Publications of Institute of Radiopharmaceutical Cancer Research - Year 2019
66 Publications2019
Correlation between FMISO-PET based hypoxia in the primary tumour and in lymph node metastases in locally advanced HNSCC patients
Bandurska-Luque, A.; Löck, S.; Haase, R.; Richter, C.; Zöphel, K.; et al. (14 authors)
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Clinical and Translational Radiation Oncology 15(2019), 108-112
DOI: 10.1016/j.ctro.2019.02.002
The Evolving Landscape of Biomarkers for Anti-PD-1 or Anti-PD-L1 Therapy
Tunger, A.; Sommer, U.; Wehner, R.; Kubasch, A. S.; Grimm, M.-O.; et al. (10 authors)
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Journal of Clinical Medicine 8(2019)10, 1534
DOI: 10.3390/jcm8101534
Confirmation of the prognostic value of pretherapeutic tumor SUR and MTV in patients with esophageal squamous cell carcinoma
Hofheinz, F.; Li, Y.; Steffen, I.; Lin, Q.; Lili, C.; et al. (8 authors)
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European Journal of Nuclear Medicine and Molecular Imaging 46(2019), 1485-1494
DOI: 10.1007/s00259-019-04307-6
Introduction of the New Center for Radiopharmaceutical Cancer Research at Helmholtz-Zentrum Dresden-Rossendorf
Kreller, M.; Pietzsch, H.-J.; Walther, M.; Tietze, H.; Kaever, P.; et al. (9 authors)
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Instruments 3(2019)1, 9
DOI: 10.3390/instruments3010009
Comparison of Static and Dynamic 18F-FDG PET/CT for Quantification of Pulmonary Inflammation in Acute Lung Injury
Braune, A.; Hofheinz, F.; Bluth, T.; Kiss, T.; Wittenstein, J.; et al. (8 authors)
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Journal of Nuclear Medicine 60(2019)11, 1629-1634
DOI: 10.2967/jnumed.119.226597
Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine- based Radioligand for Imaging of Phosphodiesterase 2A with Positron Emission Tomography
Ritawidya, R.; Wenzel, B.; Teodoro, R.; Toussaint, M.; Kranz, M.; et al. (10 authors)
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Molecules 24(2019)22, 4149
DOI: 10.3390/molecules24224149
Synthesis and cyclooxygenase inhibition of sulfonamide-substituted (dihydro)pyrrolo[3,2,1-hi]indoles and their potential prodrugs
Laube, M.; Gassner, C.; Knieß, T.; Pietzsch, J.
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Molecules 24(2019), 3807
DOI: 10.3390/molecules24203807
Characterization of Tissue Transglutaminase as a Potential Biomarker for Tissue Response toward Biomaterials
Hauser, S.; Wodtke, R.; Tondera, C.; Wodtke, J.; Neffe, A. T.; et al. (9 authors)
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ACS Biomaterials Science & Engineering 5(2019), 5979-5989
DOI: 10.1021/acsbiomaterials.9b01299
ISSN: 2373-9878
Synthesis, Structural Characterisation, and Cytotoxicity Studies of Bi, W, and Mo containing Homo- and Hetero-bimetallic Polyoxometalates
Senevirathna, D.; Werrett, M.; Kubeil, M.; Stephan, H.; Andrews, P.
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Dalton Transactions 48(2019), 15962-15969
DOI: 10.1039/C9DT03288F
Current management of pheochromocytoma/paraganglioma: A guide for the practicing clinician in the era of precision medicine
Nölting, S.; Ullrich, M.; Pietzsch, J.; Ziegler, C. G.; Eisenhofer, G.; et al. (7 authors)
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Cancers 11(2019), 1505
DOI: 10.3390/cancers11101505
ISSN: 2072-6694
Conventional CARs versus modular CARs
Feldmann, A.; Arndt, C.; Koristka, S.; Berndt, N.; Bergmann, R.; et al. (6 authors)
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Cancer Immunology, Immunotherapy 68(2019)10, 1713-1719
DOI: 10.1007/s00262-019-02399-5
A comparative evaluation of calix[4]arene-1,3-crown-6 as a ligand for selected divalent cations of radiopharmaceutical interest
Bauer, D.; Blumberg, M.; Köckerling, M.; Mamat, C.
