2, 135-151
    DOI: 10.3233/JCB-199005
    ISSN: 2352-3689

Facile preparation of radium-doped, functionalized nanoparticles as carriers for targeted alpha therapy

Reissig, F.; Hübner, R.; Steinbach, J.; Pietzsch, H.-J.; Mamat, C.

Carboranyl Analogues of Celecoxib with Potent Cytostatic Activity against Human Melanoma and Colon Cancer Cell Lines

Buzharevski, A.; Paskas, S.; Sárosi, M. B.; Laube, M.; Lönnecke, P.; et al. (10 authors)

Fluorine-18 labeling of S100 proteins for small animal positron emission tomography

Laube, M.; Kniess, T.; Neuber, C.; Haase-Kohn, C.; Pietzsch, J.

Development and radiosynthesis of the first 18F-labeled inhibitor of monocarboxylate transporters (MCTs)

Sadeghzadeh, M.; Moldovan, R.-P.; Fischer, S.; Wenzel, B.; Ludwig, F.-A.; et al. (14 authors)

  • Open Access Logo Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 411-424
    DOI: 10.1002/jlcr.3739

FDG-PET/MRI in patients with pelvic recurrence of rectal cancer: first clinical experiences

Plodeck, V.; Rahbari, N.; Weitz, J.; Radosa, C.; Laniado, M.; et al. (11 authors)

Synthesis, Structural Characterization and Photodecarbonylation Study of a Dicarbonyl Ruthenium(II)-Bisquinoline Complex

Kubeil, M.; Joshi, T.; Wood, B. R.; Stephan, H.

Synthesis and preliminary radiopharmacological characterisation of an 11C-labelled azadipeptide nitrile as potential PET tracer for imaging of cysteine cathepsins

Laube, M.; Frizler, M.; Wodtke, R.; Neuber, C.; Belter, B.; et al. (10 authors)

  • Open Access Logo Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 448-459
    DOI: 10.1002/jlcr.3729

Tarnkappen-Technologie für leuchtende Nanopartikeln

Stephan, H.; Zarschler, K.

  • Open Access Logo GIT Labor-Fachzeitschrift (2019)8, 55-57

Tonic signaling and its effects on lymphopoiesis of CAR-armed hematopoietic stem and progenitor cells

Albert, S.; Koristka, S.; Gerbaulet, A.; Cartellieri, M.; Arndt, C.; et al. (15 authors)

Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study

Mutsaerts, H. J. M. M.; Mirza, S. S.; Petr, J.; Thomas, D. L.; Cash, D. M.; et al. (31 authors)

Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18

Wenzel, B.; Liu, J.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Teodoro, R.; et al. (10 authors)

Synthesis, 18F-labelling and radiopharmacological characterisation of the C-terminal 30mer of Clostridium perfringens enterotoxin as a potential claudin-targeting peptide

Löser, R.; Bader, M.; Kuchar, M.; Wodtke, R.; Lenk, J.; et al. (12 authors)

Neoadjuvant radiochemotherapy significantly alters the phenotype of plasmacytoid dendritic cells and 6-sulfo LacNAc+ monocytes in rectal cancer

Wagner, F.; Hölig, U.; Wilczkowski, F.; Sommer, U.; Wehner, R.; et al. (23 authors)

Cathepsin B: Active Site Mapping with Peptidic Substrates and Inhibitors

Schmitz, J.; Gilberg, E.; Löser, R.; Bajorath, J.; Bartz, U.; et al. (6 authors)

One-pot Cascade Synthesis of Pyrazole-based Isosteres of Valdecoxib by a [3+2] Cycloaddition/[1,5] Sigmatropic Rearrangement Sequence and Evaluation of their COX Inhibitory Activity

Roscales, S.; Bechmann, N.; Pietzsch, J.; Kniess, T.

Anti-CAR engineered T cells for epitope-based elimination of autologous CAR T cells

Koristka, S.; Ziller-Walter, P.; Bergmann, R.; Arndt, C.; Feldmann, A.; et al. (11 authors)

Access to 18F-labelled isoxazoles by Ruthenium-promoted 1,3-dipolar cycloaddition of 4-[18F]fluoro-N-hydroxybenzimidoyl chloride with alkynes.

Roscales, S.; Kniess, T.

  • Open Access Logo Journal of Labelled Compounds and Radiopharmaceuticals 62(2019), 393-403
    DOI: 10.1002/jlcr.3708

Expression of Glypican-3 is an Independent Prognostic Biomarker in Primary Gastro-Esophageal Adenocarcinoma and Corresponding Serum Exosomes

Rahbari, M.; Pecqueux, M.; Aust, D.; Stephan, H.; Tiebel, O.; et al. (14 authors)

Prognostic value of SUR in patients with trimodality treatment of locally advanced esophageal carcinoma

Bütof, R.; Hofheinz, F.; Zöphel, K.; Schmollack, J.; Jentsch, C.; et al. (9 authors)

Studies towards the development of a PET radiotracer for imaging of the P2Y1 receptors in the brain: synthesis, 18F-labeling and preliminary biological evaluation

Moldovan, R.-P.; Wenzel, B.; Teodoro, R.; Neumann, W.; Dukic-Stefanovic, S.; et al. (9 authors)

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