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RSC Advances 7(2019)55, 32357-32366
DOI: 10.1039/C9RA07293D
One-step radiosynthesis of the MCTs imaging agent [18F]FACH by aliphatic 18F-labelling of a methylsulfonate precursor containing an unprotected carboxylic acid group
Sadeghzadeh, M.; Moldovan, R.-P.; Teodoro, R.; Brust, P.; Wenzel, B.
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Scientific Reports 9(2019), 18890
DOI: 10.1038/s41598-019-55354-w
A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR
Arndt, C.; Feldmann, A.; Koristka, S.; Schäfer, M.; Bergmann, R.; et al. (19 authors)
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OncoImmunology 8(2019)9, 1659095
DOI: 10.1080/2162402X.2019.1659095
Biomaterials in repairing rat femoral defects: in vivo insights from small animal positron emission tomography/computed tomography (PET/CT) studies
Neuber, C.; Schulze, S.; Förster, Y.; Hofheinz, F.; Wodke, J.; et al. (11 authors)
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Clinical Hemorheology and Microcirculation 73(2019), 177-194
DOI: 10.3233/CH-199208
Structure–Affinity Relationships of Fluorinated Spirocyclic Sigma2 Receptor Ligands with an Exocyclic Benzylamino Moiety
Bergkemper, M.; Kronenberg, E.; Schepmann, D.; Ludwig, F.-A.; Brust, P.; et al. (6 authors)
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ChemMedChem 14(2019), 1392-1402
DOI: 10.1002/cmdc.201900284
¹⁸F-Labeled benzylpiperazine derivatives as highly selective ligands for imaging σ1 receptor with positron emission tomography
Ye, J.; Wang, L.; Deuther-Conrad, W.; Chen, Y.; Zhang, X.; et al. (9 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 425-437
DOI: 10.1002/jlcr.3738
Theranostic CAR T cell targeting: A brief review
Arndt, C.; Bachmann, M.; Bergmann, R.; Berndt, N.; Feldmann, A.; et al. (6 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 533-540
DOI: 10.1002/jlcr.3727
Dual-time-point 64Cu-PSMA-617-PET/CT in patients suffering from prostate cancer
Hoberück, S.; Wunderlich, G.; Michler, E.; Hölscher, T.; Walther, M.; et al. (9 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 523-532
DOI: 10.1002/jlcr.3745
Tetranuclear Cu(II)-chiral complexes: Synthesis, characterization and biological activity
Peewasan, K.; Merkel, M. P.; Zarschler, K.; Stephan, H.; Anson, C. E.; et al. (6 authors)
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RSC Advances 9(2019)42, 24087-24091
DOI: 10.1039/c9ra03586a
The association of intra-therapeutic heterogeneity of somatostatin receptor expression with morphological treatment response in patients undergoing PRRT with [177Lu]-DOTATATE
Wetz, C.; Genseke, P.; Apostolova, I.; Furth, C.; Ghazzawi, S.; et al. (11 authors)
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PLOS ONE 14(2019)5, e0216781
DOI: 10.1371/journal.pone.0216781
Instant kit preparation of 68Ga-radiopharmaceuticals via the hybrid chelator DATA: clinical translation of [68Ga]Ga-DATA-TOC
Sinnes, J. P.; Nagel, J.; Waldron, B. P.; Maina, T.; Nock, B. A.; et al. (11 authors)
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EJNMMI Research 9(2019), 48
DOI: 10.1186/s13550-019-0516-7
Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network
Xu, Y.; Patsis, P. A.; Hauser, S.; Voigt, D.; Rothe, R.; et al. (15 authors)
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Advanced Science 6(2019), 1802077
DOI: 10.1002/advs.201802077
Editorial for special issue "Jörg Steinbach"
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 350-351
DOI: 10.1002/jlcr.3773
T cells engrafted with a UniCAR 28/ζ outperform UniCAR BB/ζ-transduced T cells in the face of regulatory T cell-mediated immunosuppression
Kegler, A.; Koristka, S.; Bergmann, R.; Berndt, N.; Arndt, C.; et al. (10 authors)
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OncoImmunology 8(2019)9, e1621676
DOI: 10.1080/2162402X.2019.1621676
Nitric oxide-releasing selective estrogen receptor modulators (NO-SERMs): a bifunctional approach to improve the therapeutic index
Bechmann, N.; Knieß, T.; Pietzsch, J.
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Journal of Medicinal Chemistry 62(2019), 6525-6539
DOI: 10.1021/acs.jmedchem.9b00171
ISSN: 0022-2623
Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background
Ullrich, M.; Richter, S.; Seifert, V.; Hauser, S.; Calsina, B.; et al. (12 authors)
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Cancers 11(2019), 743
DOI: 10.3390/cancers11060743
ISSN: 2072-6694
Synthesis and in vitro evaluation of 8-pyridinyl substituted benzo[e]imidazo[2,1-c][1,2,4]triazines as phosphodiesterase 2A (PDE2A) inhibitors
Ritawidya, R.; Ludwig, F.-A.; Briel, D.; Brust, P.; Scheunemann, M.
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Molecules 24(2019)15, 2791
DOI: 10.3390/molecules24152791
Adjuvant drug-assisted bone healing: Part III – Further strategies for local and systemic modulation
Rothe, R.; Schulze, S.; Neuber, C.; Hauser, S.; Rammelt, S.; et al. (6 authors)
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Clinical Hemorheology and Microcirculation 73(2019), 439-488
DOI: 10.3233/CH-199104
ISSN: 1386-0291
Adjuvant drug-assisted bone healing: Part II – Modulation of angiogenesis
Rothe, R.; Schulze, S.; Neuber, C.; Hauser, S.; Rammelt, S.; et al. (6 authors)
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Clinical Hemorheology and Microcirculation 73(2019), 409-438
DOI: 10.3233/CH-199103
ISSN: 1386-0291
Adjuvant drug-assisted bone healing: Part I – Modulation of inflammation
Rothe, R.; Schulze, S.; Neuber, C.; Hauser, S.; Rammelt, S.; et al. (6 authors)
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Clinical Hemorheology and Microcirculation 73(2019), 381-408
DOI: 10.3233/CH-199102
ISSN: 1386-0291
The UniCAR system: A modular CAR T cell approach to improve the safety of CAR T cells
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Immunology Letters 211(2019), 13-22
DOI: 10.1016/j.imlet.2019.05.003
Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells
Bechmann, N.; Poser, I.; Seifert, V.; Greunke, C.; Ullrich, M.; et al. (13 authors)
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Cancers 11(2019), 594
DOI: 10.3390/cancers11050594
ISSN: 2072-6694
Carboranyl analogues of ketoprofen with cytostatic activity against human melanoma and colon cancer cell lines
Buzharevski, A.; Paskas, S.; Laube, M.; Lönnecke, P.; Neumann, W.; et al. (10 authors)
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ACS Omega 4(2019)5, 8824-8833
DOI: 10.1021/acsomega.9b00412
Midostaurin abrogates CD33-directed UniCAR and CD33-CD3 bispecific antibody therapy in acute myeloid leukemia
Fasslrinner, F.; Arndt, C.; Koristka, S.; Feldmann, A.; Altmann, H.; et al. (9 authors)
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British Journal of Haematology 186(2019)5, 735-740
DOI: 10.1111/bjh.15975
An oligo-His-tag of a targeting module does not influence its biodistribution and the retargeting capabilities of UniCAR T cells
Jureczek, J.; Bergmann, R.; Berndt, N.; Koristka, S.; Kegler, A.; et al. (10 authors)
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Scientific Reports 9(2019)1, 10547
DOI: 10.1038/s41598-019-47044-4
Late life brain perfusion after prenatal famine exposure
de Rooij, S. R.; Mutsaerts, H. M.; Petr, J.; Asllani, I.; Caan, M. W.; et al. (9 authors)
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Neurobiology of Aging 82(2019), 1-9
DOI: 10.1016/j.neurobiolaging.2019.06.012
A 224Ra-labeled polyoxopalladate as putative radiopharmaceutical
Gott, M.; Yang, P.; Kortz, U.; Stephan, H.; Pietzsch, H.-J.; et al. (6 authors)
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Chemical Communications 55(2019), 7631-7634
DOI: 10.1039/C9CC02587A
Interobserver variability of image-derived arterial blood SUV in whole-body FDG PET
Hofheinz, F.; Maus, J.; Zschaeck, S.; Rogasch, J.; Schramm, G.; et al. (9 authors)
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EJNMMI Research 9(2019), 23
DOI: 10.1186/s13550-019-0486-9
Time efficient scatter correction for time-of-flight PET: the immediate scatter approximation
Nikulin, P.; Maus, J.; Hofheinz, F.; Lougovski, A.; van den Hoff, J.
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Physics in Medicine and Biology 64(2019), 075005
DOI: 10.1088/1361-6560/ab0e9b
SPECT-Untersuchungen mit dem 123 I-markierten Dopamintransporter-Liganden FP-CIT (DaTSCAN):DGN-Handlungsempfehlung (S1-Leitlinie)
Tatsch, K.; Buchert, R.; Bartenstein, P.; Barthel, H.; Boecker, H.; et al. (17 authors)
- Nuklearmedizin 58(2019)1, 5-16
In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine – a Radioligand for Imaging σ1 Receptors with Positron Emission Tomography (PET)
Ludwig, F.-A.; Fischer, S.; Houska, R.; Hoepping, A.; Deuther-Conrad, W.; et al. (15 authors)
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Frontiers in Pharmacology 10(2019), 534
DOI: 10.3389/fphar.2019.00534
Limited importance of EphrinA1–ligand, Src kinase, and focal adhesion kinase in EphA2-mediated regulation of metastasis in Mel-Juso and A375 human melanoma cells
Neuber, C.; Herwig, N.; Pietzsch, J.; Belter, B.
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Journal of Cellular Biotechnology 5(2019)1, 11-26
DOI: 10.3233/JCB-189010
ISSN: 2352-3689
Regulation of A375 melanoma cell adhesion and migration by EphB4 and EphrinB2 –insights from co-culture experiments
Neuber, C.; Laube, M.; Mamat, C.; Belter, B.; Pietzsch, J.
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Journal of Cellular Biotechnology 5(2019)1, 27-42
DOI: 10.3233/JCB-189011
ISSN: 2352-3689
Radiochemical and radiopharmacological characterization of a 64Cu-labeled α-MSH analog conjugated with different chelators
Gao, F.; Sihver, W.; Bergmann, R.; Walther, M.; Stephan, H.; et al. (11 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 495-509
DOI: 10.1002/jlcr.3728
Fluorescent Mouse Pheochromocytoma Spheroids Expressing Hypoxia-Inducible Factor 2 alpha: Morphologic and Radiopharmacologic Characterization
Seifert, V.; Liers, J.; Kniess, T.; Richter, S.; Bechmann, N.; et al. (10 authors)
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Journal of Cellular Biotechnology 5(2019)2, 135-151
DOI: 10.3233/JCB-199005
ISSN: 2352-3689
Facile preparation of radium-doped, functionalized nanoparticles as carriers for targeted alpha therapy
Reissig, F.; Hübner, R.; Steinbach, J.; Pietzsch, H.-J.; Mamat, C.
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Inorganic Chemistry Frontiers 6(2019), 1341-1349
DOI: 10.1039/c9qi00208a
Carboranyl Analogues of Celecoxib with Potent Cytostatic Activity against Human Melanoma and Colon Cancer Cell Lines
Buzharevski, A.; Paskas, S.; Sárosi, M. B.; Laube, M.; Lönnecke, P.; et al. (10 authors)
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ChemMedChem 14(2019)3, 315-321
DOI: 10.1002/cmdc.201800685
Fluorine-18 labeling of S100 proteins for small animal positron emission tomography
Laube, M.; Kniess, T.; Neuber, C.; Haase-Kohn, C.; Pietzsch, J.
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Methods in Molecular Biology 1929(2019), 461-485
DOI: 10.1007/978-1-4939-9030-6_29
ISSN: 1064-3745
Development and radiosynthesis of the first 18F-labeled inhibitor of monocarboxylate transporters (MCTs)
Sadeghzadeh, M.; Moldovan, R.-P.; Fischer, S.; Wenzel, B.; Ludwig, F.-A.; et al. (14 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 411-424
DOI: 10.1002/jlcr.3739
FDG-PET/MRI in patients with pelvic recurrence of rectal cancer: first clinical experiences
Plodeck, V.; Rahbari, N.; Weitz, J.; Radosa, C.; Laniado, M.; et al. (11 authors)
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European Radiology 29(2019), 422-428
DOI: 10.1007/s00330-018-5589-6
Synthesis, Structural Characterization and Photodecarbonylation Study of a Dicarbonyl Ruthenium(II)-Bisquinoline Complex
Kubeil, M.; Joshi, T.; Wood, B. R.; Stephan, H.
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ChemistryOpen 8(2019), 637-642
DOI: 10.1002/open.201900111
Synthesis and preliminary radiopharmacological characterisation of an 11C-labelled azadipeptide nitrile as potential PET tracer for imaging of cysteine cathepsins
Laube, M.; Frizler, M.; Wodtke, R.; Neuber, C.; Belter, B.; et al. (10 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 448-459
DOI: 10.1002/jlcr.3729
Tarnkappen-Technologie für leuchtende Nanopartikeln
Stephan, H.; Zarschler, K.
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GIT Labor-Fachzeitschrift (2019)8, 55-57
Tonic signaling and its effects on lymphopoiesis of CAR-armed hematopoietic stem and progenitor cells
Albert, S.; Koristka, S.; Gerbaulet, A.; Cartellieri, M.; Arndt, C.; et al. (15 authors)
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Journal of Immunology 202(2019)6, 1735-1746
DOI: 10.4049/jimmunol.1801004
Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study
Mutsaerts, H. J. M. M.; Mirza, S. S.; Petr, J.; Thomas, D. L.; Cash, D. M.; et al. (31 authors)
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Brain 142(2019), 1108-1120
DOI: 10.1093/brain/awz039
Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18
Wenzel, B.; Liu, J.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Teodoro, R.; et al. (10 authors)
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Bioorganic Chemistry 86(2019), 346-362
DOI: 10.1016/j.bioorg.2019.01.037
Synthesis, 18F-labelling and radiopharmacological characterisation of the C-terminal 30mer of Clostridium perfringens enterotoxin as a potential claudin-targeting peptide
Löser, R.; Bader, M.; Kuchar, M.; Wodtke, R.; Lenk, J.; et al. (12 authors)
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Amino Acids 51(2019)2, 219-244
Online First (2018) DOI: 10.1007/s00726-018-2657-9
Neoadjuvant radiochemotherapy significantly alters the phenotype of plasmacytoid dendritic cells and 6-sulfo LacNAc+ monocytes in rectal cancer
Wagner, F.; Hölig, U.; Wilczkowski, F.; Sommer, U.; Wehner, R.; et al. (23 authors)
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Frontiers in Immunology 10(2019), 602
DOI: 10.3389/fimmu.2019.00602
Cathepsin B: Active Site Mapping with Peptidic Substrates and Inhibitors
Schmitz, J.; Gilberg, E.; Löser, R.; Bajorath, J.; Bartz, U.; et al. (6 authors)
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Bioorganic & Medicinal Chemistry 27(2019)1, 1-15
Online First (2018) DOI: 10.1016/j.bmc.2018.10.017
One-pot Cascade Synthesis of Pyrazole-based Isosteres of Valdecoxib by a [3+2] Cycloaddition/[1,5] Sigmatropic Rearrangement Sequence and Evaluation of their COX Inhibitory Activity
Roscales, S.; Bechmann, N.; Pietzsch, J.; Kniess, T.
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Heterocycles 98(2019)3, 416-428
DOI: 10.3987/COM-19-14048
Anti-CAR engineered T cells for epitope-based elimination of autologous CAR T cells
Koristka, S.; Ziller-Walter, P.; Bergmann, R.; Arndt, C.; Feldmann, A.; et al. (11 authors)
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Cancer Immunology, Immunotherapy (2019), 1401-1415
DOI: 10.1007/s00262-019-02376-y
Access to 18F-labelled isoxazoles by Ruthenium-promoted 1,3-dipolar cycloaddition of 4-[18F]fluoro-N-hydroxybenzimidoyl chloride with alkynes.
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019), 393-403
DOI: 10.1002/jlcr.3708
Expression of Glypican-3 is an Independent Prognostic Biomarker in Primary Gastro-Esophageal Adenocarcinoma and Corresponding Serum Exosomes
Rahbari, M.; Pecqueux, M.; Aust, D.; Stephan, H.; Tiebel, O.; et al. (14 authors)
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Journal of Clinical Medicine 8(2019), 696
DOI: 10.3390/jcm8050696
Prognostic value of SUR in patients with trimodality treatment of locally advanced esophageal carcinoma
Bütof, R.; Hofheinz, F.; Zöphel, K.; Schmollack, J.; Jentsch, C.; et al. (9 authors)
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Journal of Nuclear Medicine 60(2019)2, 192-198
Online First (2018) DOI: 10.2967/jnumed.117.207670
Studies towards the development of a PET radiotracer for imaging of the P2Y1 receptors in the brain: synthesis, 18F-labeling and preliminary biological evaluation
Moldovan, R.-P.; Wenzel, B.; Teodoro, R.; Neumann, W.; Dukic-Stefanovic, S.; et al. (9 authors)
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European Journal of Medicinal Chemistry (2019), 142-159
DOI: 10.1016/j.ejmech.2019.01.006
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